Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Edgar, Pan"'
Autor:
Evgenii Skurikhin, Mariia Zhukova, Natalia Ermakova, Edgar Pan, Darius Widera, Lubov Sandrikina, Lena Kogai, Nikolai Kushlinskii, Aslan Kubatiev, Sergey Morozov, Alexander Dygai
Publikováno v:
Thoracic Cancer, Vol 15, Iss 28, Pp 2000-2020 (2024)
Abstract Background Awareness of age‐related features of carcinogenesis and the importance of cellular immunity is crucial for developing effective antitumor therapies for specific patient groups. Methods In this study, we examined different popula
Externí odkaz:
https://doaj.org/article/14ea565086e046ae81cd8795708ec1a8
Autor:
Angelina Pakhomova, Olga Pershina, Pavel Bochkov, Natalia Ermakova, Edgar Pan, Lubov Sandrikina, Yulia Dagil, Lena Kogai, Wolf-Dieter Grimm, Mariia Zhukova, Sergey Avdeev
Publikováno v:
Life, Vol 13, Iss 9, p 1932 (2023)
Idiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung disease, characterized by progressive parenchymal fibrosis and respiratory failure. In a model of bleomycin-induced pulmonary fibrosis, the antifibrotic and anti
Externí odkaz:
https://doaj.org/article/859f369d93d44876bfa9a90518d7e560
Autor:
Evgenii G. Skurikhin, Olga Pershina, Mariia Zhukova, Angelina Pakhomova, Natalia Ermakova, Darius Widera, Edgar Pan, Lubov Sandrikina, Lena Kogai, Nikolai Kushlinskii, Sergey Morozov, Aslan Kubatiev, Alexander Dygai
Publikováno v:
Medical Sciences Forum, Vol 21, Iss 1, p 40 (2023)
We have developed an approach to reprogramming immune cells by inhibiting the MAPK/ERK pathway through MEKi and the PD-1/PD-L1 immune checkpoint signaling pathway. We hypothesized that reprogramming of spleen CD8+ T-cells could also create a populati
Externí odkaz:
https://doaj.org/article/bb9ba8d48c7a45bb97bd5b376549c677
Autor:
Evgenii Skurikhin, Olga Pershina, Mariia Zhukova, Darius Widera, Natalia Ermakova, Edgar Pan, Angelina Pakhomova, Sergey Morozov, Aslan Kubatiev, Alexander Dygai
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Despite the increasing urgency of the problem of treating small cell lung cancer (SCLC), information on the causes of its development is fragmentary. There is no complete understanding of the features of antitumor immunity and the role of the microen
Externí odkaz:
https://doaj.org/article/382cba3cb52546d5881997b33fd66992
Autor:
Evgenii G. Skurikhin, Olga Pershina, Natalia Ermakova, Angelina Pakhomova, Mariia Zhukova, Edgar Pan, Lubov Sandrikina, Darius Widera, Lena Kogai, Nikolai Kushlinskii, Aslan Kubatiev, Sergey G. Morozov, Alexander Dygai
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15780 (2022)
Using a model of Lewis lung carcinoma (LLC) in vitro and in vivo, we previously demonstrated increased antitumor activity in CD8+ T-cells reprogrammed with an MEK inhibitor and PD-1 blocker. In this follow-up study, we carried out the reprogramming o
Externí odkaz:
https://doaj.org/article/df276f7f78f145a089c0f8233fdfcc6f
Autor:
Evgenii G. Skurikhin, Natalia Ermakova, Mariia Zhukova, Olga Pershina, Edgar Pan, Angelina Pakhomova, Lena Kogai, Victor Goldberg, Elena Simolina, Victoria Skurikhina, Darius Widera, Aslan Kubatiev, Sergey G. Morozov, Nikolai Kushlinskii, Alexander Dygai
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10853 (2022)
Current methods for diagnosis and treatment of small cell lung cancer (SCLC) have only a modest efficacy. In this pilot study, we analyzed circulating tumor cells (CTCs) and cancer stem cells (CSCs) in patients with SCLC to search for new diagnostic
Externí odkaz:
https://doaj.org/article/ae3a008b226e45858f25943586754ba8
Autor:
Evgenii G. Skurikhin, Olga Pershina, Natalia Ermakova, Angelina Pakhomova, Darius Widera, Mariia Zhukova, Edgar Pan, Lubov Sandrikina, Lena Kogai, Nikolai Kushlinskii, Sergey G. Morozov, Aslan Kubatiev, Alexander Dygai
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1450 (2022)
CD8+ T-lymphocytes play a key role in antitumor immune response. Patients with lung cancer often suffer from T-lymphocyte dysfunction and low T-cell counts. The exhaustion of effector T-lymphocytes largely limits the effectiveness of therapy. In this
Externí odkaz:
https://doaj.org/article/1793dad86e2f4025a71011239a194a65
Autor:
Angelina Pakhomova, Olga Pershina, Vladimir Nebolsin, Natalia Ermakova, Vyacheslav Krupin, Lubov Sandrikina, Edgar Pan, Darius Widera, Alexander Dygai, Evgenii Skurikhin
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Metabolic syndrome can lead to several challenging complications including degeneration of the pancreas and hypogonadism. Recently, we have shown that Bisamide Derivative of Dicarboxylic Acid (BDDA) can contribute to pancreatic restoration in mice wi
Externí odkaz:
https://doaj.org/article/5bfc806b02074fd794b9ad942bd65b14
Autor:
Olga Pershina, Natalia Ermakova, Angelina Pakhomova, Darius Widera, Edgar Pan, Mariia Zhukova, Elena Slonimskaya, Sergey G. Morozov, Aslan Kubatiev, Alexander Dygai, Evgenii G. Skurikhin
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1223 (2021)
New drug targets, markers of disease prognosis, and more efficient treatment options are an unmet clinical need in breast cancer (BC). We have conducted a pilot study including patients with luminal B stage breast cancer IIA–IIIB. The presence and
Externí odkaz:
https://doaj.org/article/edebd5e7ec9f4232a9ab81044b26cce3
Autor:
Evgenii Skurikhin, Pavel Madonov, Olga Pershina, Natalia Ermakova, Angelina Pakhomova, Darius Widera, Edgar Pan, Mariia Zhukova, Lubov Sandrikina, Andrey Artamonov, Alexander Dygai
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5599 (2021)
Concentration of hyaluronic acid (HA) in the lungs increases in idiopathic pulmonary fibrosis (IPF). HA is involved in the organization of fibrin, fibronectin, and collagen. HA has been proposed to be a biomarker of fibrosis and a potential target fo
Externí odkaz:
https://doaj.org/article/93aa8429a5dc4d33ade28753709e6bae