Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ed E. Moret"'
Autor:
Monique van Scherpenzeel, Federica Conte, Christian Büll, Angel Ashikov, Esther Hermans, Anke Willems, Walinka van Tol, Else Kragt, Marek Noga, Ed E Moret, Torben Heise, Jeroen D Langereis, Emiel Rossing, Michael Zimmermann, M Estela Rubio-Gozalbo, Marien I de Jonge, Gosse J Adema, Nicola Zamboni, Thomas Boltje, Dirk J Lefeber
Publikováno v:
Glycobiology, 32, 3, pp. 239-250
Glycobiology, 32(3), 239-250. Oxford University Press
Glycobiology, 32 (3)
Glycobiology, 32, 239-250
Glycobiology, 32(3), 239-250. Oxford University Press
Glycobiology, 32 (3)
Glycobiology, 32, 239-250
Synthetic sugar analogs are widely applied in metabolic oligosaccharide engineering (MOE) and as novel drugs to interfere with glycoconjugate biosynthesis. However, mechanistic insights on their exact cellular metabolism over time are mostly lacking.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb415a2be9622239306bb55fcad4a567
https://repository.ubn.ru.nl/handle/2066/248778
https://repository.ubn.ru.nl/handle/2066/248778
Autor:
Gosse J. Adema, Michael B. Zimmermann, Esther Hermans, Emiel Rossing, Thomas J. Boltje, Estela M. Rubio-Gozalbo, Anke P. Willems, Else Kragt, Angel Ashikov, Marien I. de Jonge, Monique van Scherpenzeel, Nicola Zamboni, Torben Heise, Walinka van Tol, Ed E. Moret, Dirk Lefeber, Christian Büll, Jeroen D. Langereis, Federica Conte
Synthetic sugar analogs are widely applied in metabolic oligosaccharide engineering (MOE) and as novel drugs to interfere with glycoconjugate biosynthesis. However, mechanistic insights on their exact metabolism in the cell and over time are mostly l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ade3b0e23c8c642bda7c9bdebdca30e
https://doi.org/10.1101/2020.09.15.288712
https://doi.org/10.1101/2020.09.15.288712
Autor:
Yongzhi, Gao, Matthijs J, van Haren, Ed E, Moret, Johannes J M, Rood, Davide, Sartini, Alessia, Salvucci, Monica, Emanuelli, Pierrick, Craveur, Nicolas, Babault, Jian, Jin, Nathaniel I, Martin
Publikováno v:
Journal of Medicinal Chemistry
Nicotinamide N-methyltransferase (NNMT) catalyzes the methylation of nicotinamide to form N-methylnicotinamide. Overexpression of NNMT is associated with a variety of diseases, including a number of cancers and metabolic disorders, suggesting a role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba590ab88457a15e0f7c54ea07dffd66
https://pubmed.ncbi.nlm.nih.gov/31265285
https://pubmed.ncbi.nlm.nih.gov/31265285
Publikováno v:
Organic & Biomolecular Chemistry. 13:549-560
The protein arginine N-methyltransferases (PRMTs) are a family of enzymes that function by specifically transferring a methyl group from the cofactor S-adenosyl-L-methionine (AdoMet) to the guanidine group of arginine residues in target proteins. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1487a0b25825abc6a4a569cc692fd8d1
https://doi.org/10.1039/c4ob01734j
https://doi.org/10.1039/c4ob01734j
Autor:
Alen, Sevšek, Javier, Sastre Toraño, Linda, Quarles van Ufford, Ed E, Moret, Roland J, Pieters, Nathaniel I, Martin
Publikováno v:
MedChemComm. 8(11)
Alkylated guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol bearing an orthoester moiety were prepared using a concise synthetic protocol. Inhibition assays with a panel of glycosidases revealed that one of the compounds prepared displays pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::15a8b983bb1d54fdfd7ab6121e6e0cbb
https://pubmed.ncbi.nlm.nih.gov/30108721
https://pubmed.ncbi.nlm.nih.gov/30108721
Autor:
Ed E. Moret, Jos H. Beijnen, Kim D. Mooiman, Jan H.M. Schellens, Roel F. Maas-Bakker, Irma Meijerman
Publikováno v:
Drug Metabolism and Disposition. 41:1494-1504
Because cancer is often treated with combination therapy, unexpected pharmacological effects can occur because of drug-drug interactions. Several drugs are able to cause upregulation or downregulation of drug transporters or cytochrome P450 enzymes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89e510d725918c8c6f94bf9618cc585
https://doi.org/10.1124/dmd.113.050971
https://doi.org/10.1124/dmd.113.050971
Publikováno v:
Currents in Pharmacy Teaching and Learning. 5:14-22
Objectives To describe the design, contents, and student evaluation of an Inquiry-Based (IB) elective course on Drug discovery and preclinical drug development in an undergraduate Pharmacy curriculum. Methods The course ‘Development of New Drugs’
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93fc3cae29127a56df8ab87989ab9691
https://doi.org/10.1016/j.cptl.2012.09.009
https://doi.org/10.1016/j.cptl.2012.09.009
Autor:
Ed E. Moret, Hilbert M. Branderhorst, Hilde van Hattum, Ulf J. Nilsson, Roland J. Pieters, Hakon Leffler
Publikováno v:
Journal of Medicinal Chemistry; Vol 56
Inhibitors for galectin-1 and -3 were synthesized from thiodigalactoside and lactosamine by derivatization of the galactose C3. Introduction of 4-phenyl-1H-1,2,3-triazol-1-yl substituents at the thiodigalactoside C3 by CuAAC, targeting arginine–are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f055cd00be845ff1e096cc41d34a06
Autor:
David N. Reinhoudt, Willem Verboom, S.J. Postma Kelder, R.J. Driebergen, Jos H. Beijnen, Lambert H.M. Janssen, J.J.M. Holthuis, Ed E. Moret, P. Lelieveld
Publikováno v:
Recueil des Travaux Chimiques des Pays-Bas. 112:174-185
The concept of bioreductive alkylation as a mechanism of action of aziridinylquinoid anticancer agents has been investigated. The influence of quinone substituents on quinone reduction, on protonation of the aziridines prior to and following quinone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::819fd742c1a3f17dedc9fa9319475c02
https://doi.org/10.1002/recl.19931120216
https://doi.org/10.1002/recl.19931120216
Autor:
Roland J. Pieters, Monique van Scherpenzeel, Ulf J. Nilsson, Lluis Ballell, Ed E. Moret, Rob M. J. Liskamp, Hakon Leffler
Publikováno v:
ChemBioChem. 10:1724-1733
New chemical probes were synthesized to label galectin-3. They are based on the high affinity thiodigalactoside ligand. The probes were synthesized with benzophenone or acetophenone moieties as the photolabel for covalent attachment to the protein. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9c36b64ddda4d87291b2075c255c1b
https://doi.org/10.1002/cbic.200900198
https://doi.org/10.1002/cbic.200900198