Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Eddine Saiah"'
Autor:
Sophie St-Cyr, Daniel D Child, Emilie Giaime, Alicia R Smith, Christine J Pascua, Seung Hahm, Eddine Saiah, Beverly L Davidson
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273710 (2022)
Huntington's Disease (HD) is a dominantly inherited neurodegenerative disease for which the major causes of mortality are neurodegeneration-associated aspiration pneumonia followed by cardiac failure. mTORC1 pathway perturbations are present in HD mo
Externí odkaz:
https://doaj.org/article/5daa31f88c0a405a978f93c37b33aa4c
Autor:
Sarah J. Mahoney, Sridhar Narayan, Lisa Molz, Lauren A. Berstler, Seong A. Kang, George P. Vlasuk, Eddine Saiah
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Aberrant mTORC1 signaling is linked to several chronic diseases. Here, the authors develop a small molecule inhibitor that binds the small G-protein Rheb and selectively blocks mTORC1 signaling, holding potential for therapeutic applications.
Externí odkaz:
https://doaj.org/article/e4e93d6c676242c793f6e0e9b9280186
Autor:
Dafydd R. Owen, James D. Clark, Xiaojing Yang, Eddine Saiah, Martin Hegen, Brian S. Gerstenberger, Felix Vajdos, Catherine M. Ambler, Li Xing, Alpay Dermenci, Tsung H. Lin, Matthew Merrill Hayward, Raman Sharma, Xin Yang, David W. Lin, John D. Knafels, Eric P. Arnold, Mary-Ellen Banker, Stephen W. Wright, Martin E. Dowty, Brett D. Hollingshead, Andrew Fensome, Susan Fish, Matthew Frank Brown
Publikováno v:
Journal of medicinal chemistry. 63(22)
Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family that regulates signal transduction downstream of receptors for the IL-23/IL-12 pathways and type I interferon family, where it pairs with JAK2 or JAK1, respectively. On the basis of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62513b08e1117b54db6ce345e9512f36
https://pubmed.ncbi.nlm.nih.gov/32787094
https://pubmed.ncbi.nlm.nih.gov/32787094
Autor:
Brett D. Hollingshead, Fabien Vincent, Tsung H. Lin, John I. Trujillo, Betsy Pierce, Andrew Fensome, Brian S. Gerstenberger, Martin E. Dowty, Matthew Frank Brown, Xin Yang, David C. Limburg, Martin Hegen, John D. Knafels, Felix Vajdos, Andrew C. Flick, Mary Ellen Banker, Raman Sharma, Li Xing, Jason Jussif, Catherine M. Ambler, Ivan Viktorovich Efremov, James D. Clark, Liying Zhang, Peter T. Symanowicz, Eddine Saiah, Jill Chrencik, Jean-Baptiste Telliez, Xiaojing Yang, Eric P. Arnold, Ariamala Gopalsamy, Zhao-Kui Wan, Matthew Merrill Hayward, David W. Lin
Publikováno v:
Journal of Medicinal Chemistry. 61:8597-8612
Cytokine signaling is an important characteristic of autoimmune diseases. Many pro-inflammatory cytokines signal through the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) pathway. JAK1 is important for the γ-common chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d4f153dbb8b5bb68fb24a9742305143
https://doi.org/10.1021/acs.jmedchem.8b00917
https://doi.org/10.1021/acs.jmedchem.8b00917
Autor:
Lori Krim Gavrin, David Hepworth, Jennifer R. Thomason, Iain Kilty, Joel Adam Goldberg, Christoph W. Zapf, Vikram R. Rao, Brian P. Boscoe, Akshay Patny, Peter T. Symanowicz, Marina W.H. Shen, Kevin J. Curran, Elizabeth Murphy, Martin Hegen, Fabien Vincent, Richard Vargas, Satwik Kamtekar, Heidi M. Morgan, Heidi R. Hope, Richard K. Frisbie, Jeanne S. Chang, Ken Dower, Susan E. Drozda, Strohbach Joseph Walter, Mathias John Paul, David R. Anderson, Jacqueline E. Day, Stephen W. Wright, Ivan J. Samardjiev, Seungil Han, Julia H Shin, Frank Lovering, Andrea G Bree, Arthur Lee, Holly H. Soutter, Joanne Brodfuehrer, John David Trzupek, Brian Samas, Christoph Martin Dehnhardt, Michael Dennis Lowe, Catherine M. Ambler, Seung Won Chung, Eddine Saiah, Nikolaos Papaioannou, Pierce Betsy S, Jiangli Yan, Katherine L. Lee, Lih-Ling Lin, Chulho Choi
Publikováno v:
Journal of Medicinal Chemistry. 60:5521-5542
