Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Edda Thies"'
Autor:
Kira V. Gromova, Edda Thies, Philipp C. Janiesch, Felix P. Lützenkirchen, Yipeng Zhu, Daniele Stajano, Céline D. Dürst, Michaela Schweizer, Anja Konietzny, Marina Mikhaylova, Christine E. Gee, Matthias Kneussel
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112743- (2023)
Summary: Homeostatic synaptic plasticity adjusts the strength of synapses to restrain neuronal activity within a physiological range. Postsynaptic guanylate kinase-associated protein (GKAP) controls the bidirectional synaptic scaling of AMPA receptor
Externí odkaz:
https://doaj.org/article/b4ea89a9a8004deeb934439ce397a69b
Autor:
Mary Muhia, PingAn YuanXiang, Jan Sedlacik, Jürgen R. Schwarz, Frank F. Heisler, Kira V. Gromova, Edda Thies, Petra Breiden, Yvonne Pechmann, Michael R. Kreutz, Matthias Kneussel
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
A murine muskelin knockout induces increased exploratory drive and alters cognition and functional connectivity. These effects correlate with actin-dependent changes in dendritic branching, spine structure, and AMPAR-mediated synaptic transmission.
Externí odkaz:
https://doaj.org/article/2a57e15d62354e63a3239b6cceda15bf
Autor:
Susanne Krasemann, Carsten Dittmayer, Saskia von Stillfried, Jenny Meinhardt, Fabian Heinrich, Kristin Hartmann, Susanne Pfefferle, Edda Thies, Regina von Manitius, Tom Alex David Aschman, Josefine Radke, Anja Osterloh, Simone Schmid, Eva Miriam Buhl, Jana Ihlow, Frank Dubois, Viktor Arnhold, Sefer Elezkurtaj, David Horst, Andreas Hocke, Sara Timm, Sebastian Bachmann, Victor Corman, Hans-Hilmar Goebel, Jakob Matschke, Stephanie Stanelle-Bertram, Gülsah Gabriel, Danielle Seilhean, Homa Adle-Biassette, Benjamin Ondruschka, Matthias Ochs, Werner Stenzel, Frank L. Heppner, Peter Boor, Helena Radbruch, Michael Laue, Markus Glatzel
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104193- (2022)
Summary: Background: Autopsy studies have provided valuable insights into the pathophysiology of COVID-19. Controversies remain about whether the clinical presentation is due to direct organ damage by SARS-CoV-2 or secondary effects, such as overshoo
Externí odkaz:
https://doaj.org/article/8c3f588c9dc544439b18fd7f7d5e9f6b
Autor:
Yue Wang, Kristin Hartmann, Edda Thies, Behnam Mohammadi, Hermann Altmeppen, Diego Sepulveda-Falla, Markus Glatzel, Susanne Krasemann
Publikováno v:
Cells, Vol 11, Iss 19, p 2948 (2022)
Prion diseases are neurodegenerative diseases that affect humans and animals. They are always fatal and, to date, no treatment exists. The hallmark of prion disease pathophysiology is the misfolding of an endogenous protein, the cellular prion protei
Externí odkaz:
https://doaj.org/article/419b6025cb1f4ed49b15a237a4d4f443
Autor:
André T Lopes, Torben J Hausrat, Frank F Heisler, Kira V Gromova, Franco L Lombino, Timo Fischer, Laura Ruschkies, Petra Breiden, Edda Thies, Irm Hermans-Borgmeyer, Michaela Schweizer, Jürgen R Schwarz, Christian Lohr, Matthias Kneussel
Publikováno v:
PLoS Biology, Vol 18, Iss 8, p e3000820 (2020)
Mutations in the gene encoding the microtubule-severing protein spastin (spastic paraplegia 4 [SPG4]) cause hereditary spastic paraplegia (HSP), associated with neurodegeneration, spasticity, and motor impairment. Complicated forms (complicated HSP [
Externí odkaz:
https://doaj.org/article/fd94a10cc9314b0d9d95e7c1e309a73e
Autor:
