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Structural characterization of M8C10, a neutralizing antibody targeting a highly conserved prefusion-specific epitope on the metapneumovirus fusion trimerization interface.

Autor: Xiao X; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, Pennsylvania, USA.; Discovery Biologics, Merck & Co., Inc., Boston, Massachusetts, USA.; MRL Postdoctoral Research Program, Merck & Co., Inc., Kenilworth, New Jersey, USA., Wen Z; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, Pennsylvania, USA., Chen Q; Protein and Structural Chemistry, Merck & Co., Inc., West Point, Pennsylvania, USA., Shipman JM; Protein and Structural Chemistry, Merck & Co., Inc., West Point, Pennsylvania, USA., Kostas J; Protein and Structural Chemistry, Merck & Co., Inc., West Point, Pennsylvania, USA., Reid JC; Protein and Structural Chemistry, Merck & Co., Inc., West Point, Pennsylvania, USA., Warren C; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, Pennsylvania, USA., Tang A; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, Pennsylvania, USA., Luo B; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania, USA., O'Donnell G; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania, USA., Fridman A; Data Science and Scientific Informatics, Merck & Co., Inc., Rahway, New Jersey, USA., Chen Z; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, Pennsylvania, USA., Vora KA; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, Pennsylvania, USA., Zhang L; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, Pennsylvania, USA., Su H-P; Protein and Structural Chemistry, Merck & Co., Inc., West Point, Pennsylvania, USA., Eddins MJ; Protein and Structural Chemistry, Merck & Co., Inc., West Point, Pennsylvania, USA.

Publikováno v: Journal of virology [J Virol] 2023 Dec 21; Vol. 97 (12), pp. e0105223. Date of Electronic Publication: 2023 Nov 30.

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Akademický článek

Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases.

Autor: Kleiner VA; Department of Virology, Immunology & Microbiology, National Emerging Infectious Diseases Laboratories, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., O Fischmann T; MRL, Merck & Co., Inc., Rahway, NJ, USA., Howe JA; MRL, Merck & Co., Inc., Rahway, NJ, USA., Beshore DC; MRL, Merck & Co., Inc., Rahway, NJ, USA., Eddins MJ; MRL, Merck & Co., Inc., Rahway, NJ, USA., Hou Y; MRL, Merck & Co., Inc., Rahway, NJ, USA., Mayhood T; MRL, Merck & Co., Inc., Rahway, NJ, USA., Klein D; MRL, Merck & Co., Inc., Rahway, NJ, USA., Nahas DD; MRL, Merck & Co., Inc., Rahway, NJ, USA., Lucas BJ; MRL, Merck & Co., Inc., Rahway, NJ, USA., Xi H; MRL, Merck & Co., Inc., Rahway, NJ, USA., Murray E; MRL, Merck & Co., Inc., Rahway, NJ, USA., Ma DY; MRL, Merck & Co., Inc., Rahway, NJ, USA., Getty K; MRL, Merck & Co., Inc., Rahway, NJ, USA., Fearns R; Department of Virology, Immunology & Microbiology, National Emerging Infectious Diseases Laboratories, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA. rfearns@bu.edu.

Publikováno v: Communications biology [Commun Biol] 2023 Jun 19; Vol. 6 (1), pp. 649. Date of Electronic Publication: 2023 Jun 19.

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Akademický článek

Profiling of hMPV F-specific antibodies isolated from human memory B cells.

