Incomplete dosage compensation in an evolving Drosophila sex chromosome

Autor: Norman Arnheim, Claus Pelling, Ed Strobel

Publikováno v: Proceedings of the National Academy of Sciences. 75:931-935

Cellular autoradiography was used to measure relative rates of chromosomal RNA synthesis and to examine the regulatory phenomenon of X-linked dosage compensation in Drosophila miranda, a species containing two distinct, nonhomologous X chromosomes (X

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca723c7ca82a227c76b8d49545627e0
https://doi.org/10.1073/pnas.75.2.931

A small molecule that targets the processivity factor of molluscum contagiosum virus has therapeutic potential.

Autor: Guan H; Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, USA., Nuth M; Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, USA., Isaacs SN; Perelman School of Medicine, University of Pennsylvania, USA., Xiao Y; Perelman School of Medicine, University of Pennsylvania, USA., Scott RW; Fox Chase Chemical Diversity Center, USA., Parker MH; Fox Chase Chemical Diversity Center, USA., Strobel ED; Fox Chase Chemical Diversity Center, USA., Kulp JL 3rd; Conifer Point Pharmaceuticals, Doylestown, PA, USA., Bailey TR; TR Bailey Consulting LLC, Phoenixville, PA, USA., Reitz AB; Fox Chase Chemical Diversity Center, USA., Ricciardi RP; Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, USA; Abramson Cancer Center, School of Medicine, University of Pennsylvania, USA. Electronic address: ricciard@upenn.edu.

Publikováno v: Antiviral research [Antiviral Res] 2023 Mar; Vol. 211, pp. 105520. Date of Electronic Publication: 2023 Jan 02.

Mutation and structure guided discovery of an antiviral small molecule that mimics an essential C-Terminal tripeptide of the vaccinia D4 processivity factor.

Autor: Nuth M; Department of Microbiology, School of Dental Medicine and the Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Guan H; Department of Microbiology, School of Dental Medicine and the Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Xiao Y; Department of Medicine, Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kulp JL 3rd; Conifer Point Pharmaceuticals, Doylestown, PA, USA., Parker MH; Fox Chase Chemical Diversity Center, Inc., Doylestown, PA, USA., Strobel ED; Fox Chase Chemical Diversity Center, Inc., Doylestown, PA, USA., Isaacs SN; Department of Medicine, Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Scott RW; Fox Chase Chemical Diversity Center, Inc., Doylestown, PA, USA., Reitz AB; Fox Chase Chemical Diversity Center, Inc., Doylestown, PA, USA., Ricciardi RP; Department of Microbiology, School of Dental Medicine and the Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: Ricciard@upenn.edu.

Publikováno v: Antiviral research [Antiviral Res] 2019 Feb; Vol. 162, pp. 178-185. Date of Electronic Publication: 2018 Dec 20.

Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes.

Autor: Goodwin NC; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 110 Allen Road, Basking Ridge, New Jersey 07920, United States., Ding ZM, Harrison BA; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 110 Allen Road, Basking Ridge, New Jersey 07920, United States., Strobel ED; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 110 Allen Road, Basking Ridge, New Jersey 07920, United States., Harris AL, Smith M, Thompson AY, Xiong W, Mseeh F, Bruce DJ, Diaz D, Gopinathan S, Li L, O'Neill E, Thiel M, Wilson AG, Carson KG; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 110 Allen Road, Basking Ridge, New Jersey 07920, United States., Powell DR, Rawlins DB; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 110 Allen Road, Basking Ridge, New Jersey 07920, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Jan 26; Vol. 60 (2), pp. 710-721. Date of Electronic Publication: 2017 Jan 17.

Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads.

Autor: Huang Y; Research and Early Development, Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring House, PA 19477-0776, USA., Strobel ED, Ho CY, Reynolds CH, Conway KA, Piesvaux JA, Brenneman DE, Yohrling GJ, Moore Arnold H, Rosenthal D, Alexander RS, Tounge BA, Mercken M, Vandermeeren M, Parker MH, Reitz AB, Baxter EW

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 May 15; Vol. 20 (10), pp. 3158-60. Date of Electronic Publication: 2010 Mar 30.