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Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs.

Autor: Kamola PJ; Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK; GlaxoSmithKline R&D, Ware SG12 0DP, UK; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Harwell Science and Innovation Campus, Oxfordshire OX11 0RQ, UK. Electronic address: piotr.kamola@riken.jp., Maratou K; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Wilson PA; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Rush K; GlaxoSmithKline R&D, Ware SG12 0DP, UK., Mullaney T; GlaxoSmithKline R&D, Ware SG12 0DP, UK., McKevitt T; GlaxoSmithKline R&D, Ware SG12 0DP, UK., Evans P; GlaxoSmithKline R&D, Ware SG12 0DP, UK., Ridings J; GlaxoSmithKline R&D, Ware SG12 0DP, UK., Chowdhury P; GlaxoSmithKline R&D, Ware SG12 0DP, UK., Roulois A; GlaxoSmithKline R&D, Ware SG12 0DP, UK., Fairchild A; GlaxoSmithKline R&D, Ware SG12 0DP, UK., McCawley S; GlaxoSmithKline R&D, Ware SG12 0DP, UK., Cartwright K; GlaxoSmithKline R&D, Ware SG12 0DP, UK., Gooderham NJ; Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK., Gant TW; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Harwell Science and Innovation Campus, Oxfordshire OX11 0RQ, UK., Moores K; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Hughes SA; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Edbrooke MR; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Clark K; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Parry JD; GlaxoSmithKline R&D, Ware SG12 0DP, UK.

Publikováno v: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2017 Sep 15; Vol. 8, pp. 383-394. Date of Electronic Publication: 2017 Jul 08.

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Akademický článek

In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization.

Autor: Kamola PJ; Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK GlaxoSmithKline R&D, Ware SG12 0DP, UK GlaxoSmithKline R&D, Stevenage SG1 2NY, UK Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Harwell Science and Innovation Campus OX11 0RQ, UK piotr.j.kamola@gsk.com., Kitson JD; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Turner G; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Maratou K; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Eriksson S; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Panjwani A; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Warnock LC; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Douillard Guilloux GA; GlaxoSmithKline R&D, Les Ulis 91951, France., Moores K; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Koppe EL; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Wixted WE; GlaxoSmithKline R&D, Upper Merion 19406, US., Wilson PA; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Gooderham NJ; Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK., Gant TW; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Harwell Science and Innovation Campus OX11 0RQ, UK., Clark KL; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Hughes SA; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Edbrooke MR; GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Parry JD; GlaxoSmithKline R&D, Ware SG12 0DP, UK.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2015 Oct 15; Vol. 43 (18), pp. 8638-50. Date of Electronic Publication: 2015 Sep 03.

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Akademický článek

Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis.

Autor: Clark KL; Therapeutic Oligonucleotide Discovery Performance Unit, Respiratory Therapeutic Area Unit, Computational Biology & PTS, GlaxoSmithKline (GSK)., Hughes SA, Bulsara P, Coates J, Moores K, Parry J, Carr M, Mayer RJ, Wilson P, Gruenloh C, Levin D, Darton J, Weber WM, Sobczak K, Gill DR, Hyde SC, Davies LA, Pringle IA, Sumner-Jones SG, Jadhav V, Jamison S, Strapps WR, Pickering V, Edbrooke MR

Publikováno v: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2013 Jan 15; Vol. 2, pp. e65. Date of Electronic Publication: 2013 Jan 15.

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Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-κB and EGFR pathways.

Autor: Hewson CA; Dept of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London, W2 1PG, UK., Haas JJ, Bartlett NW, Message SD, Laza-Stanca V, Kebadze T, Caramori G, Zhu J, Edbrooke MR, Stanciu LA, Kon OM, Papi A, Jeffery PK, Edwards MR, Johnston SL

Publikováno v: The European respiratory journal [Eur Respir J] 2010 Dec; Vol. 36 (6), pp. 1425-35. Date of Electronic Publication: 2010 Jun 04.

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Akademický článek

Acceptor specificity of the human leukocyte alpha3 fucosyltransferase: role of FucT-VII in the generation of selectin ligands.

Autor: Britten CJ; Glycobiology Research Unit, GlaxoWellcome Research and Development Ltd., Medicines Research Centre, Stevenage, Herts, SG1 2NY, UK., van den Eijnden DH, McDowell W, Kelly VA, Witham SJ, Edbrooke MR, Bird MI, de Vries T, Smithers N

Publikováno v: Glycobiology [Glycobiology] 1998 Apr; Vol. 8 (4), pp. 321-7.

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Akademický článek

Lewis X biosynthesis in Helicobacter pylori. Molecular cloning of an alpha(1,3)-fucosyltransferase gene.

Autor: Martin SL; Glycobiology Unit, GlaxoWellcome Medicines Research Centre, Stevenage, Herts SG1 2NY, United Kingdom. slm17885@ggr.co.uk, Edbrooke MR, Hodgman TC, van den Eijnden DH, Bird MI

Publikováno v: The Journal of biological chemistry [J Biol Chem] 1997 Aug 22; Vol. 272 (34), pp. 21349-56.

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Akademický článek

The alpha(1-3)-fucosyltransferases come of age.

Autor: Edbrooke MR; Glycobiology Unit, GlaxoWellcome Research and Development, Stevenage, U.K., Britten CJ, Kelly VA, Martin SL, Smithers N, Winder AJ, Witham SJ, Bird MI

Publikováno v: Biochemical Society transactions [Biochem Soc Trans] 1997 Aug; Vol. 25 (3), pp. 880-6.

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Akademický článek

Expression of a secreted form of human alpha 1,3 fucosyltransferase VII from insect cells.

Autor: Smithers N; Glycobiology Unit, Glaxo Wellcome Research and Development, Medicines Research Centre, Herts, U.K., Kelly VA, Witham SJ, Edbrooke MR, Britten CJ

Publikováno v: Biochemical Society transactions [Biochem Soc Trans] 1997 Aug; Vol. 25 (3), pp. 426S.

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