Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Eddie Clutton"'
Autor:
Hemanth R. Nelvagal, Samantha L. Eaton, Sophie H. Wang, Elizabeth M. Eultgen, Keigo Takahashi, Steven Q. Le, Rachel Nesbitt, Joshua T. Dearborn, Nicholas Siano, Ana C. Puhl, Patricia I. Dickson, Gerard Thompson, Fraser Murdoch, Paul M. Brennan, Mark Gray, Stephen N. Greenhalgh, Peter Tennant, Rachael Gregson, Eddie Clutton, James Nixon, Chris Proudfoot, Stefano Guido, Simon G. Lillico, C. Bruce A. Whitelaw, Jui-Yun Lu, Sandra L. Hofmann, Sean Ekins, Mark S. Sands, Thomas M. Wishart, Jonathan D. Cooper
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 20 (2022)
CLN1 disease, also called infantile neuronal ceroid lipofuscinosis (NCL) or infantile Batten disease, is a fatal neurodegenerative lysosomal storage disorder resulting from mutations in the CLN1 gene encoding the soluble lysosomal enzyme palmitoyl-pr
Externí odkaz:
https://doaj.org/article/fb7adb2cd6174d5a9c38555ece25def7
Autor:
Fraser Stewart, Gerard Cummins, Mihnea V. Turcanu, Benjamin F. Cox, Alan Prescott, Eddie Clutton, Ian P. Newton, Marc P. Y. Desmulliez, Maya Thanou, Helen Mulvana, Sandy Cochran, Inke Näthke
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Biologic drugs, defined as therapeutic agents produced from or containing components of a living organism, are of growing importance to the pharmaceutical industry. Though oral delivery of medicine is convenient, biologics require invasive i
Externí odkaz:
https://doaj.org/article/8a687ae1f41f4e86a9b87525b6ae78db
Publikováno v:
Ashall, V, Morton, D & Clutton, E 2023, ' A Declaration of Helsinki for animals ', Veterinary Anaesthesia and Analgesia, vol. 50, no. 4, 50, pp. 309-314 . https://doi.org/10.1016/j.vaa.2023.03.005
This article examines the ethical principles underlying the Declaration of Helsinki as an internationally agreed justificatory framework for human medical research. The aim of the analysis is to consider the potential usefulness of these principles f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c1fa95ecb2da5733599d1f07aa5c52
https://doi.org/10.1016/j.vaa.2023.03.005
https://doi.org/10.1016/j.vaa.2023.03.005
Publikováno v:
Novak, A, Shaw, D & Clutton, E 2022, ' Animal Welfare Requirements in Publishing Guidelines ', Laboratory Animals, vol. 56, no. 6, 236772221097825, pp. 561-575 . https://doi.org/10.1177/00236772221097825
Descriptions of measures taken to optimize animal welfare are often absent from scientific reports of animal experiments. One reason may be that journal guidelines inadequately compel authors to provide such information. In this study, online English
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239cbc1fa11dac071e62e77bbf05c984
https://www.pure.ed.ac.uk/ws/files/284655944/00236772221097825.pdf
https://www.pure.ed.ac.uk/ws/files/284655944/00236772221097825.pdf
Autor:
R. Eddie Clutton
Publikováno v:
Animals, Vol 10, Iss 10, p 1933 (2020)
Previous histories of animal experimentation, e.g., Franco (2013) have focused on ethics, the law and the personalities involved, but not on the involvement of anaesthetics or analgesics. Given that these were major subjects of (UK) Parliamentary deb
Externí odkaz:
https://doaj.org/article/fec4a36e947c4623847700801506bc92
Autor:
Hannah Esser, John M. Hallett, Karen Faulds, Fiona Hunt, Timothy J. Kendall, Rachael Gregson, Gabriel C. Oniscu, Lauren E. Jamieson, R Eddie Clutton, Colin Campbell, Katherine J.I. Ember, Stuart J. Forbes
Publikováno v:
Ember, K J I, Hunt, F, Jamieson, L E, Hallett, J M, Esser, H, Kendall, T J, Clutton, R E, Gregson, R, Faulds, K, Forbes, S J, Oniscu, G C & Campbell, C J 2021, ' Noninvasive Detection of Ischemic Vascular Damage in a Pig Model of Liver Donation After Circulatory Death ', Hepatology, vol. 74, no. 1, pp. 428-443 . https://doi.org/10.1002/hep.31701
BACKGROUND AND AIMS: Liver graft quality is evaluated by visual inspection prior to transplantation, a process highly dependent on surgeon's experience. We present an objective, non-invasive, quantitative way of assessing liver quality in real time u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b903b743cff53c96b1b1349d1ade6d39
https://doi.org/10.1002/hep.31701
https://doi.org/10.1002/hep.31701
Autor:
David Morton, Kate Allen, Beth Jinks, Mike Herrtage, Michael Clark, Richard Lea, Eddie Clutton, Kiterie Faller, Stephen Greenhalgh, Peter Fordyce, Sarah Wolfensohn, Chris Stevens, Pamela Gillick, Nicola Menzies‐Gow, David Killick, Joanna Morris, David Martin, Luisa De Risio, Jo Murrell
Publikováno v:
Veterinary Record. 192:174-175
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aec2af055402686b158831e27c7401ad
https://doi.org/10.1002/vetr.2761
https://doi.org/10.1002/vetr.2761
Autor:
Eddleston, Michael, Street, Jonathan M., Self, Ian, Thompson, Adrian, King, Tim, Williams, Nicola, Naredo, Gregorio, Dissanayake, Kosala, Yu, Ly-Mee, Worek, Franz, John, Harald, Smith, Sionagh, Thiermann, Horst, Harris, John B., Eddie Clutton, R.
Publikováno v:
In Toxicology 11 April 2012 294(2-3):94-103
Publikováno v:
Frontiers in Veterinary Science, Vol 3 (2016)
There is a moral obligation to minimize pain in pigs used for human benefit. In livestock production pigs experience pain caused by management procedures, e.g. castration, and tail docking, injuries from fighting or poor housing conditions, managemen
Externí odkaz:
https://doaj.org/article/e649f03c53b247928039fbc6bd0d8bb7
Publikováno v:
Laboratory Animals
Gregson, R, Greenhalgh, S, Cox, B, Cochrane, S & Clutton, E 2020, ' Feeding management before gastrointestinal studies in pigs ', Laboratory Animals . https://doi.org/10.1177/0023677220960509
Gregson, R, Greenhalgh, S, Cox, B, Cochrane, S & Clutton, E 2020, ' Feeding management before gastrointestinal studies in pigs ', Laboratory Animals . https://doi.org/10.1177/0023677220960509
Pigs are used to model humans in gastrointestinal (GI) studies because of their comparable size, physiology and behaviour: both are monogastric omnivores. A porcine surgical model for testing novel, tethered ultrasound capsule endoscopes (USCE) requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed50490a7879e6195896e768e08114bf
https://doi.org/10.1177/0023677220960509
https://doi.org/10.1177/0023677220960509