Výsledky vyhledávání - "Eddy Vlaminckx"

Direct effects of arsenic trioxide on action potentials in isolated cardiac tissues: Importance of the choice of species, type of cardiac tissue and perfusion time

Autor: Eddy Vlaminckx, Frank Cools, Hua Rong Lu, David J. Gallacher

Publikováno v: Journal of Pharmacological and Toxicological Methods. 66:135-144

Introduction The aim of the present study was to evaluate direct/acute effects of arsenic trioxide on action potentials (APs) in isolated cardiac tissues, and to investigate if the choice of species and tissue and the duration of the perfusion play a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52794933c6e408a4122b97330d181af6
https://doi.org/10.1016/j.vascn.2012.03.002

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Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the ‘bad’ sodium current blockers

Autor: Karel Van Ammel, Gan-Xin Yan, Hua Rong Lu, Eddy Vlaminckx, David J. Gallacher, Jutta Rohrbacher

Publikováno v: British Journal of Pharmacology. 160:60-76

Background and purpose: The regulatory guidelines (ICHS7B) for the identification of only drug-induced long QT and pro-arrhythmias have certain limitations. Experimental approach: Conduction time (CT) was measured in isolated Purkinje fibres, left ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4100c56b9d57571883858a18c6cf0a71
https://doi.org/10.1111/j.1476-5381.2010.00646.x

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Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines

Autor: Michael K. Pugsley, Eddy Vlaminckx, An N. Hermans, K. Van Ammel, H.R. Lu, Jutta Rohrbacher, David J. Gallacher, Rob Towart

Publikováno v: British Journal of Pharmacology. 154:1427-1438

Background and purpose: The regulatory guidelines (ICHS7B) recommending inhibition of the delayed rectifier K+ current (IKr), carried by human ether-a-go-go-related gene (hERG) channels in cardiac cells (the hERG test), as a ‘first line’ test for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07c19411dfcbc17ca51dca9735485021
https://doi.org/10.1038/bjp.2008.191

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Choice of cardiac tissue in vitro plays an important role in assessing the risk of drug-induced cardiac arrhythmias in human: Beyond QT prolongation

Autor: Hua Rong Lu, David J. Gallacher, Eddy Vlaminckx

Publikováno v: Journal of Pharmacological and Toxicological Methods. 57:1-8

Introduction Recently we have demonstrated that to the choice of tissue type is important in identifying IKr and IKs-induced prolongation of the action potential. However, the differential sensitivity of cardiac tissues to other ionic current blocker

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ca8ed69aae435d9bf5895eef0021cd
https://doi.org/10.1016/j.vascn.2007.06.005

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Corrigendum to 'In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation'

Autor: David J. Gallacher, Jutta Rohrbacher, Andre Van de Water, Hua Rong Lu, An N. Hermans, Eddy Vlaminckx

Publikováno v: European Journal of Pharmacology. 577:222-232

The prolongation of the ventricular repolarization and proarrhythmic effects (Torsade de Pointes: TdP) of five reference antibiotics were compared in four in-vitro models. 1. Using the patch clamp technique on the human ether-a-gogo-related gene (HER

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6f0772321fa3ef6fc45b4839815fe60
https://doi.org/10.1016/j.ejphar.2007.07.070

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Choice of cardiac tissue plays an important role in the evaluation of drug-induced prolongation of the QT interval in vitro in rabbit

Autor: Ard Teisman, Hua Rong Lu, Eddy Vlaminckx, David J. Gallacher

Publikováno v: Journal of Pharmacological and Toxicological Methods. 52:90-105

Introduction Regulatory guidelines (CPMP/986/96, ICHS7B) recommend the use of isolated cardiac tissues, including Purkinje fibers, papillary muscles and ventricular trabeculae, for detecting potential drug-induced long QT. However, the differential s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e16830814b1cdfb0b3e04ddcf52c5a
https://doi.org/10.1016/j.vascn.2005.04.007

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QT and JT dispersion in the drug-induced long QT syndrome in anaesthetized rabbits is accurately detected by a three-lead surface ECG measurement

Autor: Eddy Vlaminckx, K. Van Ammel, H.R. Lu, F. De Clerck

Publikováno v: Journal of Pharmacological and Toxicological Methods. 49:71-79

Introduction: QT dispersion (QTd) can be measured from three leads of the ECG in patients with myocardial ischemia. However, whether QT and JT dispersion (QTd, JTd) can be calculated from a three-lead of the ECG in drug-induced long QT syndrome (LQTS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5166948554ed98499df2e0f999cfe5e5
https://doi.org/10.1016/j.vascn.2003.10.003

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