Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Eddy Demarsin"'
Publikováno v:
Blood. 96:1425-1432
Site directed mutagenesis (350 variants) of recombinant staphylokinase (SakSTAR), a potent fibrin-selective thrombolytic agent, was undertaken in order to reduce its antigenicity while maintaining its potency. Variants with K35A, (ie, Lys[K] in posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bfc78b6c80e03a4719355b50167f29
https://doi.org/10.1182/blood.v96.4.1425.h8001425_1425_1432
https://doi.org/10.1182/blood.v96.4.1425.h8001425_1425_1432
Autor:
J. P. Roodt, Muriel Meiring, Philippe Barbeaux, Eddy Demarsin, Alexandre Fontayne, Seb Lamprecht, Hans Deckmyn
Publikováno v:
Thrombosis and haemostasis. 100(4)
SummaryThe Fab-fragment of 6B4, a murine monoclonal antibody targeting the human platelet glycoprotein (GP) Ibα and blocking the binding of von Willebrand factor (VWF), is a powerful antithrombotic. In baboons, this was without side effects such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5d8ce5a079a5200bad2ae434fb9f54
https://pubmed.ncbi.nlm.nih.gov/18841291
https://pubmed.ncbi.nlm.nih.gov/18841291
Autor:
Marc De Maeyer, Eddy Demarsin, H Moreau, Yves Laroche, Desire Collen, Frans Van de Werf, Laurent Jespers, Peter Sinnaeve
Publikováno v:
Circulation. 102(15)
Background —Thrombolytic therapy of acute myocardial infarction (AMI) is evolving toward bolus administration. Derivatization of proteins with polyethylene glycol (PEG) may reduce their clearance. Methods and Results —A staphylokinase (SakSTAR) v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ee7213c3a9723d56a654fb010eb318
https://pubmed.ncbi.nlm.nih.gov/11023930
https://pubmed.ncbi.nlm.nih.gov/11023930
Publikováno v:
Blood. 69:592-596
The specific thrombolytic properties of urokinase and three molecular forms of single-chain urokinase-type plasminogen activator (scu-PA) were compared in a human plasma milieu in vitro and in an experimental thrombosis model in rabbits. These scu-PA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13a05ba944a2226af3aeca711aa52561
https://doi.org/10.1182/blood.v69.2.592.592
https://doi.org/10.1182/blood.v69.2.592.592