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Degradation study of the investigational anticancer drug clanfenur

Autor: C. Sluiter, Auke Bult, Willy J. M. Underberg, Ed Hop, J. J. Kettenes-van den Bosch, O.A.G.J. van der Houwen

Publikováno v: International Journal of Pharmaceutics. 185:227-235

Clanfenur belongs to a new group of substituted benzoylphenylureas. The drug shows both in vitro and in vivo antitumour activity. To assess its chemical stability, a study was carried out in which the effect of pH, temperature, ionic strength and buf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4e5d24e1b1ecb027ed81d3f81825bc
https://doi.org/10.1016/s0378-5173(99)00160-x

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Qualitative and quantitative aspects of the degradation of several tripeptides derived from the antitumour peptide antagonist [Arg6, D-Trp7,9, MePhe8] substance P{6–11}

Autor: Mohamed Bouyakhrichan, Esther H.M Belshof, Jos H. Beijnen, Rianne J. van Maanen, Willy J. M. Underberg, Yunus Kellekule, Auke Bult, J.Léon E. Reubsaet, Ed Hop, Jan Teeuwsen

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 19:277-284

The tripeptides Arg-Trp-Phe, Arg-Trp-Phe-NH2, Phe-Trp-Arg and Phe-Trp-Arg-NH2 were subjected to a degradation study to get a more detailed insight into the degradation processes of the antitumor hexapeptide antagonist [Arg(6), D-Trp(7,9), MePhe(8)] s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf4c0e2a5ab2de09e96f763745ae0ae
https://doi.org/10.1016/s0731-7085(98)00115-0

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Oxidation of recombinant methionyl human granulocyte colony stimulating factor

Autor: Auke Bult, Ed Hop, J.Léon E. Reubsaet, Serge D. Scholten, Willy J. M. Underberg, Jos H. Beijnen, Jan Teeuwsen

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 17:283-289

The oxidation of methionine residues in recombinant methionyl human granulocyte colony stimulating factor with hydrogen peroxide has been investigated. Kinetic data of the oxidation were obtained by using reversed phase-high performance liquid chroma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eaeb1f2e3f6ffd8a0989e9c9068f6d6
https://doi.org/10.1016/s0731-7085(97)00199-4

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Identification of the Degradation Products of Gonadorelin and Three Analogues in Aqueous Solution

Autor: Ed Hop, Willy J. M. Underberg, Jos H. Beijnen, Jack Nijholt, Marcel U. S. Boschma, and Gerard Wiese, Cees Versluis, Auke Bult, Marnix A. Hoitink

Publikováno v: Analytical Chemistry. 69:4972-4978

Degradation products of the peptides gonadorelin and its analogues buserelin, goserelin, and triptorelin were characterized with LC/MS, chiral amino acid analysis, and FAB-MS(-MS). Differences in chemical structures of gonadorelin, its analogues, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a5f040a5267c064bdd24cf57cbb5648
https://doi.org/10.1021/ac970634x

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Degradation of suramin in aqueous solutions

Autor: W Overbeek, Willy J. M. Underberg, Auke Bult, Jos H. Beijnen, Ed Hop, J. J. Kettenes-van den Bosch

Publikováno v: International Journal of Pharmaceutics. 155:27-34

The stability of suramin, a symmetrical urea derivative with a broad pharmacological profile, was investigated in aqueous solution in the pH/H 0 range −1–13, with a validated stability-indicating high-performance liquid chromatographic assay. Bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a107b5c60791c99e2822c6f0495bb15d
https://doi.org/10.1016/s0378-5173(97)00166-x

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Capillary zone electrophoresis–mass spectrometry as a tool in the stability research of the luteinising hormone-releasing hormone analogue goserelin

Autor: Jantien J. Kettenes-van den Bosch, Marnix A. Hoitink, Willy J. M. Underberg, Ed Hop, Auke Bult, Jos H. Beijnen

Publikováno v: Journal of Chromatography A. 776:319-327

A capillary zone electrophoresis (CZE)–MS system for peptide analysis was developed, characterised and applied in the stability research of goserelin, a luteinising hormone-releasing hormone analogue. 10% acetic acid was used as running solution. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36cee2a985aef8069554cea1cef0c3b3
https://doi.org/10.1016/s0021-9673(97)00349-x

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Reduction of Cys36-Cys42 and Cys64-Cys74 disulfide bonds in recombinant human granulocyte colony stimulating factor

Autor: Auke Bult, J. Leon, E. Reubsaet, Willy J. M. Underberg, Arjan J. Hoekstra, Jan Teeuwsen, Jos H. Beijnen, Peter J.H.J. van Os, Wout P. van Bennekom, Ed Hop

Publikováno v: Journal of pharmaceutical and biomedical analysis. 19(6)

The Cys36-Cys42 and Cys64-Cys74 disulfide bonds in recombinant methionyl human granulocyte colony-stimulating factor were reduced to sulfhydryls with dithiothreitol or mercury. Both reduction reactions are dependent on the pH. The reduction reaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519aacb2d6a3ad07ed8e1f34edbd0488
https://pubmed.ncbi.nlm.nih.gov/10698549

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Isolation and structural confirmation of N-desmethyl topotecan, a metabolite of topotecan

Autor: Hilde Rosing, W.W. ten Bokkel Huinink, D. M. Van Gortel-Van Zomeren, V. M. M. Herben, Ed Hop, J. J. Kettenes-van den Bosch, Jos H. Beijnen

Publikováno v: Cancer chemotherapy and pharmacology. 39(6)

A sensitive high-performance liquid chromatography (HPLC) method for the determination of topotecan and total levels of topotecan (lactone plus its ring-opened hydroxycarboxylate form) was developed by the authors and used in several pharmacokinetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4cfdfda18534d81b20f3e02528ecd58
https://pubmed.ncbi.nlm.nih.gov/9118461

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