Zobrazeno 1 - 10
of 345
pro vyhledávání: '"Eckard Wimmer"'
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT The Flavivirus genus of the Flaviviridae family encompasses numerous enveloped plus-strand RNA viruses. Dengue virus (DENV), a flavivirus, is the leading cause of serious arthropod-borne disease globally. The genomes of DENV, like the genome
Externí odkaz:
https://doaj.org/article/225a4dbc202845aeba1944777453e50f
Autor:
Charles B Stauft, Sam H Shen, Yutong Song, Oleksandr Gorbatsevych, Emmanuel Asare, Bruce Futcher, Steffen Mueller, Anne Payne, Matthew Brecher, Laura Kramer, Eckard Wimmer
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0198303 (2018)
Dengue virus (DENV), an arthropod-borne ("arbovirus") virus, causes a range of human maladies ranging from self-limiting dengue fever to the life-threatening dengue shock syndrome and proliferates well in two different taxa of the Animal Kingdom, mos
Externí odkaz:
https://doaj.org/article/7841837943844519af6eb2320bce9b67
Autor:
Barbara P Sanders, Isabel de Los Rios Oakes, Vladimir van Hoek, Viki Bockstal, Tobias Kamphuis, Taco G Uil, Yutong Song, Gillian Cooper, Laura E Crawt, Javier Martín, Roland Zahn, John Lewis, Eckard Wimmer, Jerome H H V Custers, Hanneke Schuitemaker, Jeronimo Cello, Diana Edo-Matas
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005483 (2016)
The poliovirus vaccine field is moving towards novel vaccination strategies. Withdrawal of the Oral Poliovirus Vaccine and implementation of the conventional Inactivated Poliovirus Vaccine (cIPV) is imminent. Moreover, replacement of the virulent pol
Externí odkaz:
https://doaj.org/article/a19a756d47b84c37acdf280f63f2db04
Autor:
Bingyin Wang, Chen Yang, Gergely Tekes, Steffen Mueller, Aniko Paul, Sean P. J. Whelan, Eckard Wimmer
Publikováno v:
mBio, Vol 6, Iss 2 (2015)
ABSTRACT Codon pair bias (CPB), which has been observed in all organisms, is a neglected genomic phenomenon that affects gene expression. CPB results from synonymous codons that are paired more or less frequently in ORFeomes regardless of codon bias.
Externí odkaz:
https://doaj.org/article/f6b22fa52b7d4a6eb4bb2ee70f7abc01
Publikováno v:
BioTechniques, Vol 32, Iss 1, Pp 134-141 (2002)
The suitability of synchrotron radiation-induced X-ray emission (SRIXE) for the detection and identification of metal ions in preparations of purified, soluble proteins was tested. Glutathione S-transferase fused to the proximal zinc finger motif of
Externí odkaz:
https://doaj.org/article/146825d605d041e683eac14829e53887
Autor:
Hendrik Jan Thibaut, Lonneke van der Linden, Ping Jiang, Bert Thys, María-Dolores Canela, Leire Aguado, Bart Rombaut, Eckard Wimmer, Aniko Paul, María-Jesús Pérez-Pérez, Frank J M van Kuppeveld, Johan Neyts
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004039 (2014)
Enteroviruses (family of the Picornaviridae) cover a large group of medically important human pathogens for which no antiviral treatment is approved. Although these viruses have been extensively studied, some aspects of the viral life cycle, in parti
Externí odkaz:
https://doaj.org/article/3a31551959154d10b2a8714b46cf2715
Autor:
Hsin-Chieh Ma, Ying Liu, Chunling Wang, Michael Strauss, Nina Rehage, Ying-Han Chen, Nihal Altan-Bonnet, James Hogle, Eckard Wimmer, Steffen Mueller, Aniko V Paul, Ping Jiang
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004052 (2014)
Glutathione (GSH) is the most abundant cellular thiol playing an essential role in preserving a reduced cellular environment. Cellular GSH levels can be efficiently reduced by the GSH biosynthesis inhibitor, L-buthionine sulfoximine (BSO). The aim of
Externí odkaz:
https://doaj.org/article/a6d83bff16384729b183bf81004b6578
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60791 (2013)
The internal ribosomal entry site (IRES) of picornavirus genomes serves as the nucleation site of a highly structured ribonucleoprotein complex essential to the binding of the 40S ribosomal subunit and initiation of viral protein translation. The tra
Externí odkaz:
https://doaj.org/article/d4d593589b194a238af944df160f210f
Publikováno v:
PLoS Pathogens, Vol 6, Iss 8, p e1001066 (2010)
In spite of decades-long studies, the mechanism of morphogenesis of plus-stranded RNA viruses belonging to the genus Enterovirus of Picornaviridae, including poliovirus (PV), is not understood. Numerous attempts to identify an RNA encapsidation signa
Externí odkaz:
https://doaj.org/article/690760a7ced04845b3c2270ad059382a
Autor:
Alfredo Castelló, David Franco, Pablo Moral-López, Juan J Berlanga, Enrique Alvarez, Eckard Wimmer, Luis Carrasco
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7997 (2009)
A number of viral proteases are able to cleave translation initiation factors leading to the inhibition of cellular translation. This is the case of human immunodeficiency virus type 1 protease (HIV-1 PR), which hydrolyzes eIF4GI and poly(A)-binding
Externí odkaz:
https://doaj.org/article/7b908a151b204eba98257ae5ecdac5c6