Kira V. Gromova, Mary Muhia, Nicola Rothammer, Christine E. Gee, Edda Thies, Irina Schaefer, Sabrina Kress, Manfred W. Kilimann, Olga Shevchuk, Thomas G. Oertner, Matthias Kneussel
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2705-2717 (2018)
Autism spectrum disorders (ASDs) are associated with mutations affecting synaptic components, including GluN2B-NMDA receptors (NMDARs) and neurobeachin (NBEA). NBEA participates in biosynthetic pathways to regulate synapse receptor targeting, synapti
Externí odkaz:
https://doaj.org/article/ca348ec380c54b27b6fa8ba02855ace0
Autor:
Mary Muhia, Edda Thies, Dorthe Labonté, Amy E. Ghiretti, Kira V. Gromova, Francesca Xompero, Corinna Lappe-Siefke, Irm Hermans-Borgmeyer, Dietmar Kuhl, Michaela Schweizer, Ora Ohana, Jürgen R. Schwarz, Erika L.F. Holzbaur, Matthias Kneussel
Publikováno v:
Cell Reports, Vol 15, Iss 5, Pp 968-977 (2016)
The kinesin KIF21B is implicated in several human neurological disorders, including delayed cognitive development, yet it remains unclear how KIF21B dysfunction may contribute to pathology. One limitation is that relatively little is known about KIF2
Externí odkaz:
https://doaj.org/article/fe8a1afb790842fab33b17605daed690
Autor:
Dorthe Labonté, Edda Thies, Yvonne Pechmann, Alexander J Groffen, Matthijs Verhage, August B Smit, Ronald E van Kesteren, Matthias Kneussel
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75603 (2013)
Kinesin superfamily proteins (KIFs) are molecular motors that transport cellular cargo along the microtubule cytoskeleton. KIF21B is a neuronal kinesin that is highly enriched in dendrites. The regulation and specificity of microtubule transport invo
Externí odkaz:
https://doaj.org/article/95750b96611b41399b6c6d7cefd83f91
Autor:
Susanne Krasemann, Undine Haferkamp, Susanne Pfefferle, Marcel S. Woo, Fabian Heinrich, Michaela Schweizer, Antje Appelt-Menzel, Alevtina Cubukova, Janica Barenberg, Jennifer Leu, Kristin Hartmann, Edda Thies, Jessica Lisa Littau, Diego Sepulveda-Falla, Liang Zhang, Kathy Ton, Yan Liang, Jakob Matschke, Franz Ricklefs, Thomas Sauvigny, Jan Sperhake, Antonia Fitzek, Anna Gerhartl, Andreas Brachner, Nina Geiger, Eva-Maria König, Jochen Bodem, Sören Franzenburg, Andre Franke, Stefan Moese, Franz-Josef Müller, Gerd Geisslinger, Carsten Claussen, Aimo Kannt, Andrea Zaliani, Philip Gribbon, Benjamin Ondruschka, Winfried Neuhaus, Manuel A. Friese, Markus Glatzel, Ole Pless
Publikováno v:
Stem Cell Reports
Neurological complications are common in COVID-19. Although SARS-CoV-2 has been detected in patients’ brain tissues, its entry routes and resulting consequences are not well understood. Here, we show a pronounced upregulation of interferon signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68e22383ffac1460e83740e8cc223e1
https://doi.org/10.1016/j.stemcr.2021.12.011
https://doi.org/10.1016/j.stemcr.2021.12.011
Autor:
Kira V. Gromova, Edda Thies, Céline D. Dürst, Daniele Stajano, Michaela Schweizer, Marina Mikhaylova, Christine E. Gee, Matthias Kneussel
Homeostatic synaptic plasticity adjusts the strength of synapses to restrain neuronal activity within a physiological range. Postsynaptic GKAP controls the bidirectional synaptic scaling of AMPA receptors (AMPARs) however how chronic activity trigger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fceaf787e6876dad89cf53db51772c8d
https://doi.org/10.1101/2022.05.04.490582
https://doi.org/10.1101/2022.05.04.490582
