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Zebrafish as outgroup model to study evolution of scavenger receptor class B type I functions

Autor: Verwilligen, R.A.F., Mulder, L., Araujo, P.M., Carneiro, M., Bussmann, J., Hoekstra, M., Eck, M. van

Publikováno v: Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1868(6), 159308. ELSEVIER

Background and aims: Scavenger receptor class B1 (SCARB1) -also known as the high-density lipoprotein (HDL) receptor -is a multi-ligand scavenger receptor that is primarily expressed in liver and steroidogenic organs. This receptor is known for its f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4c5721d63edc553261101eaac55335
https://doi.org/10.1016/j.bbalip.2023.159308

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2-Hydroxypropyl-beta-cyclodextrin treatment does not induce atherosclerotic lesion regression in Western-type diet-fed apolipoprotein E knockout mice

Autor: Snip, O.S.C., Hoekstra, M., Zhang, Y., Geerling, J.J., Eck, M. van

Publikováno v: Biomolecules, 12(9):1205. MDPI
Biomolecules; Volume 12; Issue 9; Pages: 1205

2-Hydroxypropyl-beta-cyclodextrin (2HP beta CD) is able to bind and solubilize unesterified cholesterol and may therefore be able to reverse the deposition of cholesterol in macrophages within the aortic vessel wall, a hallmark of atherosclerotic car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefd0b298bc860acdcaf0778d8dd1ec6
http://hdl.handle.net/1887/3505425

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Bescherming gegeven? Evaluatie UAVG, meldplicht datalekken en de boetebevoegdheid

Autor: Winter, Heinrich, Drouen, T., Eck, M. van, Geertsema, B., Cazemier, J., Ridderbos-Hovingh, C.

De overkoepelende vraag die in het onderzoek centraal staat luidt als volgt: Hoe werden in de periode 2018 - 2020 de normen van de Uitvoeringswet Algemene Verordening Gegevensbescherming (UAVG) nageleefd en in hoeverre heeft de UAVG bijgedragen aan e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::0c12dd975645975952cfb00f3b7a69ed
https://research.rug.nl/en/publications/41021f47-8902-4d55-8e9f-4f783a02c75f

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Hypocholesterolemic phospholipid transfer protein knockout mice exhibit a normal glucocorticoid response to food deprivation

Autor: Hoekstra, M., Liu, Q., Zhang, Y.H., Wel, E.J. van der, Le Devedec, S.E., Eck, M. van

Publikováno v: American Journal of Translational Research, 14(3), 1884-1891. E-CENTURY PUBLISHING CORP

Objectives: Glucocorticoids, adrenal-derived steroid hormones, facilitate the physiological response to stress. High-density lipoproteins (HDL) are considered the primary source of cholesterol used for glucocorticoid synthesis in mice. Phospholipid t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::55e4eb0a57c9006592c762c9fabade50
http://hdl.handle.net/1887/3492052

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Corrigendum to 'Proteoglycan 4 regulates macrophage function without altering atherosclerotic lesion formation in a murine bone marrow-specific deletion model'

Autor: Nahon, J.E., Hoekstra, M., Havik, S.R., Santbrink, P.J. van, Dallinga-Thie, G.M., Kuivenhoven, J.A., Geerling, J.J., Eck, M. van

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::de31f9180917426d04b74a408f295f00
http://hdl.handle.net/1887/3203169

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Lipoproteins as modulators of atherothrombosis: From endothelial function to primary and secondary coagulation

Autor: Ouweneel, A.B., Eck, M. van

Publikováno v: Vascular Pharmacology. 82:1-10

Atherothrombosis is a complication of atherosclerosis that causes acute cardiovascular events such as myocardial infarction and stroke. Circulating lipid levels are highly correlated with atherosclerotic plaque development. In addition, experimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7090028160e2d6852c93903a5032a0b7
https://doi.org/10.1016/j.vph.2015.10.009

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Inhibition of protein arginine methyltransferase 3 activity selectively impairs liver X receptor-driven transcription of hepatic lipogenic genes in vivo

Autor: Nahon, J.E., Groeneveldt, C., Geerling, J.J., Eck, M. van, Hoekstra, M.

Publikováno v: British Journal of Pharmacology, 175(15), 3175-3183

Agonists for the liver X receptor (LXR) are considered promising therapeutic moieties in cholesterol-driven diseases by promoting cellular cholesterol efflux pathways. However, current clinical application of these agents is hampered by concomitant L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c846ccedb1792885be3cdcd5f24a7e89
http://hdl.handle.net/1887/67192

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