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Supplementary Methods and Figures S1 to S7 from CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment

Autor: John H. Healey, Ed Purdue, Toshifumi Ozaki, Toshiyoshi Fujiwara, Malcolm A.S. Moore, Yildirim Dogan, Hiroshi Tazawa, Toshiaki Hata, Hiroya Kondo, Aki Yoshida, Vinagolu K. Rajasekhar, Ouathek Ouerfelli, Guangli Yang, Alexander B. Christ, Andrew Chandler, Mohamed A. Yakoub, Tomohiro Fujiwara

Supplementary data file shows supplementary methods and figures S1 to S7. Supplementary Figure S1 shows the establishment of the in vitro sarcoma TAM model. Supplementary Figure S2 shows the effect of anti-CSF-1 and anti-CSF-1R mAb and pazopanib on i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5189897e5f12d95594cfe86979c125ec
https://doi.org/10.1158/1535-7163.22522852

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CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment

Autor: Andrew Chandler, Alexander B. Christ, Ouathek Ouerfelli, Yildirim Dogan, Malcolm A.S. Moore, Toshiaki Hata, Aki Yoshida, Tomohiro Fujiwara, John H. Healey, Toshifumi Ozaki, Vinagolu K. Rajasekhar, Hiroshi Tazawa, Mohamed A. Yakoub, Toshiyoshi Fujiwara, Guangli Yang, Ed Purdue, Hiroya Kondo

Publikováno v: Mol Cancer Ther

Colony-stimulating factor 1 (CSF1) is a primary regulator of the survival, proliferation, and differentiation of monocyte/macrophage that sustains the protumorigenic functions of tumor-associated macrophages (TAMs). Considering current advances in un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687f2b650a75a9fe0e9f38cd22a0217c
https://doi.org/10.1158/1535-7163.mct-20-0591

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An Alternative Macrophage Activation Pathway Regulator, CHIT1, May Provide a Serum and Synovial Fluid Biomarker of Periprosthetic Osteolysis

Autor: Ed Purdue, Athanos Karamitros, Joseph M. Lane, Jonathan E. Jo, Samir K. Trehan, Lester Zambrana, Joseph T. Nguyen

Publikováno v: HSS Journal

Background Periprosthetic osteolysis (PPO) is a frequent indication for total hip replacement (THR) failure. Currently, PPO diagnosis occurs in advanced stages that often necessitate complex revisions due to bone loss. PPO biomarkers could facilitate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2dd75722a2a36bdf1cd5d478b98242
https://pubmed.ncbi.nlm.nih.gov/29983656

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Are there biological markers for wear or corrosion? A systematic review

Autor: Ed Purdue, Ryan D. Ross, D. Rick Sumner

Publikováno v: Clinical orthopaedics and related research. 472(12)

Identification of biomarkers associated with wear and tribocorrosion in joint arthroplasty would be helpful to enhance early detection of aseptic loosening and/or osteolysis and to improve understanding of disease progression. There have been several

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0688861067fc90189ac3197c8ea695b
https://pubmed.ncbi.nlm.nih.gov/24668073

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