Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Eden R, Freire"'
Autor:
Maria J. R. Bezerra, Danielle M. N. Moura, Eden R. Freire, Fabiola B. Holetz, Christian R. S. Reis, Tallyta T. S. Monteiro, Adriana R. S. Pinto, Ning Zhang, Antonio M. Rezende, Antonio Pereira-Neves, Regina C. B. Q. Figueiredo, Christine Clayton, Mark C. Field, Mark Carrington, Osvaldo P. de Melo Neto
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Gene expression in pathogenic protozoans of the family Trypanosomatidae has several novel features, including multiple eIF4F-like complexes involved in protein synthesis. The eukaryotic eIF4F complex, formed mainly by eIF4E and eIF4G subunits, is res
Externí odkaz:
https://doaj.org/article/209fd9a580714eabae65717513a48ea1
Publikováno v:
Pathogens, Vol 6, Iss 4, p 55 (2017)
Trypanosomatid protozoa are unusual eukaryotes that are well known for having unusual ways of controlling their gene expression. The lack of a refined mode of transcriptional control in these organisms is compensated by several post-transcriptional c
Externí odkaz:
https://doaj.org/article/2dce9afec9f64853b303daffcdb16450
The translation initiation factor EIF4E5 from Leishmania: crystal structure and interacting partners
Autor:
Adriana Neuman Albuquerque Lins Moura de Brito, Christian R. S. Reis, Tatiana Reichert da Silva Assunção, Nilson Ivo Tonin Zanchin, Osvaldo Pompílio de-Melo-Neto, Thaíse Yasmine Vasconcelos de Lima Cavalcanti, Eden R. Freire, Beatriz G. Guimarães, Rafaela Paiva Andrade-Vieira, Ludmilla Arruda de Assis, Gustavo Barbosa de Lima
Publikováno v:
RNA Biol
The mRNA cap-binding protein, eIF4E, mediates the recognition of the mRNA 5ʹ end and, as part of the heterotrimeric eIF4F complex, facilitates the recruitment of the ribosomal subunits to initiate eukaryotic translation. Various regulatory events in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5354ed344699976f42ae3025228a12bc
https://pubmed.ncbi.nlm.nih.gov/33945405
https://pubmed.ncbi.nlm.nih.gov/33945405
Autor:
Danielle M.N. Moura, Ajay A. Vashisht, Camila C. Xavier, Antonio Mauro Rezende, Eden R. Freire, James A. Wohlschlegel, Nancy R. Sturm, David A. Campbell, Osvaldo P. de Melo Neto, Mariana C. Morais-Sobral, Maria José Ribeiro Bezerra
Publikováno v:
Current genetics. 64(4)
Trypanosomatids are parasitic protozoans characterized by several unique structural and metabolic processes that include exquisite mechanisms associated with gene expression and regulation. During the initiation of protein synthesis, for instance, mR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de9bb0f7366a40b97d43f80659652f7
https://pubmed.ncbi.nlm.nih.gov/29288414
https://pubmed.ncbi.nlm.nih.gov/29288414
Autor:
Amaranta M. Malvezzi, Nancy R. Sturm, Osvaldo P. de Melo Neto, Joanna Zuberek, Edward Darzynkiewicz, Danielle M.N. Moura, Kent L. Hill, Edwin A. Saada, Gerasimos Langousis, James A. Wohlschlegel, Ajay A. Vashisht, David A. Campbell, Janaina de Freitas Nascimento, Eden R. Freire
Publikováno v:
Eukaryotic cell, vol 13, iss 7
Trypanosomes lack the transcriptional control characteristic of the majority of eukaryotes that is mediated by gene-specific promoters in a one-gene–one-promoter arrangement. Rather, their genomes are transcribed in large polycistrons with no obvio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f5af473488ee5c96d0a5095baaedfc
https://doi.org/10.1128/ec.00071-14
