Preclinical safety and efficacy of a therapeutic antibody that targets SARS-CoV-2 at the sotrovimab face but is escaped by Omicron.

Autor: Kreye J; German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.; Helmholtz Innovation Lab BaoBab (Brain Antibody-omics and B-cell Lab), 10117 Berlin, Germany.; Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; Department of Pediatric Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; Berlin Institute of Health at Charité, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Reincke SM; German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.; Helmholtz Innovation Lab BaoBab (Brain Antibody-omics and B-cell Lab), 10117 Berlin, Germany.; Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; Berlin Institute of Health at Charité, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Edelburg S; Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany., Jeworowski LM; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; German Centre for Infection Research (DZIF), 10117 Berlin, Germany., Kornau HC; German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.; Neuroscience Research Center (NWFZ), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Trimpert J; Institute of Virology, Freie Universität Berlin, 14163 Berlin, Germany., Hombach P; Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany., Halbe S; Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany., Nölle V; Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany., Meyer M; Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany., Kattenbach S; Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany., Sánchez-Sendin E; German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.; Helmholtz Innovation Lab BaoBab (Brain Antibody-omics and B-cell Lab), 10117 Berlin, Germany.; Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Schmidt ML; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; German Centre for Infection Research (DZIF), 10117 Berlin, Germany., Schwarz T; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; German Centre for Infection Research (DZIF), 10117 Berlin, Germany., Rose R; Institute for Infection Medicine, Christian-Albrechts-Universität zu Kiel and University Medical Center Schleswig-Holstein, 24105 Kiel, Germany., Krumbholz A; Institute for Infection Medicine, Christian-Albrechts-Universität zu Kiel and University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.; Labor Dr. Krause & Kollegen MVZ GmbH, 24106 Kiel, Germany., Merz S; IDEXX Laboratories, 70806 Kornwestheim, Germany., Adler JM; Institute of Virology, Freie Universität Berlin, 14163 Berlin, Germany., Eschke K; Institute of Virology, Freie Universität Berlin, 14163 Berlin, Germany., Abdelgawad A; Institute of Virology, Freie Universität Berlin, 14163 Berlin, Germany., Schmitz D; German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.; Neuroscience Research Center (NWFZ), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; Einstein Center for Neuroscience, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; NeuroCure Cluster of Excellence, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; Bernstein Center for Computational Neuroscience, Humboldt-Universität zu Berlin, 10115 Berlin, Germany., Sander LE; Department of Infectious Diseases and Respiratory Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Janssen U; Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany., Corman VM; Berlin Institute of Health at Charité, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; German Centre for Infection Research (DZIF), 10117 Berlin, Germany.; Labor Berlin-Charité Vivantes GmbH, Berlin, Germany., Prüss H; German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.; Helmholtz Innovation Lab BaoBab (Brain Antibody-omics and B-cell Lab), 10117 Berlin, Germany.; Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.

Publikováno v: IScience [iScience] 2023 Apr 21; Vol. 26 (4), pp. 106323. Date of Electronic Publication: 2023 Mar 02.