Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Eckhard Jankowsky"'
Autor:
Thilini Abeywansha, Wei Huang, Xuan Ye, Allison Nawrocki, Xin Lan, Eckhard Jankowsky, Derek J. Taylor, Yi Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Arginyl-tRNA-protein transferase 1 (ATE1) is a master regulator of protein homeostasis, stress response, cytoskeleton maintenance, and cell migration. The diverse functions of ATE1 arise from its unique enzymatic activity to covalently attac
Externí odkaz:
https://doaj.org/article/bd567ad855694ce5bcdeca9731c3b665
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Here the authors show that the RRM of RbFox accomplishes extraordinary sequence specificity by employing functionally and structurally distinct binding modes - one for its cognate RNA and one for all non-cognate RNAs.
Externí odkaz:
https://doaj.org/article/de89be8100a24a9ebd3bc7dbb2f9e749
Autor:
Bartosz Mucha, Shuo Qie, Sagar Bajpai, Vincenzo Tarallo, J. Nathaniel Diehl, Frank Tedeschi, Gao Zhou, Zhaofeng Gao, Samuel Flashner, Andres J. Klein-Szanto, Hanina Hibshoosh, Shimonosono Masataka, Olga S. Chajewski, Ireneusz Majsterek, Dariusz Pytel, Maria Hatzoglou, Channing J. Der, Hiroshi Nakagawa, Adam J. Bass, Kwok-Kin Wong, Serge Y. Fuchs, Anil K. Rustgi, Eckhard Jankowsky, J. Alan Diehl
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Cytoplasmic accumulation of RNA binding protein, hnRNPK in cancer cells is associated with poor prognosis. Here the authors show that SCFFbxo4 E3 ubiquitin ligase-mediated polyubiquitylation of hnRNPK restricts c-Myc translation and limits cancer pro
Externí odkaz:
https://doaj.org/article/fecd2f81e26b43a3b3aad7932728969f
Autor:
W. Michael Babinchak, Benjamin K. Dumm, Sarah Venus, Solomiia Boyko, Andrea A. Putnam, Eckhard Jankowsky, Witold K. Surewicz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Dysregulated liquid-liquid phase separation (LLPS) of proteins can facilitate aberrant phase transitions and lead to protein aggregation and disease. Here, authors demonstrate that 4,4’-dianilino-1,1’-binaphthyl-5,5’-disulfonic acid (bis-ANS) a
Externí odkaz:
https://doaj.org/article/1546e39d54c649998d644f397e8e1d40
Autor:
Zhaofeng Gao, Andrea A Putnam, Heath A Bowers, Ulf-Peter Guenther, Xuan Ye, Audrey Kindsfather, Angela K Hilliker, Eckhard Jankowsky
Publikováno v:
eLife, Vol 5 (2016)
Eukaryotic translation initiation involves two conserved DEAD-box RNA helicases, eIF4A and Ded1p. Here we show that S. cerevisiae eIF4A and Ded1p directly interact with each other and simultaneously with the scaffolding protein eIF4G. We delineate a
Externí odkaz:
https://doaj.org/article/32b74e867b61434bbce9602bd54e81fd
Autor:
Anupama Rao, Baken Lyu, Ishrat Jahan, Anna Lubertozzi, Gao Zhou, Frank Tedeschi, Eckhard Jankowsky, Junsu Kang, Bryan Carstens, Ken Poss, Kedryn Baskin, Joseph Aaron Goldman
Publikováno v:
Development.
The eIF4E family of translation initiation factors bind 5’ methylated caps and act as the limiting-step for mRNA translation. The canonical eIF4E1A is required for cell viability, yet other related eIF4E families exist and are utilized in specific
Publikováno v:
PNAS Nexus.
A major cause for childhood blindness worldwide is attributed to nutritional vitamin A deficiency. Surprisingly, the molecular basis of the ensuing retinal degeneration has not been well defined. Abundant expression of the retinoid transporter STRA6
Autor:
Anupama Rao, Baken Lyu, Ishrat Jahan, Anna Lubertozzi, Gao Zhou, Frank Tedeschi, Eckhard Jankowsky, Junsu Kang, Bryan Carstens, Ken Poss, Kedryn Baskin, Joseph Aaron Goldman
The eIF4E family of translation initiation factors bind 5’ methylated caps and act as the limiting-step for mRNA translation. The canonical eIF4E1A is required for cell viability, yet other related eIF4E families exist and are utilized in specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c92bff267291e0862f937264b0a3ce47
https://doi.org/10.1101/2022.08.15.502524
https://doi.org/10.1101/2022.08.15.502524
Autor:
Anthony Sloan, Christine Lee-Poturalski, Harry Hoffman, Peggy Harris, Theresa Elder, Gino Cioffi, Jill Barnholtz-Sloan, Jeremy N Rich, Eckhard Jankowsky, Anirban Sen Gupta, Andrew Sloan
Publikováno v:
Neuro-Oncology. 24:vii30-vii31
The interaction between platelets and cancer cells has been underexplored in solid tumor models that do not metastasize, for example glioblastoma (GBM) for which metastasis is rare. Histologically, it is known that glioma stem cells (GSCs) are found
Publikováno v:
RNA. 27:465-476
The 3′ to 5′ exonuclease Pop2p (Caf1p) is part of the CCR4-NOT deadenylation complex that removes poly(A) tails from mRNAs in cells. Pop2p is structurally conserved in eukaryotes, but Saccharomyces cerevisiae Pop2p harbors noncanonical amino acid