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Global Proteomic Analysis Reveals Alterations in Differentially Expressed Proteins between Cardiopathic Lamin A/C Mutations.

Autor: Anderson CL; Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Brown KA; Department of Cell and Regenerative Biology, Human Proteomics Program, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., North RJ; Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Walters JK; Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Kaska ST; Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Wolff MR; Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Kamp TJ; Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Ge Y; Department of Cell and Regenerative Biology, Human Proteomics Program, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Eckhardt LL; Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.

Publikováno v: Journal of proteome research [J Proteome Res] 2024 Jun 07; Vol. 23 (6), pp. 1970-1982. Date of Electronic Publication: 2024 May 08.

Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias.

Autor: Weng LC; Cardiovascular Research Center (L.-C.W.), The Broad Institute of MIT and Harvard, Cambridge.; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; VA Boston Healthcare System (L.-C.W., V.N., T.M.T., J.M.G., K.C.), Brigham and Women's Hospital, Boston, MA., Khurshid S; Demoulas Center for Cardiac Arrhythmias (S. Khurshid, P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge., Hall AW; Gene Regulation Observatory (A.W.H.), The Broad Institute of MIT and Harvard, Cambridge., Nauffal V; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; VA Boston Healthcare System (L.-C.W., V.N., T.M.T., J.M.G., K.C.), Brigham and Women's Hospital, Boston, MA., Morrill VN; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge., Sun YV; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA (Y.V.S.).; VA Atlanta Healthcare System, Decatur, GA (Y.V.S., P.W.F.W.)., Rämö JT; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Finland (J.T.R., A.P.)., Beer D; Heart Institute (D.B., C.M.H.), Geisinger, Danville, PA., Lee S; Icahn School of Medicine at Mount Sinai, New York, NY (S.L., G.N.)., Nadkarni G; Icahn School of Medicine at Mount Sinai, New York, NY (S.L., G.N.)., Johnson R; Victor Chang Cardiac Research Institute (R.J., R.S., D.F.), Darlinghurst, NSW.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW, Australia (R.J., R.S., B.W., D.F.)., Andreasen L; Department of Cardiology, Laboratory for Molecular Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark (L.A., J.P.H., J.H.S., M.S.O.).; Department of Biomedical Sciences (L.A., M.S.O.), University of Copenhagen, Denmark., Clayton A; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT (A.C., H.T.M., S. Knight, M.J.C.)., Pullinger CR; Cardiovascular Research Institute and Department of Physiological Nursing (C.R.P.), University of California, San Francisco., Yoneda ZT; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN (Z.T.Y., M.B.S.)., Friedman DJ; Division of Cardiology, Department of Medicine (D.J.F., N.A.N., S.H.S.), Duke University School of Medicine, Durham, NC., Hyman MC; Division of Cardiac Electrophysiology, Hospital of the University of Pennsylvania, Philadelphia (M.C.H.)., Judy RL; Department of Surgery (R.L.J.), University of Pennsylvania, Philadelphia., Skanes AC; Division of Cardiology, Department of Medicine, Section of Cardiac Electrophysiology, Western University, London, ON, Canada (A.C.S., P.L.-S., H.R.K., J.D.R.)., Orland KM; Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, WI (K.M.O., L.L.E.)., Jordà P; Montreal Heart Institute Research Center and Faculty of Medicine, Université de Montréal, QC, Canada (P.J., M.-P.D., J.-C.T., R.T.)., Treu TM; VA Boston Healthcare System (L.-C.W., V.N., T.M.T., J.M.G., K.C.), Brigham and Women's Hospital, Boston, MA., Oetjens MT; Autism and Developmental Medicine Institute, Geisinger, Lewisburg, PA (M.T.O., R.K.L.)., Subbiah R; Victor Chang Cardiac Research Institute (R.J., R.S., D.F.), Darlinghurst, NSW.; St Vincent's Hospital (R.S., B.W., D.F.), Darlinghurst, NSW.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW, Australia (R.J., R.S., B.W., D.F.)., Hartmann JP; Department of Cardiology, Laboratory for Molecular Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark (L.A., J.P.H., J.H.S., M.S.O.)., May HT; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT (A.C., H.T.M., S. Knight, M.J.C.)., Kane JP; Cardiovascular Research Institute (J.P.K.), University of California, San Francisco.; Department of Medicine, Department of Biochemistry and Biophysics (J.P.K.), University of California, San Francisco., Issa TZ; Feinberg School of Medicine, Northwestern University, Chicago, IL (T.Z.I.)