Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Eddie C.-K. Liu"'
Autor:
David S. Taylor, Lei Zhao, Leonard P. Adam, David A. Gordon, Michael Basso, Alice Ye Chen, Eddie C.-K. Liu, Ji Jiang, Christian Caporuscio, Zulan Pi, James A. Johnson, Soong-Hoon Kim, Heather Finlay, John Lloyd, Joelle M. Onorato, Gregory A. Locke, George O. Tora, Ruth R. Wexler, Todd Kirshgessner, Lynn M. Abell, Xiaohong Yin, Hao Lu, Richard Yang, Sarah C. Traeger, Monique Phillips, Kamelia Behnia, Carol S. Ryan
Publikováno v:
Journal of medicinal chemistry. 63(4)
Endothelial lipase (EL) hydrolyzes phospholipids in high-density lipoprotein (HDL) resulting in reduction in plasma HDL levels. Studies with murine transgenic, KO, or loss-of-function variants strongly suggest that inhibition of EL will lead to susta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac63d0f0187919bbe4a9cac88560ae41
https://pubmed.ncbi.nlm.nih.gov/31990537
https://pubmed.ncbi.nlm.nih.gov/31990537
Autor:
Lynn M. Abell, Brandon Parkhurst, Lei Zhao, Richard Yang, David A. Gordon, Jennifer X. Qiao, Soong-Hoon Kim, Xue-Qing Chen, Joelle M. Onorato, David S. Taylor, Hao Lu, Michael Basso, Alice Ye Chen, Kamelia Behnia, Heather Finlay, Xiaohong Yin, Leonard P. Adam, Ji Jiang, Gregory A. Locke, George O. Tora, Zulan Pi, Monique Phillips, Christian Caporuscio, Ruth R. Wexler, Eddie C.-K. Liu, James A. Johnson
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(15)
A low level of high density lipoprotein (HDL) is an independent risk factor for cardiovascular disease. HDL reduces inflammation and plays a central role in reverse cholesterol transport, where cholesterol is removed from peripheral tissues and ather
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bb80bb08fc94d5bc6f7fade64d10c3
https://pubmed.ncbi.nlm.nih.gov/31353296
https://pubmed.ncbi.nlm.nih.gov/31353296
Autor:
Eddie C.-K. Liu, James A. Johnson, Lynn M. Abell, Leonard P. Adam, Xue-Qing Chen, Christian Caporuscio, Heather Finlay, Jennifer X. Qiao, Brandon Parkhurst, David S. Taylor, Monique Phillips, Soong-Hoon Kim, Ji Jiang, Joelle M. Onorato, Gregory A. Locke, David A. Gordon, Michael Basso, Alice Ye Chen, George O. Tora, Xiaohong Yin, Ruth R. Wexler, Zulan Pi, Richard Yang, Kamelia Behnia, Lei Zhao, Hao Lu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2525
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9051398c276805e08d7346ea27e17323
https://doi.org/10.1016/j.bmcl.2019.07.032
https://doi.org/10.1016/j.bmcl.2019.07.032
Autor:
Zheming Ruan, S. M. Seiler, Herbert E. Klei, Jing Zhang, Jeffrey A. Robl, Stephen P. O'connor, Mengxiao Shi, Liang Schweizer, John E. Macor, R. Michael Lawrence, Karnail S. Atwal, William A. Schumacher, Eddie C.-K. Liu, Sharon N. Bisaha, Doree F. Sitkoff, Ying Wang, Chi Li, Thomas E. Steinbacher, Yan Shi, Philip D. Stein, Kevin Kish
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7516-7521
The design, synthesis and SAR of a novel class of valerolactam-based arylsulfonamides as potent and selective FXa inhibitors is reported. The arylsulfonamide-valerolactam scaffold was derived based on the proposed bioisosterism to the arylcyanoguanid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bb84aabdb3a646b55d279059af6aab
https://doi.org/10.1016/j.bmcl.2011.06.098
https://doi.org/10.1016/j.bmcl.2011.06.098
Autor:
Joseph Yanchunas, Eddie C.-K. Liu, Christine Huang, S. M. Seiler, Yan Shi, Ying Wang, Karnail S. Atwal, Thomas E. Steinbacher, Doree F. Sitkoff, Andrew T. Pudzianowski, William A. Schumacher, Karen S. Hartl, Sharon N. Bisaha, Chi Li, Stephen P. O'connor, Kevin Kish, Mengxiao Shi, Philip D. Stein, Herbert E. Klei, Jing Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6882-6889
