Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Ed, Moran"'
Autor:
Massimo Cavallaro, Ed Moran, Benjamin Collyer, Noel D McCarthy, Christopher Green, Matt J Keeling
Publikováno v:
PLOS Digital Health, Vol 2, Iss 1, p e0000162 (2023)
The accuracy and flexibility of artificial intelligence (AI) systems often comes at the cost of a decreased ability to offer an intuitive explanation of their predictions. This hinders trust and discourage adoption of AI in healthcare, exacerbated by
Externí odkaz:
https://doaj.org/article/2c9489b177814d23b854b4268138fa35
Autor:
Fergus W Hamilton, Matt Thomas, David Arnold, Tom Palmer, Ed Moran, Alexander J Mentzer, Nick Maskell, Kenneth Baillie, Charlotte Summers, Aroon Hingorani, Alasdair MacGowan, Golam M Khandaker, Ruth Mitchell, George Davey Smith, Peter Ghazal, Nicholas J Timpson
Publikováno v:
PLoS Medicine, Vol 20, Iss 1, p e1004174 (2023)
BackgroundSepsis is characterised by dysregulated, life-threatening immune responses, which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in IL6R known to down-regulate IL-6 signalling are associated with improv
Externí odkaz:
https://doaj.org/article/2608ebec05cb45ed9c68e5978c195d71
Publikováno v:
Clinical Infection in Practice, Vol 16, Iss , Pp 100210- (2022)
Background: Most patients with SARS-CoV-2 are non-infectious within 2 weeks, though viral RNA may remain detectable for weeks. However there are reports of persistent SARS-CoV-2 infection, with viable virus and ongoing infectivity months after initia
Externí odkaz:
https://doaj.org/article/e7d4ae14c9e24a948c9cee994924eae3
Autor:
Amy Robinson, Kamaljit Khalsa, Arjun Chandna, John Bowen, Viva Levee, Jan Coebergh, Tom Solomon, Clive Graham, David Turner, Robert Tilley, Tim Jones, Susan Hopkins, Matthew Stevens, Daniel White, Celestine Eshiwe, Anna Goodman, Ramandeep Singh, Robert S Heyderman, Nicholas Davies, Joseph Thompson, Ed Moran, Sarah Kelly, Martin Williams, Rhea O’Regan, Simon Tiberi, Jonathan Lambourne, Naomi Bulteel, Susan Larkin, Ruth McEwen, Hassan Paraiso, Aarti Shah, Martin Wiselka, Sylviane Defres, Ernest Mutengesa, Maria Krutikov, Ruth Owen, David Griffith, David Harvey, Trupti Patel, Brendan Davies, Emma Mclean, Joanna Allen, Ali Khan, Alastair Miller, Ashutosh Deshpande, Christopher Green, Lewis Jones, Mark Melzer, Fiona McGill, Amanda Fife, Nimal Wickramasinghe, Stephanie Harris, Ewan Hunter, Jayne Ellis, Benedict Rogers, Imogen Fordham, Elen Vink, Victoria Ward, Anna Smith, Andrew Rosser, Alison Muir, Ken Woodhouse, John Shone, Iain Crossingham, Ryan Jayesinghe, Eavan Muldoon, Avneet Shahi, Terry John Evans, Jeremy Wong, Eloisa MacLachlan, Amy Chue, Karishma Gokani, Katherine Ajdukiewicz, Lucinda Barrett, Frances Edwards, Adam Usher, Mairi McLeod, Su su Htwe, Grace Duane, Nicholas Wong, Jennifer Poyner, Jenni Crane, Ollie Lloyd, Emma Chisholm, Ildiko Kustos, Sam Sutton, M. Estee Torok, Isobel Ramsay, Monica Ivan, Joshua York, Jennifer Ansett, Maithili Varadarajan, Priya Sekhon, James Cruise, Shivani Kanabar, Mirella Ling, Charlotte Milne, Jayanta Sarma, Aline Wilson, Lynn Urquhart, Sahar Eldirdiri, Leila White, Jody Aberdein, Phillip Simpson, Hnin Hay Mar, Keying Tan, Eint Shwe Zin thein, Mahmoud Aziz, Anthony Cadwgan, Natasha Weston, Salman Zeb, Angela Houston, Louise Wootton, Iona Willingham, Aimee Johnson, Ashley Horsley, Eamonn Trainor, Olivier Gaillemin, Nicholas J Norton, Katie Cheung, Megan Duxbury, Emilie Bellhouse, Helena Brezovjakova, Kanitkar Tanmay, Alexsander Dawidziuk, Razan Saman, Hugh