Výsledky vyhledávání

Scalable, Telescoped Hydrogenolysis–Enzymatic Decarboxylation Process for the Asymmetric Synthesis of (R)-α-Heteroaryl Propionic Acids

Autor: Caroline A. Blakemore, Scott P. France, Lacey Samp, Deane M. Nason, Eddie Yang, Roger M. Howard, Karen J. Coffman, Qingyi Yang, Aaron C. Smith, Edelweiss Evrard, Wei Li, Linlin Dai, Lixia Yang, Zhiguang Chen, Qingli Zhang, Fangyan He, Jiesen Zhang

Publikováno v: Organic Process Research & Development. 25:421-426

Enantiopure α-aryl propionic acids are useful building blocks for pharmaceutical research and can be accessed enzymatically using arylmalonate decarboxylases (AMDases) from the corresponding maloni...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95e6ff3e3df541e059c49547d26b4819
https://doi.org/10.1021/acs.oprd.0c00397

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Hierarchically Regularized Entropy Balancing

Autor: Eddie Yang, Yiqing Xu

Publikováno v: SSRN Electronic Journal.

We introduce hierarchically regularized entropy balancing as an extension to entropy balancing, a reweighting method that adjusts weights for control group units to achieve covariate balance in observational studies with binary treatments. Our propos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffd2afbc46bcc1f5426b769ce163fa7
https://doi.org/10.2139/ssrn.3807620

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Censorship of Online Encyclopedias: Implications for NLP Models

Autor: Eddie Yang, Margaret E. Roberts

Publikováno v: FAccT

While artificial intelligence provides the backbone for many tools people use around the world, recent work has brought to attention that the algorithms powering AI are not free of politics, stereotypes, and bias. While most work in this area has foc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03809346ee7bf0d62a9276467be4cbd9

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Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1

Autor: Eddie Yang, Jennifer L. Liras, Christine C. Orozco, Christopher W. am Ende, Matthew A. Movsesian, Jayvardhan Pandit, John M. Humphrey, Stephen Jenkinson, Frank S. Menniti, Thomas Allen Chappie, Spiros Liras, Stacey L. Becker, Felix Vajdos, Fabrice Vandeput

Publikováno v: Journal of medicinal chemistry. 61(10)

We disclose the discovery and X-ray cocrystal data of potent, selective quinazoline inhibitors of PDE1. Inhibitor (S)-3 readily attains free plasma concentrations above PDE1 IC50 values and has restricted brain access. The racemic compound 3 inhibits

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad70863e6c50adf198b09386b95c77c
https://pubmed.ncbi.nlm.nih.gov/29718668

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Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1

Autor: Artem G. Evdokimov, John M. Humphrey, Christopher W. am Ende, Brian Samas, Lorraine A. Lebel, Frank S. Menniti, Mahmoud N. Mansour, Eddie Yang, Eric P. Arnold, Stephen Jenkinson, Spiros Liras, Felix Vajdos, Jenna L. Head, Samuel P. Simons, Jayvardhan Pandit

Publikováno v: Med. Chem. Commun.. 5:1290-1296

PDE1 is a family of calcium-activated, dual substrate phosphodiesterases expressed in both the CNS and periphery that play a role in the integration of intracellular calcium and cyclic nucleotide signaling cascades. Exploration of the potential in ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aee7e61fad4cc33141361751d7d3b803
https://doi.org/10.1039/c4md00113c

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