Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Eddy, Sotelo"'
Autor:
Rubén Prieto-Díaz, Hugo Fojo-Carballo, Maria Majellaro, Tana Tandarić, Jhonny Azuaje, José Brea, María I. Loza, Jorge Barbazán, Glòria Salort, Meera Chotalia, Iván Rodríguez-Pampín, Ana Mallo-Abreu, M. Rita Paleo, Xerardo García-Mera, Francisco Ciruela, Hugo Gutiérrez-de-Terán, Eddy Sotelo
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116345- (2024)
Antagonists of the A2B adenosine receptor have recently emerged as targeted anticancer agents and immune checkpoint inhibitors within the realm of cancer immunotherapy. This study presents a comprehensive evaluation of novel Biginelli-assembled pyrim
Externí odkaz:
https://doaj.org/article/49588aec46c84378975a623bef5f1ed4
Autor:
Claudia Gioé-Gallo, Sandra Ortigueira, José Brea, Iu Raïch, Jhonny Azuaje, M. Rita Paleo, Maria Majellaro, María Isabel Loza, Cristian O. Salas, Xerardo García-Mera, Gemma Navarro, Eddy Sotelo
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114934- (2023)
Synthetic cannabinoid receptor agonists (SCRAs) constitute the largest and most defiant group of abuse designer drugs. These new psychoactive substances (NPS), developed as unregulated alternatives to cannabis, have potent cannabimimetic effects and
Externí odkaz:
https://doaj.org/article/3b0ddeb6be494b4382e24224b8f69591
Autor:
Miguel Pereira-Silva, Darío Miranda-Pastoriza, Luis Diaz-Gomez, Eddy Sotelo, Ana Cláudia Paiva-Santos, Francisco Veiga, Angel Concheiro, Carmen Alvarez-Lorenzo
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 95 (2024)
Pancreatic cancer (PC) is an aggressive cancer subtype presenting unmet clinical challenges. Conventional chemotherapy, which includes antimetabolite gemcitabine (GEM), is seriously undermined by a short half-life, its lack of targeting ability, and
Externí odkaz:
https://doaj.org/article/54f63efc863043fd89f53b58e67023be
Publikováno v:
Molecules, Vol 28, Iss 24, p 8107 (2023)
The identification of new modulators for Cannabinoid Receptors (CBRs) has garnered significant attention in drug discovery over recent years, owing to their manifold pathophysiological implications. In the context of hit identification, the availabil
Externí odkaz:
https://doaj.org/article/b984db540fcc45b38c1ff849fd3cbb3b
Autor:
Maris-Johanna Tahk, Tõnis Laasfeld, Elo Meriste, Jose Brea, Maria Isabel Loza, Maria Majellaro, Marialessandra Contino, Eddy Sotelo, Ago Rinken
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Dopamine receptors are G-protein-coupled receptors that are connected to severe neurological disorders. The development of new ligands targeting these receptors enables gaining a deeper insight into the receptor functioning, including binding mechani
Externí odkaz:
https://doaj.org/article/22db54a4222f4329a1d283cd834504c0
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113408- (2022)
G-protein coupled receptors (GPCRs) have been largely targeted in a wide range of diseases, but few therapies have been directed against GPCRs in the field of cancer, partly because of the lack of effective target identification strategies. Here, usi
Externí odkaz:
https://doaj.org/article/86caa106e5c64ceb88e9ea66d01167db
Autor:
Xuesong Wang, Willem Jespers, Rubén Prieto-Díaz, Maria Majellaro, Adriaan P. IJzerman, Gerard J. P. van Westen, Eddy Sotelo, Laura H. Heitman, Hugo Gutiérrez-de-Terán
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The four adenosine receptors (ARs) A1AR, A2AAR, A2BAR, and A3AR are G protein-coupled receptors (GPCRs) for which an exceptional amount of experimental and structural data is available. Still, limited success has been achieved in getting new
Externí odkaz:
https://doaj.org/article/e3d7468f1f4048819ea81f585f212118
Autor:
Andreas Lundqvist, Felix Haglund, Johan Hartman, Björn Önfelt, Apple Hui Min Tay, Rubén Prieto-Díaz, Shiyong Neo, Le Tong, Xinsong Chen, Valentina Carannante, Maria Majellaro, Jhonny Azuaje, Xerardo Garcia-Mera, Jose M Brea, Maria I Loza, Willem Jespers, Hugo Gutierrez-de-Teran, Eddy Sotelo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 5 (2022)
Background Adenosine is a metabolite that suppresses antitumor immune response of T and NK cells via extracellular binding to the two subtypes of adenosine-2 receptors, A2ARs. While blockade of the A2AARs subtype effectively rescues lymphocyte activi
Externí odkaz:
https://doaj.org/article/459b1040db484d5f931d73069318670c
Autor:
Willem Jespers, Laura H Heitman, Adriaan P IJzerman, Eddy Sotelo, Gerard J P van Westen, Johan Åqvist, Hugo Gutiérrez-de-Terán
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 11, p e1009152 (2021)
Transmembranal G Protein-Coupled Receptors (GPCRs) transduce extracellular chemical signals to the cell, via conformational change from a resting (inactive) to an active (canonically bound to a G-protein) conformation. Receptor activation is normally
Externí odkaz:
https://doaj.org/article/ed5e77758ad342f7b032db580b22f1c5
Autor:
Francesca Serena Abatematteo, Maria Majellaro, Bianca Montsch, Rubén Prieto-Díaz, Mauro Niso, Marialessandra Contino, Angela Stefanachi, Chiara Riganti, Giuseppe Felice Mangiatordi, Pietro Delre, Petra Heffeter, Eddy Sotelo, Carmen Abate
Publikováno v:
Journal of Medicinal Chemistry. 66:3798-3817
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30f33e4a62ecd725b0aecdea641f94a7
https://doi.org/10.1021/acs.jmedchem.2c01227
https://doi.org/10.1021/acs.jmedchem.2c01227