Adler, Elshadai Ejere, Yiwen Soo, Wendy Beadles, Heather Sturgeon, Brodie Cameron, David Chadwick Ben Tomlinson, Claire McGoldrick, Katie McDowell, Mpho Molosiwa, Katherine FlackAdrian Kennedy, Phoebe Cross, Fay Perry, Vithusha Inpadhas, Sarathy Selvam, Vhairi Bateman, Henry Wu, Monika Pasztor, Ajanthiha Karunakaran, Basma Soliman, Andrew Blanshard, Harish Reddy, Helen Chesterfield, Ben Schroeder, Tee Keat Teoh, Sathyavani Subbarao, Caryn RosmarinLucy Bell, Emma McGuire, Robert Serafino, Ishaan Bhide, Karanjeet Sagoo, Indran Balakrishnan, Kajal Patel, Barzo Faris, Graeme Calver, Ricky Singh, Hazel Sanghvi, Mohamed Eltayeb, Rathur Haris
Publikováno v:
BMJ Open, Vol 12, Iss 7 (2022)
Objectives To assess practice in the care of adults with suspected community-acquired bacterial meningitis in the UK and Ireland.Design Retrospective cohort study.Setting 64 UK and Irish hospitals.Participants 1471 adults with community-acquired meni
Externí odkaz:
https://doaj.org/article/5f3d2b2bc42b4354baffd7ae95ec84b4
Autor:
Adedeji, Adekola, Katharine, Ajdukiewicz, David, Birkenhead, Thomas, Blanchard, Antony, Cadwgan, David, Chadwick, John, Cheesbrough, Richard, Cooke, John, Croall, Iain, Crossingham, James, Dunbar, Simon, Ellis, Camelia, Faris, Peter, Flegg, Clive, Graham, Katherine, Gray, Shirley, Hammersley, Kevin, Jones, Matthew, Jones, Ildiko, Kustos, Susan, Larkin, Karim, Mahawish, Sarah, Maxwell, Jane, Minton, Kavya, Mohandas, Martin, Mostert, Ed, Moran, Christopher, Murphy, Monika, Pasztor, Hassan, Paraiso, Nikhil, Premchand, Haris, Rathur, Mark, Roberts, Amy, Robinson, Andrew, Rosser, Stefan, Schumacher, Monty, Silverdale, Philip, Stanley, Neil, Todd, Alastair, Watt, Martin, Wiselka, McGill, Fiona, Griffiths, Michael J, Bonnett, Laura J, Geretti, Anna Maria, Michael, Benedict D, Beeching, Nicholas J, McKee, David, Scarlett, Paula, Hart, Ian J, Mutton, Kenneth J, Jung, Agam, Adan, Guleed, Gummery, Alison, Sulaiman, Wan Aliaa Wan, Ennis, Katherine, Martin, Antony P, Haycox, Alan, Miller, Alastair, Solomon, Tom
Publikováno v:
In The Lancet Infectious Diseases September 2018 18(9):992-1003
Autor:
Fergus W. Hamilton, Matt Thomas, David Arnold, Tom Palmer, Ed Moran, Alexander J. Mentzer, Nick Maskell, Kenneth Baillie, Charlotte Summers, Aroon Hingorani, Alasdair MacGowan, Golam M. Khandaker, Ruth Mitchell, George Davey Smith, Peter Ghazal, Nicholas J. Timpson
Publikováno v:
Hamilton, F W, Thomas, M, Arnold, D, Palmer, T, Moran, E, Mentzer, A J, Maskell, N, Baillie, K, Summers, C, Hingorani, A, MacGowan, A, Khandaker, G M, Mitchell, R, Davey Smith, G, Ghazal, P & Timpson, N J 2023, ' Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death : A mendelian randomisation study ', PLoS Medicine, vol. 20, no. 1, e1004174 . https://doi.org/10.1371/journal.pmed.1004174
Funder: Oxford Biomedical Research Centre
Funder: EU-ERDF
Funder: Wellcome Trust; funder-id: http://dx.doi.org/10.13039/100010269
Funder: GlaxoSmithKline; funder-id: http://dx.doi.org/10.13039/100004330
Funder: Sepsis Research
Funder: EU-ERDF
Funder: Wellcome Trust; funder-id: http://dx.doi.org/10.13039/100010269
Funder: GlaxoSmithKline; funder-id: http://dx.doi.org/10.13039/100004330
Funder: Sepsis Research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f42432e8c6ea2ae4f9de78a1e1360c1
Autor:
