Chromatin Structure and Drug Resistance in Candida spp.

Autor: Callum J. O’Kane, Rachel Weild, Edel M. Hyland

Publikováno v: Journal of Fungi, Vol 6, Iss 3, p 121 (2020)

Anti-microbial resistance (AMR) is currently one of the most serious threats to global human health and, appropriately, research to tackle AMR garnishes significant investment and extensive attention from the scientific community. However, most of th

Externí odkaz: https://doaj.org/article/e65dd95faf654b708997072f68c07639

Characterization of the substrate binding site of an iron detoxifying membrane transporter from Plasmodium falciparum

Autor: Christopher J. Law, Edel M. Hyland, Veronika Tóth, Pragya Sharma

Publikováno v: Malaria Journal, Vol 20, Iss 1, Pp 1-14 (2021)
Malaria Journal
Sharma, P, Tóth, V, Hyland, E M & Law, C J 2021, ' Characterization of the substrate binding site of an iron detoxifying membrane transporter from Plasmodium falciparum ', Malaria Journal, vol. 20, 295 . https://doi.org/10.1186/s12936-021-03827-7

Background Plasmodium species are entirely dependent upon their host as a source of essential iron. Although it is an indispensable micronutrient, oxidation of excess ferrous iron to the ferric state in the cell cytoplasm can produce reactive oxygen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e5e0181ecb3b64d664ce64eb481b15
https://doaj.org/article/030af108791f4b79a84ceeed3c85cf4b

Gene Fusions derived by transcriptional readthrough are Driven by Segmental Duplication in Human

Autor: James O. McInerney, Ann M McCartney, Andrew E. Webb, Javier Prado-Martinez, Tomas Marques-Bonet, Julie L Aspden, Mary J. O'Connell, Christopher J. Creevey, Paul Cormican, Edel M. Hyland, Raymond J. Moran, Kate D. Lee, Jessica Hernandez-Rodriguez

Publikováno v: Am, M, Hyland, E M, Cormican, P, Moran, R J, Webb, A E, Lee, K D, Hernandez, J, Prado-Martinez, J, Creevey, C J, Aspden, J L, McInerney, J O, Marques-Bonet, T & Mj, OC 2019, ' Gene Fusions derived by transcriptional readthrough are Driven by Segmental Duplication in Human ', Genome biology and evolution, vol. 11, no. 9, pp. 2678–2690 . https://doi.org/10.1093/gbe/evz163
Genome Biology and Evolution
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Genome biology and evolution
Digital.CSIC. Repositorio Institucional del CSIC
instname
Recercat. Dipósit de la Recerca de Catalunya

Gene fusion occurs when two or more individual genes with independent open reading frames becoming juxtaposed under the same open reading frame creating a new fused gene. A small number of gene fusions described in detail have been associated with no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e3836d4aafbffa9c87bc8113300e22
https://pure.qub.ac.uk/en/publications/gene-fusions-derived-by-transcriptional-readthrough-are-driven-by-segmental-duplication-in-human(e57c44a1-faea-480e-85a0-012d5a78df6b).html

Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins

Autor: Sandya Subramanian, Erika Shor, Timothy Hoggard, Michael Weinreich, Edel M. Hyland, Fu-Jung Chang, Jessica Kenworthy, Catherine A. Fox, Jef D. Boeke, Julie Chueng, Kelsey Rae Perry

Publikováno v: PLoS Genetics, Vol 14, Iss 5, p e1007418 (2018)
Hoggard, T A, Chang, F, Perry, K R, Subramanian, S, Kenworthy, J, Chueng, J, Shor, E, Hyland, E M, Boeke, J D, Weinreich, M & Fox, C A 2018, ' Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins ', PLoS Genetics, vol. 14, no. 5, pp. e1007418 . https://doi.org/10.1371/journal.pgen.1007418
PLoS Genetics

Most active DNA replication origins are found within euchromatin, while origins within heterochromatin are often inactive or inhibited. In yeast, origin activity within heterochromatin is negatively controlled by the histone H4K16 deacetylase, Sir2,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f3a624f5325cda21023ddcc285f771
http://europepmc.org/articles/PMC5991416?pdf=render

Probing Nucleosome Function: A Highly Versatile Library of Synthetic Histone H3 and H4 Mutants

Autor: Daniel S. Yuan, Jef D. Boeke, Edel M. Hyland, Joel S. Bader, Hailiang Huang, Junbiao Dai

Publikováno v: Cell. 134(6):1066-1078

SummaryNucleosome structural integrity underlies the regulation of DNA metabolism and transcription. Using a synthetic approach, a versatile library of 486 systematic histone H3 and H4 substitution and deletion mutants that probes the contribution of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab6b4173938e7d1e6ccdc3385ff9c10