https://doi.org/10.1128/ec.00071-14
Autor:
Osvaldo P. de Melo Neto, Joanna Zuberek, Edward Darzynkiewicz, Gerasimos Langousis, James A. Wohlschlegel, Ajay A. Vashisht, Amaranta M. Malvezzi, Janusz Stepinski, Janaina de Freitas Nascimento, Kent L. Hill, Nancy R. Sturm, Eden R. Freire, David A. Campbell, Edwin A. Saada
Publikováno v:
RNA. 20:1272-1286
Members of the eIF4E mRNA cap-binding family are involved in translation and the modulation of transcript availability in other systems as part of a three-component complex including eIF4G and eIF4A. The kinetoplastids possess four described eIF4E an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae9a3110536919124e9c60e34ebe864
https://doi.org/10.1261/rna.045534.114
https://doi.org/10.1261/rna.045534.114
Autor:
Mark Carrington, Danielle M.N. Moura, Osvaldo P. de Melo Neto, Christian R. S. Reis, Eden R. Freire
Publikováno v:
Evolution of the Protein Synthesis Machinery and Its Regulation ISBN: 9783319394671
Trypanosomatids are flagellated protozoans that diverged very early on from the lineages leading to the other eukaryotic groups with the consequence that they have evolved separately for ~1 billion years. Pathogenic trypanosomatids, belonging mainly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0206c5e6dc16009068160a86bbdd7465
https://doi.org/10.1007/978-3-319-39468-8_17
https://doi.org/10.1007/978-3-319-39468-8_17
Autor:
Tamara D. da Costa Lima, Amaranta M. Malvezzi, Danielle M.N. Moura, Christian R. S. Reis, Mariana M.C. Pereira, Viviane S. Alves, Larissa M. Nascimento, Eden R. Freire, Mariana L. Palma, Osvaldo P. de Melo Neto
Publikováno v:
Molecular and biochemical parasitology. 190(2)
The eukaryotic eIF4F complex, the cap binding complex, functions during translation initiation through interactions mediated by its three subunits (eIF4E, eIF4G and eIF4A), other initiation factors and the ribosome. In trypanosomatids, various eIF4E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540aaa5c4b4f4874f8578d5fffb13376
https://pubmed.ncbi.nlm.nih.gov/23867205
https://pubmed.ncbi.nlm.nih.gov/23867205
Autor:
Nancy Standart, Christian R. S. Reis, Rodrigo P. Lima, Mark Carrington, Katie Hughes, Tamara D. da Costa Lima, Danielle M.N. Moura, Eden R. Freire, Rafael Dhalia, Osvaldo P. de Melo Neto, Regina Celia Bressan Queiroz de Figueiredo
Publikováno v:
Molecular and biochemical parasitology. 176(1)
Translation initiation in eukaryotes requires eIF4E, the cap binding protein, which mediates its function through an interaction with the scaffolding protein eIF4G, as part of the eIF4F complex. In trypanosomatids, four eIF4E homologues have been des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96dfef677ccc6c4eed76c463b74dca5
https://pubmed.ncbi.nlm.nih.gov/21111007
https://pubmed.ncbi.nlm.nih.gov/21111007
Autor:
João R. C. Muniz, Osvaldo P. de Melo Neto, Eden R. Freire, Rafael Dhalia, Pollyanna O. Rocha, Rodolfo Katz, Nancy Standart, Christian R. S. Reis
Publikováno v:
Molecular and biochemical parasitology. 140(1)
In eukaryotes protein synthesis initiates with the binding of the multimeric translation initiation complex eIF4F – eIF4E, eIF4A and eIF4G – to the monomethylated cap present on the 5′ end of mRNAs. eIF4E interacts directly with the cap nucleot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d0e9ee0e48f299c174a4c56aac89f2
https://pubmed.ncbi.nlm.nih.gov/15694484
https://pubmed.ncbi.nlm.nih.gov/15694484