Autor: Xiao X; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, PA, USA.; Discovery Biologics, Merck & Co., Inc., Boston, MA, USA.; MRL Postdoctoral Research Program; Merck & Co., Inc., Kenilworth, NJ, USA., Fridman A; Data Science and Scientific Informatics, Merck & Co., Inc., Rahway, NJ, USA., Zhang L; Bioinformatics and Biomarker Research, MSD, Beijing, China., Pristatsky P; Analytical Research and Development, Merck & Co., Inc., West Point, PA, USA., Durr E; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, PA, USA., Minnier M; AgileOne, Torrence, CA, USA., Tang A; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, PA, USA., Cox KS; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, PA, USA., Wen Z; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, PA, USA., Moore R; Discovery Biologics, Merck & Co., Inc., Boston, MA, USA., Tian D; Wuxi Biortus Biosciences Co. Ltd., Wuxi, China., Galli JD; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, PA, USA., Cosmi S; Eurofins PSS Insourcing Solutions, Lancaster, PA, USA., Eddins MJ; Computational and Structural Chemistry, Merck & Co., Inc., West Point, PA, USA., Sullivan NL; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, PA, USA., Yan X; Wuxi Biortus Biosciences Co. Ltd., Wuxi, China., Bett AJ; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, PA, USA., Su HP; Computational and Structural Chemistry, Merck & Co., Inc., West Point, PA, USA., Vora KA; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, PA, USA. kalpit.vora@merck.com., Chen Z; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, PA, USA. zhifeng.chen@merck.com., Zhang L; Infectious Diseases and Vaccines Discovery, Merck & Co., Inc., West Point, PA, USA. lan_zhang2@merck.com.

Publikováno v: Nature communications [Nat Commun] 2022 May 10; Vol. 13 (1), pp. 2546. Date of Electronic Publication: 2022 May 10.

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Discovery of a new class of integrin antibodies for fibrosis.

Autor: Zhang J; Departments of Cardiometabolic Diseases, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA. ji.zhang1@alumni.duke.edu., Wang T; Discovery Biologics, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Saigal A; Departments of Cardiometabolic Diseases, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Johnson J; Quantitative Biosciences, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Morrisson J; Discovery Biologics, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Tabrizifard S; Discovery Biologics, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Hollingsworth SA; Computational & Structural Chemistry, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Eddins MJ; Computational & Structural Chemistry, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Mao W; Quantitative Biosciences, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., O'Neill K; In Vitro Pharmacology, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Garcia-Calvo M; In Vitro Pharmacology, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Carballo-Jane E; Quantitative Biosciences, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Liu D; SALAR, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Ham T; SALAR, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Zhou Q; SALAR, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Dong W; SALAR, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Meng HW; Discovery Biologics, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Hicks J; Discovery Chemistry, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Cai TQ; In Vivo Pharmacology, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Akiyama T; Departments of Cardiometabolic Diseases, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Pinto S; Departments of Cardiometabolic Diseases, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Cheng AC; Computational & Structural Chemistry, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Greshock T; Discovery Chemistry, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Marquis JC; Discovery Biologics, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Ren Z; Quantitative Biosciences, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Talukdar S; Departments of Cardiometabolic Diseases, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Shaheen HH; Discovery Biologics, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Handa M; Discovery Biologics, MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA. masahisa.handa@merck.com.

Publikováno v: Scientific reports [Sci Rep] 2021 Jan 22; Vol. 11 (1), pp. 2118. Date of Electronic Publication: 2021 Jan 22.

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Akademický článek

Discovery of Therapeutic Deubiquitylase Effector Molecules: Current Perspectives.

Autor: Nicholson B; Progenra, Inc., Malvern, PA, USA., Kumar S; Progenra, Inc., Malvern, PA, USA., Agarwal S; Progenra, Inc., Malvern, PA, USA., Eddins MJ; Progenra, Inc., Malvern, PA, USA., Marblestone JG; Progenra, Inc., Malvern, PA, USA., Wu J; Progenra, Inc., Malvern, PA, USA., Kodrasov MP; Progenra, Inc., Malvern, PA, USA., LaRocque JP; Progenra, Inc., Malvern, PA, USA., Sterner DE; Progenra, Inc., Malvern, PA, USA., Mattern MR; Progenra, Inc., Malvern, PA, USA mattern@progenra.com.

Publikováno v: Journal of biomolecular screening [J Biomol Screen] 2014 Aug; Vol. 19 (7), pp. 989-99. Date of Electronic Publication: 2014 Mar 14.

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