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Akademický článek
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Publikováno v:
Journal of Biological Chemistry. 268:12552-12559
A major mechanism of regulation of mammalian protein synthesis initiation is accomplished by the phosphorylation of the alpha subunit of eukaryotic initiation factor (eIF) 2. This modification inhibits the activity of another initiation factor, guani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a2710bb133f7876b8959f21e10a7cf3
https://doi.org/10.1016/s0021-9258(18)31424-8
https://doi.org/10.1016/s0021-9258(18)31424-8
Publikováno v:
European journal of biochemistry. 195(2)
Several recent publications indicate that Ca2+ is required for protein synthesis in mammalian cells, including the Ehrlich ascites tumor cell. The present communication examines whether the effects of Ca2+ might be mediated through calmodulin or a re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4552d1d93772f5d29210b20aff9c6d2f
https://pubmed.ncbi.nlm.nih.gov/1997317
https://pubmed.ncbi.nlm.nih.gov/1997317
Autor:
Edgar C. Henshaw, Kathleen S. Montine
Publikováno v:
Biochemical and biophysical research communications. 166(3)
Increased phosphorylation of ribosomal protein S6 has been extensively correlated with an increased rate of protein synthesis. We report here that under two separate conditions in Ehrlich cells an increase in the level of S6 phosphorylation does not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aecc3ac5d8033f7529827e1bbda7a543
https://pubmed.ncbi.nlm.nih.gov/2306245
https://pubmed.ncbi.nlm.nih.gov/2306245
Publikováno v:
Journal of Biological Chemistry. 255:1486-1491
The ratio of initiation of protein synthesis in Ehrlich ascites tumor cells in culture is reduced by over 60% in the absence of a single essential amino acid. Cell-free extracts prepared from control and amino acid-starved cells retain some of the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1199867ac01efd9fcb28b5291fb2b032
https://doi.org/10.1016/s0021-9258(19)86057-x
https://doi.org/10.1016/s0021-9258(19)86057-x
Mechanism of inhibition of polypeptide chain initiation in heat-shocked Ehrlich ascites tumour cells
Autor:
R Panniers, Edgar C. Henshaw
Publikováno v:
European Journal of Biochemistry. 140:209-214
The rate of polypeptide synthesis is inhibited by 80% in Ehrlich cells incubated at 43 degrees C compared to those at 37 degrees C. The regulatory site of translation resides at polypeptide chain initiation. Polypeptide synthesis does not recover at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5db42d3a86e4a471b27a60b3345003
https://doi.org/10.1111/j.1432-1033.1984.tb08088.x
https://doi.org/10.1111/j.1432-1033.1984.tb08088.x
Publikováno v:
Journal of Biological Chemistry. 263:5519-5525
A major site of regulation of polypeptide chain initiation is the binding of Met-tRNA to 40 S ribosomal subunits which is mediated by eukaryotic initiation factor 2 (eIF-2). The formation of ternary complex, eIF-2.GTP.Met-tRNA, is potently inhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e77a6dad2f62e96596d8e14d72c4107d
https://doi.org/10.1016/s0021-9258(18)60595-2
https://doi.org/10.1016/s0021-9258(18)60595-2
Publikováno v:
Cancer. 43:1619-1623
Autologous, irradiated (10,000 rads) tumor cells mixed with C. parvum were given as weekly intracutaneous injections to fifteen patients with residual malignant disease. The toxicity was minimal and distinctly less than has been seen with tumor cell-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f59cbefbff44c52b9c1a5c76817b9f6
https://doi.org/10.1002/1097-0142(197905)43:5<1619::aid-cncr2820430509>3.0.co
https://doi.org/10.1002/1097-0142(197905)43:5<1619::aid-cncr2820430509>3.0.co
Autor:
Edgar C. Henshaw, Walter Mastropaolo
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. 656:246-255
The incorporation of 32Pi into the ribosomal protein S6, which is a component of the 40 S ribosomal subunit, was measured in Ehrlich ascites tumor cells growing in suspension culture. During a 2-h incubation period, incorporation was 10-fold greater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02922533df12f5efd93e3b6bf0e54382
https://doi.org/10.1016/0005-2787(81)90093-9
https://doi.org/10.1016/0005-2787(81)90093-9