Výsledky vyhledávání - "Eckhard Guenther"

Translational potential of the ghrelin receptor agonist macimorelin for seizure suppression in pharmacoresistant epilepsy

Autor: Ilse Julia Smolders, Dimitri De Bundel, Eckhard Guenther, Ron Kooijman, Yana Van Den Herrewegen, An Buckinx, Anouk Pierre, Gaetan Van Laethem, Matthias Gerlach

Publikováno v: European Journal of Neurology. 28:3100-3112

Background Current drugs for epilepsy affect seizures, but no antiepileptogenic or disease-modifying drugs are available that prevent or slow down epileptogenesis, which is characterized by neuronal cell loss, inflammation and aberrant network format

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a417a4cdcc3d4ef7c2e2e120048f29d
https://doi.org/10.1111/ene.14992

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Abstract 2877: Perifosine alone and in combination with antimetabolites interferes with NF-kB pathway activation in colon cancer cell lines

Autor: Babette Aicher, Peter Schmidt, Jürgen Engel, Eckhard Guenther, Michael Teifel

Publikováno v: Cancer Research. 72:2877-2877

Background: Perifosine, a novel, first-in-class, oral Akt inhibitor, in combination with the antimetabolite Capecitabine is currently in Phase III clinical trials for the treatment of refractory advanced colorectal cancer. We have shown previously th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17dcf6e1f40c2acfb718b4e1cd09c861
https://doi.org/10.1158/1538-7445.am2012-2877

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Abstract 871: Dual inhibition of PI3K and Erk1/2 shows synergy and efficacy in human tumor cells, either by using drug combinations or novel dual PI3K/Erk inhibitors

Autor: Gilbert Mueller, Michael Teifel, Irene Seipelt, Eckhard Guenther, Lars Blumenstein, Matthias Gerlach, Jürgen Engel

Publikováno v: Cancer Research. 72:871-871

The Ras/Raf/Mek/Erk and the PI3K/Akt signaling pathways are frequently deregulated in cancer due to activation of upstream receptors, decreased expression of tumor suppressors like PTEN or activating mutations of Ras, B-Raf or PI3K. Several clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fac5061642b2c8f4e0234c429bc8163
https://doi.org/10.1158/1538-7445.am2012-871

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Abstract 3563: A highly selective Erk1/2 Inhibitor with in-vivo anti tumor potency

Autor: Matthias Gerlach, Eckhard Guenther, Michael Teifel, Babette Aicher, Irene Seipelt, Peter Schmidt, Lars Blumenstein, Gilbert Mueller

Publikováno v: Cancer Research. 71:3563-3563

Mutations in receptor tyrosine kinases, Ras or B-Raf frequently manifest constitutive activation of the Ras/Raf/Mek/Erk pathway in a variety of human cancers. The mitogen activated protein kinase Erk1/2 is an important regulator of cell proliferation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76a790f0dc5a8c97b983419a4adedd05
https://doi.org/10.1158/1538-7445.am2011-3563

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Abstract 4474: Dual inhibitors for PI3K and Erk induce growth inhibition of tumor cells

Autor: Matthias Gerlach, Babette Aicher, Michael Teifel, Irene Seipelt, Lars Blumenstein, Eckhard Guenther, Gilbert Mueller, Silke Baasner

Publikováno v: Cancer Research. 70:4474-4474

The Ras/Raf/Mek/Erk and the PI3K-Akt signaling pathways are prime targets for drug discovery in proliferative diseases such as cancer. The results of research to date indicate that both the MAPK and the PI3K signaling pathways represent therapeutic i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ce06f09f534c6d0d7c964dfe8d9d2b0
https://doi.org/10.1158/1538-7445.am10-4474

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Abstract 3856: A highly selective Erk-inhibitor with antiproliferative efficacy and the potential for combination therapy with modulators of the PI3K pathway

Autor: Matthias Gerlach, Eckhard Guenther, Michael Teifel, Irene Seipelt, Babette Aicher, Gilbert Mueller, Silke Baasner, Lars Blumenstein

Publikováno v: Cancer Research. 70:3856-3856

The Ras/Raf/Mek/Erk signal transduction is a key oncogenic pathway in a variety of human cancers. The mitogen activated protein kinase Erk is an important regulator of cell proliferation and was shown to be over-activated by dysregulated or mutated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0c5d6d887e6764ba2614b7b6766cbe8
https://doi.org/10.1158/1538-7445.am10-3856

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