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Modular Protein Ligation: A New Paradigm as a Reagent Platform for Pre-Clinical Drug Discovery

Autor: Yong Jiang, Tia Lewis, Patricia M. McCormick, Michael Schaber, Beth Pietrak, Rachel D. Totoritis, Marc A. Holbert, Lawrence M. Szewczuk, Daniel Fornwald, William G. Bonnette, Geoffrey Quinque, Maggie Grimes, Rosalie E. Matico, Ed Dul, Randy K. Bledsoe, Derrick W. Meinhold, Stephanie Chen

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports

Significant resource is spent by drug discovery project teams to generate numerous, yet unique target constructs for the multiple platforms used to drive drug discovery programs including: functional assays, biophysical studies, structural biology, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b0cbe26de02a861c13c08b95ac2b93
http://link.springer.com/article/10.1038/s41598-019-49149-2

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Development of a Cell-Based High Throughput Luciferase Enzyme Fragment Complementation Assay to Identify Nuclear-Factor-E2-Related Transcription Factor 2 Activators

Autor: Thomas D. Sweitzer, Ed Dul, Quinn Lu, Robert S. Ames, Wensheng Xie, Hu Li, Christina S. Pao, Taylor L. Graham

Publikováno v: ASSAY and Drug Development Technologies. 10:514-524

Nuclear-factor-E2-related transcription factor 2 (Nrf2) regulates a large panel of Phase II genes and plays an important role in cell survival. Nrf2 activation has been shown as preventing cigarette smoke-induced alveolar enlargement in mice. Therefo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d29ad14aabc3578c876f193c95e77a
https://doi.org/10.1089/adt.2011.436

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Expression, Purification, and Characterization of an Enzymatically Active Truncated Human Rho-Kinase I (ROCK I) Domain Expressed in Sf-9 Insect Cells

Autor: Ed Dul, Robert B. Kirkpatrick, Sanjay S. Khandekar, Gary K. Smith, Tracey Yi, Gilbert F. Scott, Susan Chen, Lois L. Wrigh, Dennis Lee, Erding Hu

Publikováno v: Protein & Peptide Letters. 13:369-376

Rho Kinase I (ROCK I) is a serine/threonine kinase that is involved in diverse cellular signaling. To further understand the physiological role of ROCK I and to identify and develop potent and selective inhibitors of ROCK I, we have overexpressed and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cba3356a95062d61c34cc4c0d37d41
https://doi.org/10.2174/092986606775974357

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Mutations that Affect the Efficiency of Translation of mRNA for the cII Gene of Coliphage Lambda

Autor: Daniel L. Wulff, Michael E. Mahoney, Ed Dul

Publikováno v: Genetics. 115:585-590

Starting with the λ p RE -strain λctr1 cy3008, which forms clear plaques, we have isolated two mutant strains, λdya2 ctr1 cy3008 and λdya3 ctr1 cy3008, that form plaques with very slightly turbid centers. The dya2 and dya3 mutations lie in the re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646a5170589c9805339951a73520e915
https://doi.org/10.1093/genetics/115.4.585

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