Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

Autor: Luth MR; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Godinez-Macias KP; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Chen D; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Okombo J; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Thathy V; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Cheng X; Global Health Drug Discovery Institute, Beijing, China., Daggupati S; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Davies H; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Dhingra SK; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Economy JM; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Edgar RCS; Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Gomez-Lorenzo MG; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., Istvan ES; Department of Internal Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA., Jado JC; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., LaMonte GM; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Melillo B; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA., Mok S; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Narwal SK; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Ndiaye T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Ottilie S; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Palomo Diaz S; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., Park H; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Peña S; Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Montevideo, Uruguay., Rocamora F; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Sakata-Kato T; Global Health Drug Discovery Institute, Beijing, China.; Department of Protozoology, Nekken Institute for Tropical Medicine, Nagasaki University, Nagasaki, Japan., Small-Saunders JL; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Summers RL; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Tumwebaze PK; Infectious Diseases Research Collaboration, Kampala, Uganda., Vanaerschot M; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Xia G; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Yeo T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., You A; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Gamo FJ; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., Goldberg DE; Department of Internal Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA., Lee MCS; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., McNamara CW; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA., Ndiaye D; Centre International de Recherche et de Formation en Génomique Appliquée et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Rosenthal PJ; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Schreiber SL; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Serra G; Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Montevideo, Uruguay., De Siqueira-Neto JL; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA., Skinner-Adams TS; Institute for Biomedicine and Glycomics and School of Environment and Science, Griffith University, Nathan, QLD, Australia., Uhlemann AC; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Kato N; Global Health Drug Discovery Institute, Beijing, China.; Department of Protozoology, Nekken Institute for Tropical Medicine, Nagasaki University, Nagasaki, Japan., Lukens AK; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Wirth DF; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Winzeler EA; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Nov 29; Vol. 386 (6725), pp. eadk9893. Date of Electronic Publication: 2024 Nov 29.