Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ed Manser"'
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163915 (2016)
A nodal cytoplasmic actin network underlies actin cytoplasm cohesion in the absence of stress fibers. We previously described such a network that forms upon Latrunculin A (LatA) treatment, in which formin DAAM1 was localized at these nodes. Knock dow
Externí odkaz:
https://doaj.org/article/91dae01b4b2241608efa05e1bbee3684
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129634 (2015)
The serine/threonine kinase PAK4 is a Cdc42 effector whose role is not well understood; overexpression of PAK4 has been associated with some cancers, and there are reports that correlate kinase level with increased cell migration in vitro. Here we re
Externí odkaz:
https://doaj.org/article/618d8f0ba5314823b452f543b539e6c3
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10125 (2010)
BACKGROUND: In early vertebrate development, embryonic tissues modulate cell adhesiveness and acto-myosin contractility to correctly orchestrate the complex processes of gastrulation. E-cadherin (E-cadh) is the earliest expressed cadherin and is need
Externí odkaz:
https://doaj.org/article/862715c32f8e436cb93ecf2430bd396d
Autor:
Liuh Ling Goh, Ed Manser
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12409 (2010)
BACKGROUND: Rnd3 (RhoE) protein belongs to the unique branch of Rho family GTPases that has low intrinsic GTPase activity and consequently remains constitutively active [1], [2]. The current consensus is that Rnd1 and Rnd3 function as important antag
Externí odkaz:
https://doaj.org/article/a0464c8bb9d2463d9ae35ab2af09ccc9
Autor:
Li-Fong Seet, Roseline Su, V A Barathi, Wing Sum Lee, Rebekah Poh, Yee Meng Heng, Ed Manser, Eranga N Vithana, Tin Aung, Matt Weaver, E Helene Sage, Tina T Wong
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9415 (2010)
Glaucoma is a disease frequently associated with elevated intraocular pressure that can be alleviated by filtration surgery. However, the post-operative subconjunctival scarring response which blocks filtration efficiency is a major hurdle to the ach
Externí odkaz:
https://doaj.org/article/e93f3dfc7c0d46fe9a9bcea67ed39746
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e744 (2010)
BACKGROUND: Disheveled-associated activator of morphogenesis 1 (DAAM1) is a formin acting downstream of Wnt signaling that is important for planar cell polarity. It has been shown to promote proper cell polarization during embryonic development in bo
Externí odkaz:
https://doaj.org/article/ff6abe1d6ad84b93aa9ec707993cfdcf
Autor:
Perry M, Chan, Ed, Manser
Publikováno v:
Progress in molecular biology and translational science. 106
The p21-activated kinases (PAKs) are one of the first direct kinase targets of Ras-related small GTPases to be discovered and have emerged as central players in growth factor signaling networks that regulate morphogenetic processes. In some situation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da9e189ba51123404a283f655c5ec33d
https://pubmed.ncbi.nlm.nih.gov/22340718
https://pubmed.ncbi.nlm.nih.gov/22340718
Publikováno v:
The Journal of biological chemistry. 284(50)
ACK1 (activated Cdc42-associated kinase 1), a cytoplsmic tyrosine kinase, is implicated in metastatic behavior, cell spreading and migration, and epidermal growth factor receptor (EGFR) signaling. The function of ACK1 in the regulation of receptor ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8ab0037fecddea4f64d63be4bc9684c
https://pubmed.ncbi.nlm.nih.gov/19815557
https://pubmed.ncbi.nlm.nih.gov/19815557
Autor:
Yong-Sung Juhnn, Ed Manser, Eung-Gook Kim, Tae Goo Cho, Sukgil Song, Sang Chul Park, Young Gyu Kim, Chan-Soo Lee, Eun-Young Shin
Publikováno v:
The Journal of biological chemistry. 281(47)
Neuritogenesis requires active actin cytoskeleton rearrangement in which Rho GTPases play a pivotal role. In a previous study (Shin, E. Y., Woo, K. N., Lee, C. S., Koo, S. H., Kim, Y. G., Kim, W. J., Bae, C. D., Chang, S. I., and Kim, E. G. (2004) J.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ea6160d1c66f39c7db793b2048dc20
https://pubmed.ncbi.nlm.nih.gov/16954223
https://pubmed.ncbi.nlm.nih.gov/16954223
Autor:
Ed Manser
Publikováno v:
Proteins and Cell Regulation ISBN: 140203461X
Rho-family GTPases (p21s) are molecular switches related to the protooncogene Ras: these function in complementary pathways to orchestrate the actin cytoskeleton, regulate cell polarity, microtubule dynamics, membrane transport pathways and modulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f4357eecf7857278eb8c0a6c39d447d
https://doi.org/10.1007/1-4020-3462-8_1
https://doi.org/10.1007/1-4020-3462-8_1