., Nafissi NA; Division of Cardiology, Department of Medicine (D.J.F., N.A.N., S.H.S.), Duke University School of Medicine, Durham, NC., Leong-Sit P; Division of Cardiology, Department of Medicine, Section of Cardiac Electrophysiology, Western University, London, ON, Canada (A.C.S., P.L.-S., H.R.K., J.D.R.)., Dubé MP; Montreal Heart Institute Research Center and Faculty of Medicine, Université de Montréal, QC, Canada (P.J., M.-P.D., J.-C.T., R.T.).; Beaulieu-Saucier Pharmacogenomics Center, Montreal, QC, Canada (M.-P.D.)., Roselli C; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (C.R.)., Choi SH; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge., Tardif JC; Montreal Heart Institute Research Center and Faculty of Medicine, Université de Montréal, QC, Canada (P.J., M.-P.D., J.-C.T., R.T.)., Khan HR; Division of Cardiology, Department of Medicine, Section of Cardiac Electrophysiology, Western University, London, ON, Canada (A.C.S., P.L.-S., H.R.K., J.D.R.)., Knight S; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT (A.C., H.T.M., S. Knight, M.J.C.).; Department of Medicine, University of Utah, Salt Lake City (S. Knight)., Svendsen JH; Department of Cardiology, Laboratory for Molecular Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark (L.A., J.P.H., J.H.S., M.S.O.).; Department of Clinical Medicine (J.H.S.), University of Copenhagen, Denmark., Walker B; St Vincent's Hospital (R.S., B.W., D.F.), Darlinghurst, NSW.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW, Australia (R.J., R.S., B.W., D.F.)., Karlsson Linnér R; Autism and Developmental Medicine Institute, Geisinger, Lewisburg, PA (M.T.O., R.K.L.).; Department of Economics, Leiden Law School, Leiden University, the Netherlands (R.K.L.)., Gaziano JM; VA Boston Healthcare System (L.-C.W., V.N., T.M.T., J.M.G., K.C.), Brigham and Women's Hospital, Boston, MA.; Harvard Medical School, Boston, MA (J.M.G.)., Tadros R; Montreal Heart Institute Research Center and Faculty of Medicine, Université de Montréal, QC, Canada (P.J., M.-P.D., J.-C.T., R.T.)., Fatkin D; Victor Chang Cardiac Research Institute (R.J., R.S., D.F.), Darlinghurst, NSW.; St Vincent's Hospital (R.S., B.W., D.F.), Darlinghurst, NSW.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW, Australia (R.J., R.S., B.W., D.F.)., Rader DJ; Division of Cardiovascular Medicine, Department of Medicine (D.J.R.), University of Pennsylvania, Philadelphia., Shah SH; Division of Cardiology, Department of Medicine (D.J.F., N.A.N., S.H.S.), Duke University School of Medicine, Durham, NC.; Duke Molecular Physiology Institute (S.H.S.), Duke University School of Medicine, Durham, NC., Roden DM; Vanderbilt University Medical Center, Nashville, TN (D.M.R.)., Marcus GM; Division of Cardiology (G.M.M.), University of California, San Francisco., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (R.J.F.L.)., Damrauer SM; Department of Surgery and Department of Genetics, Perelman School of Medicine (S.M.D.), University of Pennsylvania, Philadelphia.; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (S.M.D.)., Haggerty CM; Heart Institute (D.B., C.M.H.), Geisinger, Danville, PA.; Department of Translational Data Science and Informatics (C.M.H.), Geisinger, Danville, PA., Cho K; VA Boston Healthcare System (L.-C.W., V.N., T.M.T., J.M.G., K.C.), Brigham and Women's Hospital, Boston, MA., Palotie A; Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology, Department of Psychiatry (A.P.), The Broad Institute of MIT and Harvard, Cambridge.; The Stanley Center for Psychiatric Research & Program in Medical & Population Genetics (A.P.), The Broad Institute of MIT and Harvard, Cambridge.; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Finland (J.T.R., A.P.)., Olesen MS; Department of Cardiology, Laboratory for Molecular Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark (L.A., J.P.H., J.H.S., M.S.O.).; Department of Biomedical Sciences (L.A., M.S.O.), University of Copenhagen, Denmark., Eckhardt LL; Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, WI (K.M.O., L.L.E.)., Roberts JD; Division of Cardiology, Department of Medicine, Section of Cardiac Electrophysiology, Western University, London, ON, Canada (A.C.S., P.L.-S., H.R.K., J.D.R.)., Cutler MJ; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT (A.C., H.T.M., S. Knight, M.J.C.)., Shoemaker MB; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN (Z.T.Y., M.B.S.)., Wilson PWF; Department of Medicine, Emory University School of Medicine, Atlanta, GA (P.W.F.W.)., Ellinor PT; Demoulas Center for Cardiac Arrhythmias (S. Khurshid, P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; VA Atlanta Healthcare System, Decatur, GA (Y.V.S., P.W.F.W.)., Lubitz SA; Demoulas Center for Cardiac Arrhythmias (S. Khurshid, P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.

Publikováno v: Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2024 Jun; Vol. 17 (3), pp. e004320. Date of Electronic Publication: 2024 May 28.