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Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity

Autor: Srinivas R, Kasibhatla, Kevin, Hong, Marco A, Biamonte, David J, Busch, Patricia L, Karjian, John L, Sensintaffar, Adeela, Kamal, Rachel E, Lough, John, Brekken, Karen, Lundgren, Roy, Grecko, Gregg A, Timony, Yingqing, Ran, Robert, Mansfield, Lawrence C, Fritz, Edgar, Ulm, Francis J, Burrows, Marcus F, Boehm

Publikováno v: Journal of medicinal chemistry. 50(12)

Heat shock protein 90 (Hsp90) is a molecular chaperone protein implicated in stabilizing the conformation and maintaining the function of many cell-signaling proteins. Many oncogenic proteins are more dependent on Hsp90 in maintaining their conformat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d4b2feee8ee425cef56bd83ad21acf6
https://pubmed.ncbi.nlm.nih.gov/17488003

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