Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Eddie, Loh"'
Autor:
Kathleen Tsung, Kristie Q Liu, Jane S Han, Krutika Deshpande, Tammy Doan, Yong-Hwee Eddie Loh, Li Ding, Wentao Yang, Josh Neman, Yali Dou, Frank J Attenello
Publikováno v:
PLoS Genetics, Vol 20, Iss 6, p e1011314 (2024)
IntroductionGlioblastoma (GBM) invasion studies have focused on coding genes, while few studies evaluate long non-coding RNAs (lncRNAs), transcripts without protein-coding potential, for role in GBM invasion. We leveraged CRISPR-interference (CRISPRi
Externí odkaz:
https://doaj.org/article/2201916849cd4e9d9a376d0ee0090ca3
Autor:
Helou, Doumet Georges, Quach, Christine, Fung, Marshall, Painter, Jacob D., Hurrell, Benjamin P., Eddie Loh, Yong-Hwee, Howard, Emily, Shafiei-Jahani, Pedram, Soroosh, Pejman, Sharpe, Arlene H., Akbari, Omid
Publikováno v:
In The Journal of Allergy and Clinical Immunology February 2023 151(2):526-538
Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions
Autor:
Sandhya Chandrasekaran, Sergio Espeso-Gil, Yong-Hwee Eddie Loh, Behnam Javidfar, Bibi Kassim, Yueyan Zhu, Yuan Zhang, Yuhao Dong, Lucy K. Bicks, Haixin Li, Prashanth Rajarajan, Cyril J. Peter, Daijing Sun, Esperanza Agullo-Pascual, Marina Iskhakova, Molly Estill, Bluma J. Lesch, Li Shen, Yan Jiang, Schahram Akbarian
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Repeat-rich sequences play a role in 3D genome architecture in higher eukaryotes; however, this remains unexplored in brain cells. Here, the authors show that upregulation of endogenous retroviral (ERV) sequences is linked to changes in the 3D struct
Externí odkaz:
https://doaj.org/article/07892eb57c2e48d7ba5aa0eeb9ce6966
Autor:
Feng Gao, Changgong Li, Susan M Smith, Neil Peinado, Golenaz Kohbodi, Evelyn Tran, Yong-Hwee Eddie Loh, Wei Li, Zea Borok, Parviz Minoo
Publikováno v:
eLife, Vol 11 (2022)
Lung development is precisely controlled by underlying gene regulatory networks (GRN). Disruption of genes in the network can interrupt normal development and cause diseases such as bronchopulmonary dysplasia (BPD) – a chronic lung disease in prete
Externí odkaz:
https://doaj.org/article/a0892f126aa541e9893871d7c3283441
Autor:
Pedram Shafiei-Jahani, Doumet Georges Helou, Benjamin P. Hurrell, Emily Howard, Christine Quach, Jacob D. Painter, Lauriane Galle-Treger, Meng Li, Yong-Hwee Eddie Loh, Omid Akbari
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The role of the CD200–CD200R axis in regulating pulmonary inflammation is not completely understood. Here the authors show CD200R is expressed on type 2 innate lymphoid cells (ILC2s), and its engagement by CD200 ameliorates airway hyperreactivity a
Externí odkaz:
https://doaj.org/article/fea260e6f82a47a287a0d596f7eecfe6
Autor:
Darvishi, Emad, Slemmons, Katherine, Wan, Zesheng, Mitra, Sheetal, Hou, Xiaogang, Hugues Parmentier, Jean, Eddie Loh, Yong-Hwee, Helman, Lee J.
Publikováno v:
In Neoplasia July 2020 22(7):274-282
Autor:
Emad Darvishi, Katherine Slemmons, Zesheng Wan, Sheetal Mitra, Xiaogang Hou, Jean Hugues Parmentier, Yong-Hwee Eddie Loh, Lee J. Helman
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 7, Pp 274-282 (2020)
Fibroblast growth factor receptor 4 (FGFR4) aberrant expression and activity have been linked to the pathogenesis of a variety of cancers including rhabdomyosarcomas (RMS). We found that treatment of alveolar rhabdomyosarcoma (aRMS) cells with Guadec
Externí odkaz:
https://doaj.org/article/e8a5345bdc5d48c5b2b326717e165c49
Autor:
Yongsheng Ruan, Hye Na Kim, Heather A. Ogana, Zesheng Wan, Samantha Hurwitz, Cydney Nichols, Nour Abdel-Azim, Ariana Coba, Seyoung Seo, Yong-Hwee Eddie Loh, Eun Ji Gang, Hisham Abdel-Azim, Chih-Lin Hsieh, Michael R. Lieber, Chintan Parekh, Dhananjaya Pal, Deepa Bhojwani, Donald L. Durden, Yong-Mi Kim
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The PI3K/Akt pathway—and in particular PI3Kδ—is known for its role in drug resistant B-cell acute lymphoblastic leukemia (B-ALL) and it is often upregulated in refractory or relapsed B-ALL. Myc proteins are transcription factors responsible for
Externí odkaz:
https://doaj.org/article/9d2a16f695cc4722b8574521dd391e56
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109387- (2021)
Summary: Analysis of translocation breakpoints in human B cell malignancies reveals that DNA double-strand breaks at oncogenes most frequently occur at CpG sites located within 20–600 bp fragile zones and depend on activation-induced deaminase (AID
Externí odkaz:
https://doaj.org/article/36bc2879a10947e3906294f6c965ccfa
Autor:
Brittany Rocque, Arianna Barbetta, Pranay Singh, Cameron Goldbeck, Doumet Georges Helou, Yong-Hwee Eddie Loh, Nolan Ung, Jerry Lee, Omid Akbari, Juliet Emamaullee
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The liver is unique in both its ability to maintain immune homeostasis and in its potential for immune tolerance following solid organ transplantation. Single-cell RNA sequencing (scRNA seq) is a powerful approach to generate highly dimensional trans
Externí odkaz:
https://doaj.org/article/fefaa1f7820a4208a68318437d9f13d3