Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells

Autor: Rata, S, Suarez Peredo Rodriguez, M, Joseph, S, Peter, N, Echegaray Iturra, F, Yang, F, Madzvamuse, A, Ruppert, J, Samejima, K, Platani, M, Alvarez-Fernandez, M, Malumbres, M, Earnshaw, W, Novak, B, Hochegger, H

Publikováno v: Current Biology
Rata, S, Suarez Peredo Rodriguez, M F, Joseph, S, Peter, N, Echegaray Iturra, F, Yang, F, Madzvamuse, A, Ruppert, J G, Samejima, K, Platani, M, Alvarez-Fernandez, M, Malumbres, M, Earnshaw, W C, Novak, B & Hochegger, H 2018, ' Two interlinked bistable switches govern mitotic control in mammalian cells ', Current Biology, vol. 28, no. 23, pp. 3824-3832.e6 . https://doi.org/10.1016/j.cub.2018.09.059

Summary Distinct protein phosphorylation levels in interphase and M phase require tight regulation of Cdk1 activity [1, 2]. A bistable switch, based on positive feedback in the Cdk1 activation loop, has been proposed to generate different thresholds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::38f1f311639b273b7ded176a5c37101e
http://europepmc.org/articles/PMC6287978

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