We report the design and synthesis of a novel class of N,N'-disubstituted aroylguanidine-based lactam derivatives as potent and orally active FXa inhibitors. The structure-activity relationships (SAR) investigation led to the discovery of the nicotin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f30912ce064e83f0929d53206bf34b3
https://doi.org/10.1016/j.bmcl.2009.10.084
https://doi.org/10.1016/j.bmcl.2009.10.084
Autor:
David M. Floyd, John T. Hunt, Eddie C.-K. Liu, Sesha Natarajan, Anders Hedberg, Stephen M. Festin
Publikováno v:
International Journal of Peptide and Protein Research. 40:567-574
We have developed an expeditious method for the incorporation of the biotinylaminocaproyl moiety on the epsilon-amino group of a lysine residue within a peptide chain in a site-specific manner. Using t-Boc chemistry for the solid phase synthesis appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37d87bfc94b0d24f34fa751995efaf09
https://doi.org/10.1111/j.1399-3011.1992.tb00442.x
https://doi.org/10.1111/j.1399-3011.1992.tb00442.x
Autor:
John T. Hunt, Suzanne Moreland, Maria L. Webb, Diane M. McMullen, Mark S. Bolgar, Ving G. Lee, Eddie C.-K. Liu
Publikováno v:
International Journal of Peptide and Protein Research. 42:249-258
While incorporation of penicillamine residues (Pen; beta,beta-dimethyl cysteine) into a peptide can cause dramatic changes in biological activity, the tendency of Pen to form mixed disulfides should also allow the exploitation of the steric bulk of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d49487cd6c470cf58e6fdf4d712be9
https://doi.org/10.1111/j.1399-3011.1993.tb00139.x
https://doi.org/10.1111/j.1399-3011.1993.tb00139.x
Autor:
Wei Han, Patrick Y.S. Lam, Philip D. Stein, John E. Macor, Jing Zhang, Robert Zahler, Eddie C.-K. Liu, Karnail S. Atwal, Yan Shi, Ying Wang, Saleem Ahmad, Lawrence J. Kennedy, Stephen P. O'connor, S. M. Seiler, Jeffrey A. Robl, Zilun Hu, Doree F. Sitkoff
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5952-5958
The design and synthesis of a novel class of amino(methyl) pyrrolidine-based sulfonamides as potent and selective FXa inhibitors is reported. The amino(methyl) pyrrolidine scaffolds were designed based on the proposed bioisosterism to the piperazine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b9e6828f23d93787599d46256af2d5
https://doi.org/10.1016/j.bmcl.2007.07.063
https://doi.org/10.1016/j.bmcl.2007.07.063
Autor:
Eddie C.-K. Liu, Martin L. Ogletree, William A. Schumacher, Steven E. Seiler, Anne B. Stewart, Jeffrey S. Bostwick, Karen S. Hartl, Thomas E. Steinbacher
Publikováno v:
European Journal of Pharmacology. 570:167-174
The effect of inhibiting activated blood coagulation factor XIa was determined in rat models of thrombosis and hemostasis. BMS-262084 is an irreversible and selective small molecule inhibitor of factor XIa with an IC(50) of 2.8 nM against human facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2011033d840c74b384f998d5cab4be50
https://doi.org/10.1016/j.ejphar.2007.05.043
https://doi.org/10.1016/j.ejphar.2007.05.043
Autor:
Jack Z. Gougoutas, Karen S. Hartl, R. Michael Lawrence, Doree F. Sitkoff, Gregory S. Bisacchi, Steven M. Seiler, Andrew T. Pudzianowski, William A. Schumacher, Philip D. Stein, Eddie C.-K. Liu, Thomas E. Steinbacher, Zhaoxiao Zhang, James C. Sutton
Publikováno v:
Letters in Drug Design & Discovery. 2:625-630
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7cee05c3fc0caebfd7b297901137ea0
https://doi.org/10.2174/157018005774717316
https://doi.org/10.2174/157018005774717316