A systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1β, [corrected] TNF-α and IL-6 challenges in C57BL/6 mice.

Autor: Donal T Skelly, Edel Hennessy, Marc-Andre Dansereau, Colm Cunningham

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e69123 (2013)

It is increasingly clear that systemic inflammation has both adaptive and deleterious effects on the brain. However, detailed comparisons of brain effects of systemic challenges with different pro-inflammatory cytokines are lacking. In the present st

Externí odkaz: https://doaj.org/article/dad04e6ec61c45f6a5d8bfea0c46ccfa

OptiCogs: Feasibility of a multicomponent intervention to rehabilitate people with cognitive impairment post-stroke

Autor: Mairead O Donoghue, Pauline Boland, Sinead Taylor, Edel Hennessy, Eva Murphy, Siobhan Leahy, John McManus, Dominika Lisiecka, Helen Purtill, Rose Galvin, Sara Hayes

Background: Stroke is a leading cause of death and disability worldwide. Despite the prevalence and associated burden of cognitive impairment post-stroke, there is uncertainty regarding optimal cognitive rehabilitation for people post-stroke. This st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2393dbd109ab0279eb094135247f2aa6
https://doi.org/10.21203/rs.3.rs-2004048/v1

Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression

Autor: Éadaoin W. Griffin, Colm Cunningham, Carol L. Murray, Robert H. Field, Renata Rodrigues dos Reis, Orla Haugh, Ana Belen Lopez-Rodriguez, Lucas Silva Tortorelli, Lei Jin, Donal J. Cox, Ed C. Lavelle, Aisling Dunne, Arshed Nazmi, Edel Hennessy

Publikováno v: Glia

Type I interferons (IFN‐I) are the principal antiviral molecules of the innate immune system and can be made by most cell types, including central nervous system cells. IFN‐I has been implicated in neuroinflammation during neurodegeneration, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9bdd02f3f03fc551d9c5b74b654bd4
https://doi.org/10.1002/glia.23592

Cholinergic signalling in the forebrain controls microglial phenotype and responses to systemic inflammation

Autor: Éadaoin W. Griffin, Michelle M. Doran, John P. Lowry, Anthony W. McCarthy, Sean Doyle, Edel Hennessy, Robert H. Field, Martin O'Donnell, Arshed Nazmi, Daire Healy, Colm Cunningham, Aisling Rehill

(250)Loss of basal forebrain cholinergic projections occurs in Alzheimer’s disease, frontotemporal dementia and in aging. Moreover, nicotinic stimulation is anti-inflammatory in macrophages and microglia but how loss of basal forebrain acetylcholin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4afd1ecfcb1c61b18134e7ab95268a4e
https://doi.org/10.1101/2021.01.18.427123

Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration

Autor: Edel Hennessy, Carol L. Murray, S. Gormley, Ana Belen Lopez-Rodriguez, C. Murray, Colm Cunningham

Publikováno v: Hennessy, E, Gormley, S, Lopez-Rodriguez, A B, Murray, C, Murray, C & Cunningham, C 2017, ' Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration ', Brain, Behavior, and Immunity, vol. 59, pp. 233-244 . https://doi.org/10.1016/j.bbi.2016.09.011
Brain, Behavior, and Immunity

Graphical abstract
Highlights Mice with prior hippocampal neurodegeneration are more susceptible to systemic TNF-α, displaying: • Acute working memory deficits not present in normal animals similarly challenged. • Exaggerated sickness behav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16514e12e305dcb7d002bd410ef9f118