Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Ecem Kirkiz"'
Publikováno v:
HemaSphere, Vol 7, Iss 8, p e927 (2023)
Epigenetic regulation occurs on the level of compacting DNA into chromatin. The functional unit of chromatin is the nucleosome, which consists of DNA wrapped around a core of histone proteins. While canonical histone proteins are incorporated into ch
Externí odkaz:
https://doaj.org/article/8649de83bb0147c9a868707b99e5b192
Autor:
Nora Bengoa-Vergniory, Emilie Faggiani, Paula Ramos-Gonzalez, Ecem Kirkiz, Natalie Connor-Robson, Liam V. Brown, Ibrar Siddique, Zizheng Li, Siv Vingill, Milena Cioroch, Fabio Cavaliere, Sarah Threlfell, Bradley Roberts, Thomas Schrader, Frank-Gerrit Klärner, Stephanie Cragg, Benjamin Dehay, Gal Bitan, Carlos Matute, Erwan Bezard, Richard Wade-Martins
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
CLR01 is a molecular tweezer that inhibits protein aggregation. Here the authors show that CLR01 protects dopaminergic neurons in vitro and in vivo in human neurons and in mouse models showing potential as a disease-modifying therapy for Parkinson’
Externí odkaz:
https://doaj.org/article/dbb405cbb99f4bdb826102e5b534b7da
Autor:
Gabriele Corda, Helle Bogtofte, Saba Saqlain, Brent J. Ryan, Milena Cioroch, Richard Wade-Martins, Ecem Kirkiz, Nora Bengoa-Vergniory, Maximilian Sloan, Rosalind F. Roberts, Matthew Williamson, Marta Cherubini, Josse Poppinga, Svenja Hester
Publikováno v:
The Journal of Neuroscience. 41:3731-3746
Alpha-synuclein pathology is associated with dopaminergic neuronal loss in the substantia nigra (SN) of Parkinson's patients. Working across human and mouse models, we investigated mechanisms by which the accumulation of soluble α-synuclein oligomer