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Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca ²⁺ and Mg ²⁺ in the formulation.

Autor: Miller R; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605.; Department of Medicine, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605., Paquette J; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605.; Department of Medicine, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605., Barker A; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605.; Department of Medicine, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605., Sapp E; MassGeneral Institute for Neurodegenerative Disease, 114 16 Street, Charlestown MA, 02129., McHugh N; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605., Bramato B; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605., Yamada N; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605., Alterman J; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605., Echeveria D; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605., Yamada K; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605., Watts J; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605., Anaclet C; Department of Neurologic Surgery, University of California Davis School of Medicine, Davis, CA, 95618., DiFiglia M; MassGeneral Institute for Neurodegenerative Disease, 114 16 Street, Charlestown MA, 02129., Khvorova A; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605., Aronin N; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605.; Department of Medicine, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA, 01605.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 08. Date of Electronic Publication: 2024 Jun 08.