CYP19A1 single nucleotide polymorphism associations with CYP19A1, NFκB1, and IL6 gene expression in human normal colon and normal liver samples

Autor: Penney RB, Lundgreen A, Yao-Borengasser A, Edavana VK, Williams S, Dhakal I, Wolff RK, Kadlubar S, Slattery ML

Publikováno v: Pharmacogenomics and Personalized Medicine, Vol 2014, Iss default, Pp 163-171 (2014)

Rosalind B Penney,1 Abbie Lundgreen,2 Aiwei Yao-Borengasser,3 Vineetha K Edavana,3 Suzanne Williams,3 Ishwori Dhakal,4 Roger K Wolff,2 Susan Kadlubar,3 Martha L Slattery2 1Department of Environmental and Occupational Health, University of Arkansas fo

Externí odkaz: https://doaj.org/article/35847bd4bdda4bd0bd298f34ef9372a7

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A potential role for human UDP-glucuronosyltransferase 1A4 promoter single nucleotide polymorphisms in the pharmacogenomics of tamoxifen and its derivatives.

Autor: Greer AK; Departments of Biochemistry and Molecular Biology (A.K.G., C.R.D., S.M.B., A.R.-P.), Medical Genetics (A.S.-D., V.K.E., S.A.K.), and Biostatistics (I.B.D.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)., Dates CR; Departments of Biochemistry and Molecular Biology (A.K.G., C.R.D., S.M.B., A.R.-P.), Medical Genetics (A.S.-D., V.K.E., S.A.K.), and Biostatistics (I.B.D.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)., Starlard-Davenport A; Departments of Biochemistry and Molecular Biology (A.K.G., C.R.D., S.M.B., A.R.-P.), Medical Genetics (A.S.-D., V.K.E., S.A.K.), and Biostatistics (I.B.D.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)., Edavana VK; Departments of Biochemistry and Molecular Biology (A.K.G., C.R.D., S.M.B., A.R.-P.), Medical Genetics (A.S.-D., V.K.E., S.A.K.), and Biostatistics (I.B.D.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)., Bratton SM; Departments of Biochemistry and Molecular Biology (A.K.G., C.R.D., S.M.B., A.R.-P.), Medical Genetics (A.S.-D., V.K.E., S.A.K.), and Biostatistics (I.B.D.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)., Dhakal IB; Departments of Biochemistry and Molecular Biology (A.K.G., C.R.D., S.M.B., A.R.-P.), Medical Genetics (A.S.-D., V.K.E., S.A.K.), and Biostatistics (I.B.D.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)., Finel M; Departments of Biochemistry and Molecular Biology (A.K.G., C.R.D., S.M.B., A.R.-P.), Medical Genetics (A.S.-D., V.K.E., S.A.K.), and Biostatistics (I.B.D.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)., Kadlubar SA; Departments of Biochemistry and Molecular Biology (A.K.G., C.R.D., S.M.B., A.R.-P.), Medical Genetics (A.S.-D., V.K.E., S.A.K.), and Biostatistics (I.B.D.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)., Radominska-Pandya A; Departments of Biochemistry and Molecular Biology (A.K.G., C.R.D., S.M.B., A.R.-P.), Medical Genetics (A.S.-D., V.K.E., S.A.K.), and Biostatistics (I.B.D.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.) RadominskaAnna@uams.edu.

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2014 Sep; Vol. 42 (9), pp. 1392-400. Date of Electronic Publication: 2014 Jun 10.

Fulvestrant up regulates UGT1A4 and MRPs through ERα and c-Myb pathways: a possible primary drug disposition mechanism.

Autor: Edavana VK; Division of Medical Genetics, College of Medicine, University of Arkansas for Medical Sciences, 4301 W. Markham, #580, Little Rock, AR 72205 USA., Penney RB, Yao-Borengasser A, Williams S, Rogers L, Dhakal IB, Kadlubar S

Publikováno v: SpringerPlus [Springerplus] 2013 Nov 20; Vol. 2, pp. 620. Date of Electronic Publication: 2013 Nov 20 (Print Publication: 2013).