Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Eden Padayachee"'
Autor:
Sibusiso Maseko, Eden Padayachee, Siyabonga Maphumulo, Thavendran Govender, Yasien Sayed, Glenn Maguire, Johnson Lin, Tricia Naicker, Sooraj Baijnath, Kruger Hendrik Gerhardus
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1451-1456 (2019)
Herein, we report the effect of nine FDA approved protease inhibitor drugs against a new HIV-1 subtype C mutant protease, E35D↑G↑S. The mutant has five mutations, E35D, two insertions, position 36 (G and S), and D60E. Kinetics, inhibition constan
Externí odkaz:
https://doaj.org/article/7cf85bb306e84bccb250ab8de1558f8a
Autor:
Neelakshi Mungra, Guillaume Vignaux, Jean Engohang-Ndong, Eden Padayachee, Jean De La Croix Ndong, Fleury Augustin Nsole Biteghe, Stefan Barth, Nyangone Ekome Toung Chalomie, Krupa Naran
Publikováno v:
Oncotarget
The epidermal growth factor receptor (EGFR) has been recognized as an important therapeutic target in oncology. It is commonly overexpressed in a variety of solid tumors and is critically involved in cell survival, proliferation, metastasis, and angi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf8533024610c1687cd04d365fe705b
https://doi.org/10.18632/oncotarget.27730
https://doi.org/10.18632/oncotarget.27730
Autor:
Glenn E. M. Maguire, Eden Padayachee, Gert Kruger, Sibusiso B. Maseko, Thavendran Govender, Yasien Sayed, Johnson Lin
Publikováno v:
Biological Chemistry. 398:1109-1117
The efficacy of HIV-1 protease (PR) inhibition therapies is often compromised by the emergence of mutations in the PR molecule that reduces the binding affinity of inhibitors while maintaining viable catalytic activity and affinity for natural substr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d682d69a0e0bb939c3ffbdd6366fcab7
https://doi.org/10.1515/hsz-2017-0107
https://doi.org/10.1515/hsz-2017-0107
Autor:
Stefan Barth, Dirk Bauerschlag, Fleury Augustin Nsole Biteghe, Eden Padayachee, Zaria Malindi
Publikováno v:
Transfusion Medicine and Hemotherapy. 44:303-310
Considerable research efforts have been dedicated to understanding ovarian and breast cancer mechanisms, but there has been little progress translating the research into effective clinical applications. Hence, personalized/precision medicine has emer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7f432b321353925d3fd5a93cf89d4c
https://doi.org/10.1159/000479979
https://doi.org/10.1159/000479979
Autor:
Eden Padayachee, Lester M. Davids, Fleury Augustin Nsole Biteghe, Jean De La Croix Ndong, Nyangone Ekome Toung Chalomie, Stefan Barth
Publikováno v:
Journal of photochemistry and photobiology. B, Biology. 211
Aberrant anti-cancer drug efflux mediated by membrane protein ABC transporters (ABCB5 and ABCG2) is thought to characterize melanoma heterogeneous chemoresistant populations, presumed to have unlimited proliferative and self-renewal abilities. Theref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2156579c56ac0dcef72cbcf3f5c4660
https://pubmed.ncbi.nlm.nih.gov/32866820
https://pubmed.ncbi.nlm.nih.gov/32866820
Autor:
Stefan Barth, Henry A. Adeola, Eden Padayachee, Nonhlanhla P. Khumalo, Shivan Chetty, Jennifer C. Van Wyk, Fleury Augustine Nsole Biteghe
Publikováno v:
Health Science Reports
Background Cancer treatment in the 21st century has seen immense advances in optical imaging and immunotherapy. Significant progress has been made in the bioengineering and production of immunoconjugates to achieve the goal of specifically targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa3398664a5587a381d93e0f76ac3f1
https://pubmed.ncbi.nlm.nih.gov/30809593
https://pubmed.ncbi.nlm.nih.gov/30809593
Publikováno v:
Neurochemical Research. 39:194-201
The incubation of neuronal nitric oxide synthase with the five amyloid peptide fragments [Aβ17-21; Aβ25-29; Aβ29-33; Aβ33-37; Aβ25-37] catalyzed the formation of fibrils. The role of neuronal isomer (nNOS) involved the entrapment of free monomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1060be86366ad061ba12fd54ea8556
https://doi.org/10.1007/s11064-013-1206-x
https://doi.org/10.1007/s11064-013-1206-x
Autor:
Eden Padayachee, C.G. Whiteley
Publikováno v:
Neuropeptides. 47:321-327
Aggregated β-amyloid deposit is a hallmark in the neuropathology of Alzheimer's disease but their mechanism of formation still remains unresolved. Previously we reported that a normal pentapeptide Aβ 17-21 and glycine zipper peptide Aβ 29-33 stron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17748a6b8fdfef3beb6b69d39581823
https://doi.org/10.1016/j.npep.2013.08.001
https://doi.org/10.1016/j.npep.2013.08.001
Autor:
C.G. Whiteley, Eden Padayachee
Publikováno v:
Neuropeptides. 47:171-178
Five peptide fragments [Aβ(17-21); Aβ(25-29); Aβ(29-33); Aβ(33-37); Aβ(25-37)] of the toxic Aβ(1-40(42)) amyloid peptide were shown to bind with neuronal nitric oxide synthase by means of hydrophobic-hydrophobic forces. The enzyme has a single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80da4570641be7431d49fc7a91f71c79
https://doi.org/10.1016/j.npep.2012.12.006
https://doi.org/10.1016/j.npep.2012.12.006
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 27:356-364
Neuronal nitric oxide synthase (nNOS) was purified on DEAE-Sepharose anion-exchange in a 38% yield, with 3-fold recovery and specific activity of 5 µmol.min(-1).mg(-1). The enzyme was a heterogeneous dimer of molecular mass 225 kDa having a temperat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c44283df8efcab8b91dad57604cf85
https://doi.org/10.3109/14756366.2011.590805
https://doi.org/10.3109/14756366.2011.590805