Chronic rosiglitazone therapy normalizes expression of ACE1, SCD1 and other genes in the kidney of obese Zucker rats as determined by microarray analysis

Autor: Habtom W. Ressom, Liu H, Ecelbarger Cm, Tiwari S, Song J

Publikováno v: Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 116(6)

Thiazolidinediones increase tissue insulin sensitivity and are protective against worsening of nephropathy and hypertension in diabetes. Mechanisms underlying protection at the renal level likely involve a variety of unknown changes in gene expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c972fe128fa4854793dade799df08b6a
https://pubmed.ncbi.nlm.nih.gov/18700276

Nascent shifts in renal cellular metabolism, structure, and function due to chronic empagliflozin in prediabetic mice.

Autor: Shepard BD; Department of Human Science, Georgetown University, Washington, District of Columbia, United States., Chau J; Department of Medicine,Georgetown University, Washington, District of Columbia, United States., Kurtz R; Department of Human Science, Georgetown University, Washington, District of Columbia, United States., Rosenberg AZ; Department of Pathology, Johns Hopkins University, Baltimore, Maryland, United States., Sarder P; J Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, Florida, United States., Border SP; J Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, Florida, United States., Ginley B; Department of Pathology, Johns Hopkins University, Baltimore, Maryland, United States.; Department of Computational Cell Biology, Anatomy, and Pathology, State University of New York at Buffalo, Buffalo, New York, United States., Rodriguez O; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, United States.; Center for Translational Imaging, Georgetown University, Washington, District of Columbia, United States., Albanese C; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, United States.; Center for Translational Imaging, Georgetown University, Washington, District of Columbia, United States.; Department of Radiology, Georgetown University, Washington, District of Columbia, United States., Knoer G; Center for Translational Imaging, Georgetown University, Washington, District of Columbia, United States., Greene A; Department of Medicine,Georgetown University, Washington, District of Columbia, United States., De Souza AMA; Department of Medicine,Georgetown University, Washington, District of Columbia, United States., Ranjit S; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, District of Columbia, United States.; Microscopy & Imaging Shared Resources, Georgetown University, Washington, District of Columbia, United States., Levi M; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, District of Columbia, United States., Ecelbarger CM; Department of Medicine,Georgetown University, Washington, District of Columbia, United States.

Publikováno v: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2024 Apr 01; Vol. 326 (4), pp. C1272-C1290. Date of Electronic Publication: 2024 Mar 04.

Editorial: Insights in renal and epithelial physiology: 2021.

Autor: Ecelbarger CM; Department of Medicine/Division of Endocrinology and Metabolism, Georgetown University, Washington, DC, United States.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Lan HY; Department of Medicine/Division of Endocrinology and Metabolism, Georgetown University, Washington, DC, United States.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.

Publikováno v: Frontiers in physiology [Front Physiol] 2022 Aug 29; Vol. 13, pp. 998358. Date of Electronic Publication: 2022 Aug 29 (Print Publication: 2022).

Empagliflozin Treatment Attenuates Hepatic Steatosis by Promoting White Adipose Expansion in Obese TallyHo Mice.

Autor: Kurtz R; Department of Human Science, Georgetown University Medical Center, Washington, DC 20057, USA., Libby A; Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80012, USA., Jones BA; Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057, USA., Myakala K; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USA., Wang X; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USA., Lee Y; Department Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.; Center for Translational Imaging, Georgetown University Medical Center, Washington, DC 20057, USA., Knoer G; Department Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA., Lo Cascio JN; Department of Human Science, Georgetown University Medical Center, Washington, DC 20057, USA., McCormack M; Department Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA., Nguyen G; Department of Human Science, Georgetown University Medical Center, Washington, DC 20057, USA., Choos END; Department of Human Science, Georgetown University Medical Center, Washington, DC 20057, USA., Rodriguez O; Department Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.; Center for Translational Imaging, Georgetown University Medical Center, Washington, DC 20057, USA., Rosenberg AZ; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Ranjit S; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USA.; Microscopy & Imaging Shared Resources, Georgetown University Medical Center, Washington, DC 20057, USA., Albanese C; Department Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.; Center for Translational Imaging, Georgetown University Medical Center, Washington, DC 20057, USA.; Department of Radiology, Georgetown University Medical Center, Washington, DC 20057, USA., Levi M; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USA., Ecelbarger CM; Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA., Shepard BD; Department of Human Science, Georgetown University Medical Center, Washington, DC 20057, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 May 18; Vol. 23 (10). Date of Electronic Publication: 2022 May 18.

Selective Deletion of the Mechanistic Target of Rapamycin From the Renal Collecting Duct Principal Cell in Mice Down-Regulates the Epithelial Sodium Channel.

Autor: Chen B; Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, DC, United States., Fluitt MB; Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, DC, United States.; Department of Medicine, Howard University, Washington, DC, United States., Brown AL; Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, DC, United States., Scott S; Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, DC, United States., Gadicherla A; Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, DC, United States., Ecelbarger CM; Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, DC, United States.

Publikováno v: Frontiers in physiology [Front Physiol] 2022 Jan 04; Vol. 12, pp. 787521. Date of Electronic Publication: 2022 Jan 04 (Print Publication: 2021).