Tip 2 Diabetes Mellitus’lu Hastalarda Oksidatif ve Metabolik Parametrelerin HemoglobinA1c ile İlişkisi

Autor: Aysen Kutan Fenercioglu, Tayyibe Saler, Ece Genc, Yüksel Altuntaş

Publikováno v: Ankara Medical Journal, Vol 19, Iss 4, Pp 722-728 (2019)

Amaç: Bugüne kadar yapılan çalışmalar, tip 2 diabetes mellitus (DM)’lu hastalarda artmış oksidatif stres ve bozulmuş antioksidan savunma sisteminin diyabete bağlı komplikasyonların başlaması ve ilerlemesinde rol oynadığını ortaya

Externí odkaz: https://doaj.org/article/ba956c03ccb24919a1ce9096efac91ef

Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals

Autor: Rajagopal Krishnamoorthy, Yusuke Nakamura, Alice Giontella, Elisa Danese, Munir Pirmohamed, Hoi Y. Tong, Angela Tagetti, Marie-Anne Loriot, Pietro Minuz, Anke H. Maitland-van der Zee, Sheng-Lan Tan, Jim K Burmester, Richard B. Kim, Jamila Alessandra Perini, Ming Ta Michael Lee, Nita A. Limdi, Min Huang, Mohamed H. Shahin, Guilherme Suarez-Kurtz, Vanessa Roldán, Carlos Isaza, Hersh Sagreiya, Hye Sun Gwak, Vijay Kumar Kutala, Han-Jing Cen, Russ B. Altman, Antonio J. Carcas, Kunihiko Itoh, Vaiva Lesauskaite, Richard L. Berg, Cristina Mazzaccara, Kyung Eun Lee, Mariana R. Botton, Jieying Eunice Zhang, Anthonius de Boer, Yumao Zhang, Inna Y. Gong, Marianne K. Kringen, Paola Borgiani, Taimour Y. Langaee, Monica Taljaard, Vacis Tatarunas, Panos Deloukas, Chrisly Dillon, Alberto M. Borobia, Michael D. Caldwell, Katarzyna Drozda, Larisa H. Cavallari, Julie A. Johnson, Stephane Bourgeois, Lucia Sacchetti, Saurabh Singh Rathore, Stuart A. Scott, Martina Montagnana, Li-Zi Zhao, Charles A. Rivers, Mahmut Ozer, Taisei Mushiroda, Cristina Lucía Dávila-Fajardo, Andras Paldi, Marisa Cañadas-Garre, Rocío González-Conejero, Talitha I. Verhoef, Sherief Khalifa, Ivet Suriapranata, Carlo Federico Zambon, Balraj Mittal, Sara Raimondi, Ece Genc, Virginie Siguret, Andrea H. Ramirez, Cinzia Ciccacci, Keita Hirai, Enrique Jiménez-Varo, Hong-Hao Zhou, Anil Pathare, Steven A. Lubitz, Josh C. Denny, Aditi Shendre, Leonardo Beltrán, Kari Bente Foss Haug, Cristiano Fava, Vittorio Pengo

Publikováno v: Clin Pharmacol Ther
Clinical Pharmacology and Therapeutics, 105(6), 1477. Nature Publishing Group
Danese, E, Sara, R, Montagnana, M, Tagetti, A, Langaee, T, Borgiani, P, Ciccacci, C, Carcas, A J, Borobia, A M, Tong, H Y, Davila Fajardo, C, Rodrigues Botton, M, Bourgeois, S, Deloukas, P, Caldwell, M D, Burmester, J K, Berg, R L, Cavallari, L H, Drozda, K, Huang, M, Zhao, L-Z, Cen, H-J, Gonzalez-Conejero, R, Roldan, V, Nakamura, Y, Mushiroda, T, Gong, I Y, Kim, R B, Hirai, K, Itoh, K, Isaza, C, Beltran, L, Jimenez-Varo, E, Cañadas-Garre, M, Giontella, A, Kristiansen Kringen, M, Bente Foss Haug, K, Gwak, H S, Lee, K E, Minuz, P, Lee, M T M, Lubitz, S A, Scott, S, Mazzaccara, C, Sacchetti, L, Genç, E, Özer, M, Pathare, A, Krishnamoorthy, R, Paldi, A, Siguret, V, Loriot, M-A, Kumar Kutala, V, Suarez-Kurtz, G, Perini, J, Denny, J C, Ramirez, A H, Mittal, B, Singh Rathore, S, Sagreiya, H, Altman, R, Shahin, M H A, Khalifa, S I, Lindi, N A, Rivers, C, Shendre, A, Dillon, C, Suriapranata, I M, Zhou, H-H, Tan, S-L, Tatarunas, V, Lesauskaite, V, Zhang, Y, Maitland-van der Zee, A H, Verhoef, T I, de Boer, A, Taljaard, M, Zambon, C F, Pengo, V, zhang, J E, Pirmohamed, M, Johnson, J A & Fava, C 2018, ' The effect of CYP4F2, VKORC1 and CYP2C9 in influencing coumarin dose. A single patient data meta-analysis in more than 15,000 individuals ', Clinical Pharmacology and Therapeutics . https://doi.org/10.1002/cpt.1323
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics, 2019, 105 (6), pp.1477-1491. ⟨10.1002/cpt.1323⟩
Clinical pharmacology and therapeutics, 105(6), 1477-1491. Wiley-Blackwell
Clinical pharmacology and therapeutics
Paediatrics Publications

The CYP4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at individual patients' level to capture the possible effect of ethnicity, gene-gene interaction or other drugs on the association

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f48f76671021f7043e3ac2ca8c9e251
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061927761&origin=inward

HMGCR and ApoE mutations may cause different responses to lipid lowering statin therapy

Autor: Elif Çiğdem Altunok, E Bayam, Deniz Kirac, S Pala, Hazal Gezmiş, M. Dagdelen, Sabit Sarikaya, Ece Genc

Publikováno v: Cellular and Molecular Biology. 63:43-48

Coronary artery disease (CAD) and its complications are the major causes of death in the world. Although statins have been used to lower lipid levels in CAD patients, this goal can not be attained in 1/3 of the patients. The objective of this study w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff4c1052e181fe30fdeab6bbfb54e7e
https://doi.org/10.14715/cmb/2017.63.10.6

An expert system to predict warfarin dosage in Turkish patients depending on genetic and non-genetic factors

Autor: Mahmut Ozer, Ece Genc, Osman Altay, Mustafa Ulas

Publikováno v: ISDFS

Warfarin which is a Vitamin K antagonist is one of the most widely used oral anticoagulants worldwide. Genetic factors affecting warfarin (CYP2C9, CYP4F2 and VKORC1) have been shown in different studies. Apart from genetic factors, the effects of age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c7700c542aeb2753b1c143c44890e6
https://hdl.handle.net/20.500.11831/7053

A system biology approach for modeling the brain: from genes to consciousness

Autor: Ece Genc

Publikováno v: Journal of Neurology and Neuroscience.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44b4ac22c64e4b4e4a9ba6ff1f40d7e3
https://doi.org/10.21767/2171-6625-c1-007