Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Edel A. McNeela"'
Autor:
Thanh Hoa Vo, Esam EL-Sherbieny Abdelaal, Emmet Jordan, Orla O'Donovan, Edel A. McNeela, Jai Prakash Mehta, Sweta Rani
Publikováno v:
Biochemistry and Biophysics Reports, Vol 37, Iss , Pp 101588- (2024)
Breast cancer is the most common type of lethal cancer in women globally. Women have a 1 in 8 chance of developing breast cancer in their lifetime. Among the four primary molecular subtypes (luminal A, luminal B, HER2+, and triple-negative), HER2+ ac
Externí odkaz:
https://doaj.org/article/f9e0922ebe34466f9119b0ac537bd412
Autor:
Edel A McNeela, Aine Burke, Daniel R Neill, Cathy Baxter, Vitor E Fernandes, Daniela Ferreira, Sarah Smeaton, Rana El-Rachkidy, Rachel M McLoughlin, Andres Mori, Barry Moran, Katherine A Fitzgerald, Jurg Tschopp, Virginie Pétrilli, Peter W Andrew, Aras Kadioglu, Ed C Lavelle
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001191 (2010)
Pneumolysin (PLY) is a key Streptococcus pneumoniae virulence factor and potential candidate for inclusion in pneumococcal subunit vaccines. Dendritic cells (DC) play a key role in the initiation and instruction of adaptive immunity, but the effects
Externí odkaz:
https://doaj.org/article/e10145540ddd48788b803169ff38aeef
Autor:
Craig P. McEntee, Vincenzo Aversa, Jan Holmgren, Mónica Rosa, Edel A. McNeela, Christopher J.H. Davitt, Joshua Tobias, Stephanie Longet, Ivan Coulter, Ed C. Lavelle
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 233
Diarrhoeal infections are a major cause of morbidity and mortality with enterotoxigenic Escherichia coli (ETEC) and cholera imposing a significant global burden. There is currently no licensed vaccine for ETEC. Development of new nonliving oral vacci
Autor:
Lidia Tajber, Yuki Ozasa, Ed C. Lavelle, Owen I. Corrigan, Fiona A. Sharp, Michelle Coleman, Ewa Oleszycka, Manmohan Singh, Andres Mori, Edel A. McNeela, Derek T. O'Hagan
Publikováno v:
European Journal of Immunology. 42:2709-2719
Alum is the principal vaccine adjuvant for clinical applications but it is a poor inducer of cellular immunity and is not an optimal adjuvant for vaccines where Th1 responses are required for protection. The mechanism underlying the inefficiency of a
Autor:
Frances Bowe, Christine Hale, Edel A. McNeela, Ed C. Lavelle, Rino Rappuoli, Simon Clare, Gordon Dougan, Beatrice Aricò, Alan Huett, Marzia Monica Giuliani, Aaron Rae, Kingston H. G. Mills
Publikováno v:
Infection and Immunity. 72:4052-4060
Conjugated polysaccharide vaccines protect against serogroup C meningococci. However, this approach cannot be applied to serogroup B, which is still a major cause of meningitis. We evaluated the immunogenicity of three surface-exposed proteins from s
Autor:
Kingston H. G. Mills, Audino Podda, Lisbeth Illum, Mariagrazia Pizza, Inderjit Jabbal-Gill, Rino Rappuoli, David J. M. Lewis, Edel A. McNeela
Publikováno v:
Vaccine. 22:909-914
We previously reported that intranasal immunization with a non-toxic mutant cross-reacting material (CRM)197 of diphtheria toxin, formulated with chitosan, generated protective neutralizing antibodies in mice and guinea pigs. Furthermore, we demonstr
Autor:
Ed C. Lavelle, Andrew G. Jarnicki, Edel A. McNeela, Olive Leavy, Sarah C. Higgins, Kingston H. G. Mills, Michelle E. Armstrong
Publikováno v:
Journal of Leukocyte Biology. 75:756-763
PUBLISHED
PMID: 14704372
Adenylate cyclase toxin (CyaA) from Bordetella pertussis can subvert host immune responses allowing bacterial colonization. Here we have examined its adjuvant and immunomodulatory properties and the possible contrib
PMID: 14704372
Adenylate cyclase toxin (CyaA) from Bordetella pertussis can subvert host immune responses allowing bacterial colonization. Here we have examined its adjuvant and immunomodulatory properties and the possible contrib
Autor:
Michelle E. Armstrong, Edel A. McNeela, Olive Leavy, Kingston H. G. Mills, Sarah C. Higgins, Ed C. Lavelle
Publikováno v:
The Journal of Immunology. 171:2384-2392
It has previously been reported that cholera toxin (CT) is a potent mucosal adjuvant that enhances Th2 or mixed Th1/Th2 type responses to coadministered foreign Ag. Here we demonstrate that CT also promotes the generation of regulatory T (Tr) cells a
Autor:
Arpad Pusztai, Kingston H. G. Mills, Olive Leavy, Ed C. Lavelle, Derek T. O'Hagan, George Grant, U. Pfüller, Edel A. McNeela
Publikováno v:
Immunology. 107:268-274
SUMMARY The mucosal adjuvant properties of the three type 2 ribosome-inactivating proteins (RIPs) from the European mistletoe, Viscum album L., were investigated. Mistletoe lectins were compared with cholera toxin (CT) as adjuvants when delivered nas
Autor:
Kin Chan, John P. Fox, Timothy J. Foster, Nicolas Collin, Simon Heuking, Ed C. Lavelle, Rachel M. McLoughlin, Alison G. Murphy, Kate M. O’Keeffe, Joan A. Geoghegan, Karen Misstear, Edel A. McNeela
Publikováno v:
Journal of Infectious Diseases, vol. 209, no. 9, pp. 1479-1484
Despite showing promise in preclinical models, anti-Staphylococcus aureus vaccines have failed in clinical trials. To date, approaches have focused on neutralizing/opsonizing antibodies; however, vaccines exclusively inducing cellular immunity have n