Through fragment-based drug design focused on engaging the active site of IRAK4 and leveraging three-dimensional topology in a ligand-efficient manner, a micromolar hit identified from a screen of a Pfizer fragment library was optimized to afford IRA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d71e108dde9e50f577dacbc8e3364e
https://doi.org/10.1021/acs.jmedchem.7b00231
https://doi.org/10.1021/acs.jmedchem.7b00231
Autor:
Catharine H. Duman, George P. Vlasuk, Taro Kato, Santosh Pothula, Rong-Jian Liu, Eddine Saiah, Seung Hahm, Ronald S. Duman, Rosemarie Terwilliger
Publikováno v:
J Clin Invest
Preclinical studies demonstrate that rapid-acting antidepressants, including ketamine, require stimulation of mTORC1 signaling. This pathway is regulated by neuronal activity and endocrine and metabolic signals, notably including the amino acid leuci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bc335f8b180901f671e2f0efb2f1c7
https://europepmc.org/articles/PMC6546461/
https://europepmc.org/articles/PMC6546461/
Autor:
Emilie Giaime, George P. Vlasuk, Jessica J. Howell, Shomit Sengupta, Seung Hahm, David John O'neill, Eddine Saiah, Sridhar Narayan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
The mechanistic target of rapamycin complex 1 (mTORC1) has been linked to several important chronic medical conditions many of which are associated with advancing age. A variety of inputs including the amino acid leucine are required for full mTORC1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6678722f6226c83bc4a70778e2d4d3
https://doi.org/10.1038/s41598-019-40693-5
https://doi.org/10.1038/s41598-019-40693-5
Autor:
Andrew, Fensome, Catherine M, Ambler, Eric, Arnold, Mary Ellen, Banker, Matthew F, Brown, Jill, Chrencik, James D, Clark, Martin E, Dowty, Ivan V, Efremov, Andrew, Flick, Brian S, Gerstenberger, Ariamala, Gopalsamy, Matthew M, Hayward, Martin, Hegen, Brett D, Hollingshead, Jason, Jussif, John D, Knafels, David C, Limburg, David, Lin, Tsung H, Lin, Betsy S, Pierce, Eddine, Saiah, Raman, Sharma, Peter T, Symanowicz, Jean-Baptiste, Telliez, John I, Trujillo, Felix F, Vajdos, Fabien, Vincent, Zhao-Kui, Wan, Li, Xing, Xiaojing, Yang, Xin, Yang, Liying, Zhang
Publikováno v:
Journal of medicinal chemistry. 61(19)
Cytokine signaling is an important characteristic of autoimmune diseases. Many pro-inflammatory cytokines signal through the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) pathway. JAK1 is important for the γ-common chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad2ad9462488003d246ff771f1250154
https://pubmed.ncbi.nlm.nih.gov/30113844
https://pubmed.ncbi.nlm.nih.gov/30113844
Autor:
Lauren A. Berstler, Sarah J. Mahoney, George P. Vlasuk, Sridhar Narayan, Eddine Saiah, Seong A. Kang, Lisa Molz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
The small G-protein Rheb activates the mechanistic target of rapamycin complex 1 (mTORC1) in response to growth factor signals. mTORC1 is a master regulator of cellular growth and metabolism; aberrant mTORC1 signaling is associated with fibrotic, met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79821839bb734d9a67167aa43008928e
https://doi.org/10.1038/s41467-018-03035-z
https://doi.org/10.1038/s41467-018-03035-z
Autor:
Eddine Saiah, George P. Vlasuk, Seong A. Kang, Stephanie N. Galda, Shomit Sengupta, Jessica J. Howell, Lisa Molz, David John O'neill, Sarah J. Mahoney, Andreas W. Machl, Seung Hahm, Casey J. Lumpkin
Publikováno v:
Cell Chemical Biology. 26:1203-1213.e13
Summary The mechanistic target of rapamycin (mTOR) is a central regulator of cellular metabolic processes. Dysregulation of this kinase complex can result in a variety of human diseases. Rapamycin and its analogs target mTORC1 directly; however, chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e4e82f2a630644712668cbd876df78
https://doi.org/10.1016/j.chembiol.2019.05.009
https://doi.org/10.1016/j.chembiol.2019.05.009