Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Ed Hop"'
Autor:
C. Sluiter, Auke Bult, Willy J. M. Underberg, Ed Hop, J. J. Kettenes-van den Bosch, O.A.G.J. van der Houwen
Publikováno v:
International Journal of Pharmaceutics. 185:227-235
Clanfenur belongs to a new group of substituted benzoylphenylureas. The drug shows both in vitro and in vivo antitumour activity. To assess its chemical stability, a study was carried out in which the effect of pH, temperature, ionic strength and buf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4e5d24e1b1ecb027ed81d3f81825bc
https://doi.org/10.1016/s0378-5173(99)00160-x
https://doi.org/10.1016/s0378-5173(99)00160-x
Autor:
Mohamed Bouyakhrichan, Esther H.M Belshof, Jos H. Beijnen, Rianne J. van Maanen, Willy J. M. Underberg, Yunus Kellekule, Auke Bult, J.Léon E. Reubsaet, Ed Hop, Jan Teeuwsen
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 19:277-284
The tripeptides Arg-Trp-Phe, Arg-Trp-Phe-NH2, Phe-Trp-Arg and Phe-Trp-Arg-NH2 were subjected to a degradation study to get a more detailed insight into the degradation processes of the antitumor hexapeptide antagonist [Arg(6), D-Trp(7,9), MePhe(8)] s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf4c0e2a5ab2de09e96f763745ae0ae
https://doi.org/10.1016/s0731-7085(98)00115-0
https://doi.org/10.1016/s0731-7085(98)00115-0
Autor:
Auke Bult, Ed Hop, J.Léon E. Reubsaet, Serge D. Scholten, Willy J. M. Underberg, Jos H. Beijnen, Jan Teeuwsen
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 17:283-289
The oxidation of methionine residues in recombinant methionyl human granulocyte colony stimulating factor with hydrogen peroxide has been investigated. Kinetic data of the oxidation were obtained by using reversed phase-high performance liquid chroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eaeb1f2e3f6ffd8a0989e9c9068f6d6
https://doi.org/10.1016/s0731-7085(97)00199-4
https://doi.org/10.1016/s0731-7085(97)00199-4
Autor:
Ed Hop, Willy J. M. Underberg, Jos H. Beijnen, Jack Nijholt, Marcel U. S. Boschma, and Gerard Wiese, Cees Versluis, Auke Bult, Marnix A. Hoitink
Publikováno v:
Analytical Chemistry. 69:4972-4978
Degradation products of the peptides gonadorelin and its analogues buserelin, goserelin, and triptorelin were characterized with LC/MS, chiral amino acid analysis, and FAB-MS(-MS). Differences in chemical structures of gonadorelin, its analogues, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a5f040a5267c064bdd24cf57cbb5648
https://doi.org/10.1021/ac970634x
https://doi.org/10.1021/ac970634x
Autor:
W Overbeek, Willy J. M. Underberg, Auke Bult, Jos H. Beijnen, Ed Hop, J. J. Kettenes-van den Bosch
Publikováno v:
International Journal of Pharmaceutics. 155:27-34
The stability of suramin, a symmetrical urea derivative with a broad pharmacological profile, was investigated in aqueous solution in the pH/H 0 range −1–13, with a validated stability-indicating high-performance liquid chromatographic assay. Bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a107b5c60791c99e2822c6f0495bb15d
https://doi.org/10.1016/s0378-5173(97)00166-x
https://doi.org/10.1016/s0378-5173(97)00166-x
Autor:
Jantien J. Kettenes-van den Bosch, Marnix A. Hoitink, Willy J. M. Underberg, Ed Hop, Auke Bult, Jos H. Beijnen
Publikováno v:
Journal of Chromatography A. 776:319-327
A capillary zone electrophoresis (CZE)–MS system for peptide analysis was developed, characterised and applied in the stability research of goserelin, a luteinising hormone-releasing hormone analogue. 10% acetic acid was used as running solution. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36cee2a985aef8069554cea1cef0c3b3
https://doi.org/10.1016/s0021-9673(97)00349-x
https://doi.org/10.1016/s0021-9673(97)00349-x
Autor:
Auke Bult, J. Leon, E. Reubsaet, Willy J. M. Underberg, Arjan J. Hoekstra, Jan Teeuwsen, Jos H. Beijnen, Peter J.H.J. van Os, Wout P. van Bennekom, Ed Hop
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 19(6)
The Cys36-Cys42 and Cys64-Cys74 disulfide bonds in recombinant methionyl human granulocyte colony-stimulating factor were reduced to sulfhydryls with dithiothreitol or mercury. Both reduction reactions are dependent on the pH. The reduction reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519aacb2d6a3ad07ed8e1f34edbd0488
https://pubmed.ncbi.nlm.nih.gov/10698549
https://pubmed.ncbi.nlm.nih.gov/10698549
Autor:
Hilde Rosing, W.W. ten Bokkel Huinink, D. M. Van Gortel-Van Zomeren, V. M. M. Herben, Ed Hop, J. J. Kettenes-van den Bosch, Jos H. Beijnen
Publikováno v:
Cancer chemotherapy and pharmacology. 39(6)
A sensitive high-performance liquid chromatography (HPLC) method for the determination of topotecan and total levels of topotecan (lactone plus its ring-opened hydroxycarboxylate form) was developed by the authors and used in several pharmacokinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4cfdfda18534d81b20f3e02528ecd58
https://pubmed.ncbi.nlm.nih.gov/9118461
https://pubmed.ncbi.nlm.nih.gov/9118461
Autor:
J.L.E. Reubsaet, Jos H. Beijnen, Y. Kellekule, Willy J. M. Underberg, J. J. Kettenes-Van Den Bosch, R. Vermaas, Auke Bult, Ed Hop
Publikováno v:
Analytical chemistry. 67(23)
The basic hexapeptide antagonist [Arg6,D-Trp7,9,MePhe8]-substance P (6-11) was degraded in acid and alkaline media. In acid solution, only one degradation product is found whereas in alkaline solution at least six products are formed. These compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9912a58df9ed76328f4ba249616943
https://pubmed.ncbi.nlm.nih.gov/8633781
https://pubmed.ncbi.nlm.nih.gov/8633781
Publikováno v:
International Journal of Systems Science; Jun2001, Vol. 32 Issue 6, p715-722, 8p