Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Edbert D Lu"'
Autor:
Hideho Okada, Lawrence Fong, Christine E Brown, Shilpa A Shahani, Paul R Walker, Meenal Sinha, Eric V Liu, Erin F Simonds, Edbert D Lu, Oscar Badillo, Shokoufeh Karimi, Whitney Tamaki, Chiara Rancan, Kira M Downey, Jacob Stultz, Lauren K McHenry, Nicole M Nasholm, Pavlina Chuntova, Anders Sundström, Vassilis Genoud, Leo D Wang, Fredrik J Swartling, William A Weiss, Mats Hellström
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Glioblastoma (GBM) is refractory to immune checkpoint inhibitor (ICI) therapy. We sought to determine to what extent this immune evasion is due to intrinsic properties of the tumor cells versus the specialized immune context of the brain,
Externí odkaz:
https://doaj.org/article/6b195c70cb3f48339806e87479adb50b
Publikováno v:
J Biol Chem
Lipoxygenases are widespread enzymes found in virtually all eukaryotes, including fungi, and, more recently, in prokaryotes. These enzymes act on long-chain polyunsaturated fatty acid substrates (C18 to C20), raising questions regarding how the subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3041ec1ae811dc6ff549c7fe3beb5d10
https://doi.org/10.1074/jbc.ra119.010826
https://doi.org/10.1074/jbc.ra119.010826
Autor:
Aimée du Chatinier, Michaël H Meel, Arvid I Das, Dennis S Metselaar, Piotr Waranecki, Marianna Bugiani, Marjolein Breur, Erin F Simonds, Edbert D Lu, William A Weiss, Juan J Garcia Vallejo, Eelco W Hoving, Timothy N Phoenix, Esther Hulleman
Publikováno v:
Neuro-Oncology. 24:i172-i172
Diffuse midline gliomas (DMG) are highly aggressive pediatric brain tumors with a grim prognosis. A lack of effective treatment options highlights the critical need to investigate new therapeutic strategies. This includes the use of immunotherapy, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70efbf11f0d3919297b7aec521184bee
https://doi.org/10.1093/neuonc/noac079.639
https://doi.org/10.1093/neuonc/noac079.639
Autor:
Pavlina Chuntova, William A. Weiss, Chiara Rancan, Meenal Sinha, Erin F. Simonds, Leo D. Wang, Edbert D. Lu, Christine E. Brown, Lauren K. McHenry, Nicole M. Nasholm, Jacob Stultz, Paul R. Walker, Mats Hellström, Whitney Tamaki, Lawrence Fong, Anders Sundström, Hideho Okada, Shilpa A. Shahani, E Liu, Fredrik J. Swartling, Vassilis Genoud
BackgroundGlioblastoma (GBM) is refractory to checkpoint blockade immunotherapy (CPI). We sought to determine to what extent this immune evasion is due to intrinsic properties of the tumor cells versus the specialized immune context of the brain, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c5bda9b67d9e4706d52d535c24cd023
https://doi.org/10.1101/2020.12.01.404939
https://doi.org/10.1101/2020.12.01.404939
Autor:
Lasse Meyer, Stefan Grossauer, Claudia Petritsch, Whitney Tamaki, Wei Wang, Yoko Hirata, Anne Marie Barrette, Edbert D. Lu
Publikováno v:
Neuro Oncol
Pediatric low-grade glioma (pLGG), the most common brain cancer in children, is difficult to treat especially at recurrence. The BRAF V600E mutation is the second most common mutation in pLGG, and in a high-risk group for progression is associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6aa3dc90443c2428ab6b378c2c3876
https://europepmc.org/articles/PMC7651454/
https://europepmc.org/articles/PMC7651454/
Autor:
Xujun Luo, Manasi K. Mayekar, Z. H. An, Franziska Haderk, Albert S. Baldwin, Qi-Wen Fan, Kevan M. Shokat, Edbert D. Lu, Trever G. Bivona, Robyn A. Wong, William A. Weiss
Publikováno v:
Neuro Oncol
Neuro-oncology, vol 22, iss 4
Neuro-oncology, vol 22, iss 4
Background The transcription factor signal transducer and activator of transcription 3 (STAT3) drives progression in glioblastoma (GBM), suggesting STAT3 as a therapeutic target. Surprisingly however, GBM cells generally show primary resistance to ST
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee780cc141b80df9cf9d1bdf149d72f4
https://europepmc.org/articles/PMC7158663/
https://europepmc.org/articles/PMC7158663/
Autor:
William A. Weiss, Pavlina Chuntova, Lauren K. McHenry, Hideho Okada, Erin F. Simonds, Edbert D. Lu, Mats Hellström
The negative phase 3 trial of anti-PD-1 in human glioblastoma (GBM) contradicts preclinical data showing eradication of GL261 mouse brain tumors by checkpoint inhibitors (CPI). To understand whether the tumor microenvironment contributed to this disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b36dab719bafcaa2682d7f92076c8d
https://europepmc.org/articles/PMC6217332/
https://europepmc.org/articles/PMC6217332/
Autor:
Erin F. Simonds, Nicole Nasholm, Lauren K. McHenry, Marie Menard, Shannon Wong-Michalak, William A. Weiss, W. Clay Gustafson, Edbert D. Lu
Publikováno v:
Neuro-Oncology. 21:ii94-ii94
Combining anti-GD2 ganglioside monoclonal antibody with immune-activating cytokines improves survival in high-risk neuroblastoma, a breakthrough for immunotherapy in this disease. However, approaches such as immune checkpoint blockade, anti-GD2 CAR-T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2852d03ea73c83016e9a5664b6a3524a
https://doi.org/10.1093/neuonc/noz036.127
https://doi.org/10.1093/neuonc/noz036.127
Publikováno v:
Approaching China's Pharmaceutical Market ISBN: 9783319155753
The regulatory framework for in vitro diagnostic reagents in China has been undergoing fast and fundamental changes. In addition to the knowledge of the in vitro diagnostic reagent market in China, it is also important for international companies to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4e601fcbbdf5342a20503c9c6e17320
https://doi.org/10.1007/978-3-319-15576-0_10
https://doi.org/10.1007/978-3-319-15576-0_10
Publikováno v:
Approaching China's Pharmaceutical Market ISBN: 9783319155753
Currently, drug registrations in China follow the Provisions for Drug Registration, Order No. 28, effective since 2007. This regulation provides clear definitions and dossier application requirements for various drug categories and classes in the acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08a925fc837ff1c2092fd02b17286773
https://doi.org/10.1007/978-3-319-15576-0_5
https://doi.org/10.1007/978-3-319-15576-0_5