Ivan T. Lee, Catherine A. Cosgrove, Patrick Moore, Claire Bethune, Rhiannon Nally, Marcin Bula, Philip A. Kalra, Rebecca Clark, Paul I. Dargan, Marta Boffito, Ray Sheridan, Ed Moran, Thomas C. Darton, Fiona Burns, Dinesh Saralaya, Christopher J. A. Duncan, Patrick Lillie, Alberto San Francisco Ramos, Eva Galiza, Paul T. Heath, Bethany Girard, Christy Parker, Dondi Rust, Shraddha Mehta, Elizabeth de Windt, Andrea Sutherland, Joanne E. Tomassini, Frank J. Dutko, Spyros Chalkias, Weiping Deng, Xing Chen, LaRee Tracy, Honghong Zhou, Jacqueline M. Miller, Rituparna Das
BackgroundOmicron-containing bivalent boosters are available worldwide. Results of a large, randomized, active-controlled study are presented.MethodsThis phase 3, randomized, observer-blind, active-controlled trial in the United Kingdom evaluated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be411cd32fa14d0dade51f9918f29e63
https://doi.org/10.1101/2023.01.24.23284869
https://doi.org/10.1101/2023.01.24.23284869
Autor:
Rajeka Lazarus, Benedicte Querton, Irena Corbic Ramljak, Shailesh Dewasthaly, Juan Carlos Jaramillo, Katrin Dubischar, Michael Krammer, Petronela Weisova, Romana Hochreiter, Susanne Eder-Lingelbach, Christian Taucher, Adam Finn, Claire Bethune, Marta Boffito, Marcin Bula, Fiona M Burns, Rebecca Clark, Dileep Dasyam, Simon Drysdale, Saul Faust, Effrossyni Gkrania-Klotsas, Christopher Green, Hana Hassanin, Paul Heath, Amardeep Heer, Toby Helliwell, Anil Hormis, Philip Kalra, Ed Moran, John Ndikum, Iain Page, David Price, Nick Probert, Mahadev Ramjee, Tommy Rampling, Harpal S Randeva, Stephen Ryder, John Steer, Emma Thompson, David Torku
Publikováno v:
2022, ' Immunogenicity and safety of an inactivated whole-virus COVID-19 vaccine (VLA2001) compared with the adenoviral vector vaccine ChAdOx1-S in adults in the UK (COV-COMPARE) : interim analysis of a randomised, controlled, phase 3, immunobridging trial ', The Lancet Infectious Diseases, vol. 22, no. 12, pp. 1716-1727 . https://doi.org/10.1016/S1473-3099(22)00502-3, https://doi.org/10.1016/S1473-3099(22)00502-3
BackgroundThe Valneva COVID-19 vaccine (VLA2001; Valneva Austria, Vienna, Austria) is an inactivated whole-virus, adjuvanted SARS-CoV-2 vaccine. We aimed to assess the safety and immunogenicity of primary vaccination with VLA2001 versus the ChAdOx1-S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f65e657505d72fb360ce88922221cf
https://hdl.handle.net/1983/8151ad0f-2432-43b1-a576-b9932a00559e
https://hdl.handle.net/1983/8151ad0f-2432-43b1-a576-b9932a00559e
Autor:
Massimo Cavallaro, Ed Moran, Benjamin Collyer, Noel D. McCarthy, Christopher Green, Matt J. Keeling
The accuracy and flexibility of artificial intelligence (AI) systems often comes at the cost of a decreased ability to offer an intuitive explanation of their predictions. This hinders trust and discourage adoption of AI in healthcare, exacerbated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed254d7abc0883b3164428c0a7caa1f6
https://doi.org/10.1101/2022.08.12.22278678
https://doi.org/10.1101/2022.08.12.22278678
Autor:
Fergus Hamilton, Matt Thomas, David Arnold, Tom Palmer, Ed Moran, Alexander J Mentzer, Nick Maskell, Kenneth Baillie, Charlotte Summers, Aroon Hingorani, Alasdair MacGowan, Golam M Khandakar, Ruth Mitchell, George Davey Smith, Peter Ghazal, Nicholas J Timpson
IntroductionSepsis is characterised by dysregulated, life-threatening immune responses, which are thought to be driven by cytokines such as interleukin-6 (IL-6). Genetic variants in IL6R known to downregulate IL-6 signalling are associated with impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::223c582e4a5ed12bae4c3d1fe70b8183
https://doi.org/10.1101/2022.07.14.22277638
https://doi.org/10.1101/2022.07.14.22277638