Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo.

Autor: Kashif Ahmed, Hesam Dehghani, Peter Rugg-Gunn, Eden Fussner, Janet Rossant, David P Bazett-Jones

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10531 (2010)

An open chromatin architecture devoid of compact chromatin is thought to be associated with pluripotency in embryonic stem cells. Establishing this distinct epigenetic state may also be required for somatic cell reprogramming. However, there has been

Externí odkaz: https://doaj.org/article/befe3a322598473db51305237b3dfebd

The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells

Autor: Nicholas P. Mullin, James Ellis, Ryuichi Nishinakamura, Eden Fussner, Ugljesa Djuric, Jasvinder Hayre, Calvin Tang, Clara Lopes Novo, Sarah Elderkin, Peter J. Rugg-Gunn, Ian Chambers, David P. Bazett-Jones, Kashif Ahmed, Arnold R. Sienerth, Natasha P. Morgan

Publikováno v: Lopes Novo, C, Tang, C, Ahmed, K, Djuric, U, Fussner, E, Mullin, N, Morgan, N, Hayre, J, Sienerth, A, Elderkin, S, Nishinakamura, R, Chambers, I, Ellis, J, Bazett-Jones, D P & Rugg-Gunn, P J 2016, ' The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells ', Genes & Development . https://doi.org/10.1101/gad.275685.115

An open and decondensed chromatin organization is a defining property of pluripotency. Several epigenetic regulators have been implicated in maintaining an open chromatin organization, but how these processes are connected to the pluripotency network

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb010720e0da516c395170a06f17304
https://doi.org/10.1101/gad.275685.115

Constitutive heterochromatin reorganization during somatic cell reprogramming

Autor: Eden Fussner, Fredrik Lanner, David P. Bazett-Jones, James Ellis, Mike Strauss, F. Jeffrey Dilworth, Carolina Perez-Iratxeta, Akitsu Hotta, Ugljesa Djuric

Publikováno v: The EMBO Journal. 30:1778-1789

Induced pluripotent stem (iPS) cell reprogramming is a gradual epigenetic process that reactivates the pluripotent transcriptional network by erasing and establishing repressive epigenetic marks. In contrast to loci-specific epigenetic changes, heter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d00fbc8fde6da665812bfbdcb38efef
https://doi.org/10.1038/emboj.2011.96

Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis

Autor: David M. Gilbert, Stephen Dalton, Kathrin Plath, Michael Kulik, Peter D. Rathjen, Tyrone Ryba, Eden Fussner, David P. Bazett-Jones, Mari Itoh, Bernadett Papp, Ichiro Hiratani, Joy Rathjen

Publikováno v: Genome Research. 20:155-169

Differentiation of mouse embryonic stem cells (mESCs) is accompanied by changes in replication timing. To explore the relationship between replication timing and cell fate transitions, we constructed genome-wide replication-timing profiles of 22 inde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e575546ac84656e7af897c4066760976
https://doi.org/10.1101/gr.099796.109

Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles

Autor: Timothy J, Nott, Evangelia, Petsalaki, Patrick, Farber, Dylan, Jervis, Eden, Fussner, Anne, Plochowietz, Timothy D, Craggs, David P, Bazett-Jones, Tony, Pawson, Julie D, Forman-Kay, Andrew J, Baldwin

Publikováno v: Molecular cell. 57(5)

Cells chemically isolate molecules in compartments to both facilitate and regulate their interactions. In addition to membrane-encapsulated compartments, cells can form proteinaceous and membraneless organelles, including nucleoli, Cajal and PML bodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc643cadecd53cca9338883055ced47e
https://pubmed.ncbi.nlm.nih.gov/33473198