Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Edgar, Buhl"'
Autor:
Amina Aboufares El Alaoui, Edgar Buhl, Sabrina Galizia, James J. L. Hodge, Luisa de Vivo, Michele Bellesi
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Prolonged cellular activity may overload cell function, leading to high rates of protein synthesis and accumulation of misfolded or unassembled proteins, which cause endoplasmic reticulum (ER) stress and activate the unfolded prot
Externí odkaz:
https://doaj.org/article/3e57547dfbcf4ac993fb19b4ab38e84b
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/e06ea4821b0049a8b2ec70887da07b40
Autor:
Edgar Buhl, Yoon A. Kim, Tom Parsons, Bangfu Zhu, Ismael Santa-Maria, Roger Lefort, James J.L. Hodge
Publikováno v:
Neurobiology of Disease, Vol 170, Iss , Pp 105752- (2022)
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease placing a great burden on people living with it, carers and society. Yet, the underlying patho-mechanisms remain unknown and treatments limited. To better understand the molecul
Externí odkaz:
https://doaj.org/article/fd2be2bb18ac40dd95bf0d2f58dcc521
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Insects are ectothermal animals that are constrained in their survival and reproduction by external temperature fluctuations which require either active avoidance of or movement towards a given heat source. In Drosophila, different thermorec
Externí odkaz:
https://doaj.org/article/0aaea794aeb948d5b26e08e59be028b0
Publikováno v:
Neurobiology of Disease, Vol 104, Iss , Pp 15-23 (2017)
Parkinson's disease (PD) is more commonly associated with its motor symptoms and the related degeneration of dopamine (DA) neurons. However, it is becoming increasingly clear that PD patients also display a wide range of non-motor symptoms, including
Externí odkaz:
https://doaj.org/article/a67a2826f0bd4fe8ba1b9b84a88b7e6a
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 6, Pp 705-716 (2017)
Mutations in the proline dehydrogenase gene PRODH are linked to behavioral alterations in schizophrenia and as part of DiGeorge and velo-cardio-facial syndromes, but the role of PRODH in their etiology remains unclear. Here, we establish a Drosophila
Externí odkaz:
https://doaj.org/article/9a9fe22a3a9245269c637c9cc24628c2
Autor:
Silvia Beatriz Sanchez Marco, Edgar Buhl, Rose Firth, Bangfu Zhu, Mary Gainsborough, Ana Beleza‐Meireles, Sandra Moore, Richard Caswell, Karen Stals, Sian Ellard, Cameron Kennedy, James J. L. Hodge, Anirban Majumdar
Publikováno v:
Clinical Genetics. 102:494-502
Cerebral palsy (CP) causes neurological disability in early childhood. Hypoxic-ischaemic injury plays a major role in its aetiology, nevertheless, genetic and epigenetic factors may contribute to the clinical presentation. Mutations in ADD3 (encoding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e09c9abdbf9b1a05ea294eec0fbec4c
https://doi.org/10.1111/cge.14220
https://doi.org/10.1111/cge.14220
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104507- (2019)
Alzheimer's disease (AD) is the most common cause of dementia, which is associated with an enormous personal, social and economic burden worldwide. However, there are few current treatments with none of them targeting the underlying causes of the dis
Externí odkaz:
https://doaj.org/article/bbef4632ff8349deb5133327343599e6
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The cellular underpinnings of memory deficits in Alzheimer’s disease (AD) are poorly understood. We utilized the tractable neural circuits sub-serving memory in Drosophila to investigate the role of impaired Ca2+ handling in memory deficits caused
Externí odkaz:
https://doaj.org/article/66db0f95a6344ca9b7754c3e27d9ee18
Autor:
James P. Higham, Bilal R. Malik, Edgar Buhl, Jennifer M. Dawson, Anna S. Ogier, Katie Lunnon, James J. L. Hodge
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Alzheimer’s disease (AD) is the most common form of dementia and is characterized by intracellular neurofibrillary tangles of hyperphosphorylated Tau, including the 0N4R isoform and accumulation of extracellular amyloid beta (Aβ) plaques. However,
Externí odkaz:
https://doaj.org/article/dfb00dbe3c7f4fae983b05d1a792dda8