Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Edcon, Chang"'
Autor:
Han Wee Ong, Xuan Yang, Jeffery L. Smith, Sharon Taft-Benz, Stefanie Howell, Rebekah J. Dickmander, Tammy M. Havener, Marcia K. Sanders, Jason W. Brown, Rafael M. Couñago, Edcon Chang, Andreas Krämer, Nathaniel J. Moorman, Mark Heise, Alison D. Axtman, David H. Drewry, Timothy M. Willson
Publikováno v:
Molecules, Vol 29, Iss 17, p 4158 (2024)
The host kinase casein kinase 2 (CSNK2) has been proposed to be an antiviral target against β-coronaviral infection. To pharmacologically validate CSNK2 as a drug target in vivo, potent and selective CSNK2 inhibitors with good pharmacokinetic proper
Externí odkaz:
https://doaj.org/article/62c77468b14449aaab38290f68c9e3ba
Autor:
Xuan Yang, Han Wee Ong, Rebekah J. Dickmander, Jeffery L. Smith, Jason W. Brown, William Tao, Edcon Chang, Nathaniel J. Moorman, Alison D. Axtman, Timothy M. Willson
Publikováno v:
ACS Omega, Vol 8, Iss 42, Pp 39546-39561 (2023)
Externí odkaz:
https://doaj.org/article/4d7b606ed5844499b2833820f6af20b2
Autor:
Xuan Yang, Rebekah J. Dickmander, Armin Bayati, Sharon A. Taft-Benz, Jeffery L. Smith, Carrow I. Wells, Emily A. Madden, Jason W. Brown, Erik M. Lenarcic, Boyd L. Yount, Edcon Chang, Alison D. Axtman, Ralph S. Baric, Mark T. Heise, Peter S. McPherson, Nathaniel J. Moorman, Timothy M. Willson
Publikováno v:
bioRxiv : the preprint server for biology.
Inhibition of the protein kinase CSNK2 with any of 30 specific and selective inhibitors representing different chemotypes, blocked replication of pathogenic human and murine β-coronaviruses. The potency of in-cell CSNK2A target engagement across the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bd622de1b2d4f231e2e25fae832788
https://pubmed.ncbi.nlm.nih.gov/35723434
https://pubmed.ncbi.nlm.nih.gov/35723434
Autor:
Xuan Yang, Rebekah J. Dickmander, Armin Bayati, Sharon A. Taft-Benz, Jeffery L. Smith, Carrow I. Wells, Emily A. Madden, Jason W. Brown, Erik M. Lenarcic, Boyd L. Yount, Edcon Chang, Alison D. Axtman, Ralph S. Baric, Mark T. Heise, Peter S. McPherson, Nathaniel J. Moorman, Timothy M. Willson
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 3
article-version (status) pre
article-version (number) 3
Inhibition of the protein kinase CSNK2 with any of 30 specific and selective inhibitors representing different chemotypes, blocked replication of pathogenic human and murine β-coronaviruses. The potency of in-cell CSNK2A target engagement across the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc35b8d18d3437b057697dea428a8e3
Autor:
Keith A. Koch, Michael B. Cable, Todd A. Black, Edcon Chang, Scott S. Walker, Yan Hou, Michelle Fornarotto, Robert M. O'Malley, Li Xiao
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1761:52-63
An early step in sphingolipid biosynthesis, the reduction of 3-ketosphinganine, is catalyzed in the yeast Saccharomyces cerevisiae by Tsc10p (TSC10 (YBR265W)). We have identified orthologs of TSC10 in two clinically important fungal pathogens, Candid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad39570efecc3b04241ef6677aa8ebc
https://doi.org/10.1016/j.bbalip.2005.11.013
https://doi.org/10.1016/j.bbalip.2005.11.013
Autor:
Fabrice Pierre, Lin Yu, Daniel S. Sem, Hugo O. Villar, Mark R. Hansen, Victor Hong, Richard Kho, Stephen M. Coutts, Henk Lang, Qing Dong, Edcon Chang, Xuemei Huang, Aurora D. Costache, Maurizio Pellecchia, David Meininger, Richard M. Jack, Chen-Ting Ma, Bonnie L. Bertolaet, Brian Baker
Publikováno v:
Chemistry & Biology. 11:185-194
Genomics-driven growth in the number of enzymes of unknown function has created a need for better strategies to characterize them. Since enzyme inhibitors have traditionally served this purpose, we present here an efficient systems-based inhibitor de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0b98c770547120dc17a27cefd71d5b
https://doi.org/10.1016/j.chembiol.2004.02.012
https://doi.org/10.1016/j.chembiol.2004.02.012
Publikováno v:
Journal of Biomolecular NMR. 22:165-173
Genomic research on target identification and validation has created a great need for methods that rapidly provide detailed structural information on protein-ligand interactions. We developed a suite of NMR experiments as rapid and efficient tools to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a593727e1d9e48c0d716a572a3ea5639
https://doi.org/10.1023/a:1014256707875
https://doi.org/10.1023/a:1014256707875
Autor:
Daniel S, Sem, Bonnie, Bertolaet, Brian, Baker, Edcon, Chang, Aurora D, Costache, Stephen, Coutts, Qing, Dong, Mark, Hansen, Victor, Hong, Xuemei, Huang, Richard M, Jack, Richard, Kho, Henk, Lang, Chen-Ting, Ma, David, Meininger, Maurizio, Pellecchia, Fabrice, Pierre, Hugo, Villar, Lin, Yu
Publikováno v:
Chemistrybiology. 11(2)
Genomics-driven growth in the number of enzymes of unknown function has created a need for better strategies to characterize them. Since enzyme inhibitors have traditionally served this purpose, we present here an efficient systems-based inhibitor de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c605f35fbea1b7c1afc61da144168dc9
https://pubmed.ncbi.nlm.nih.gov/15123257
https://pubmed.ncbi.nlm.nih.gov/15123257
Publikováno v:
Journal of biomolecular NMR. 22(2)
Genomic research on target identification and validation has created a great need for methods that rapidly provide detailed structural information on protein-ligand interactions. We developed a suite of NMR experiments as rapid and efficient tools to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::985e2e0e182c830fa1ef76df925f0600
https://pubmed.ncbi.nlm.nih.gov/11883777
https://pubmed.ncbi.nlm.nih.gov/11883777
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 49:1401-1402
The indan-1,3-dione system is slightly non-planar, with the tetrahedral C atom lying 0.149 (2) A out of the best plane of the other eight C and two O atoms. The terminal C atom of the ethyl group is directed anti to the nitro group and gauche to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ede3be07e6da3aa66012b108d73549f3
https://doi.org/10.1107/s0108270193000976
https://doi.org/10.1107/s0108270193000976