Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Eccojc/1000"'
1
Therapeutic Potential of a Self-Assembling Peptide Hydrogel to Treat Colonic Injuries Associated with Inflammatory Bowel Disease
Autor: Jun Akiba, Tetsuhiro Yoshimura, Tatsuyuki Kakuma, Kotaro Kuwaki, Atsushi Mori, Shuhei Fukunaga, Takuji Torimura, Keiichi Mitsuyama, Masaru Morita, Hidetoshi Takedatsu, Hiroshi Yamasaki, Toshihiro Araki, Shinichiro Yoshioka, Kozo Tsuruta
Publikováno v: Journal of Crohn's & Colitis
Background and Aims The Self-assembling Peptide Hydrogel [SAPH, PuraMatrix], a fully synthetic peptide solution designed to replace collagen, has recently been used to promote mucosal regeneration in iatrogenic ulcers following endoscopic submucosal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812c5fdea4ee1f71611472c5ac1596f5
https://doi.org/10.1093/ecco-jcc/jjab033
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2
Mycobacterium Avium Subspecies Paratuberculosis Infection and Biological Treatment of IBD
Autor: E Proietti, Maikel P. Peppelenbosch, Gwenny M. Fuhler
Publikováno v: Journal of Crohn's & colitis, 15(8), 1247-1249. Oxford University Press
Journal of Crohn's & Colitis
Background The role of Mycobacterium avium paratuberculosis [MAP] in inflammatory bowel disease [IBD], especially Crohn’s disease [CD] is controversial due conflicting results and lack of reproducibility and standardised tests. The current study fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6c755da10dafd70b87ebff8dc7a074
https://doi.org/10.1093/ecco-jcc/jjab027
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3
Dysregulation of Metabolic Pathways in Circulating Natural Killer Cells Isolated from Inflammatory Bowel Disease Patients
Autor: Glen A. Doherty, Miriam Tosetto, Vanessa Zaiatz Bittencourt, Elizabeth J. Ryan, Fiona Jones
Publikováno v: Journal of Crohn's & Colitis
Background and Aims Inflammatory bowel diseases [IBD], comprising Crohn’s disease [CD] and ulcerative colitis [UC], are chronic conditions characterized by severe dysregulation of innate and adaptive immunity resulting in the destruction of the int
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6033dd159a82b3d4ac60dd7ec08878
http://europepmc.org/articles/PMC8328302
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5
The Impact of NOD2 Genetic Variants on the Gut Mycobiota in Crohn’s Disease Patients in Remission and in Individuals Without Gastrointestinal Inflammation
Autor: Darren Smith, Charlie W. Lees, Nicholas A. Kennedy, Georgina L. Hold, Miles Parkes, Simon H. Bridge, Andrew Nelson, John K Lodge, Chris Probert, Christopher J. Stewart, John C. Mansfield, Christopher A. Lamb, Mark Tremelling
Publikováno v: Journal of Crohn's & Colitis
JOURNAL OF CROHNS & COLITIS
Background and Aims Historical and emerging data implicate fungi in Crohn’s disease [CD] pathogenesis. However, a causal link between mycobiota, dysregulated immunity, and any impact of NOD2 variants remains elusive. This study aims to evaluate ass
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531334b0a652f4a0961eeb0280460134
https://doi.org/10.1093/ecco-jcc/jjaa220
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6
Tyrosine Kinase 2 Signalling Drives Pathogenic T cells in Colitis
Autor: Mohammed Ghiboub, Caroline Verseijden, Wouter J. de Jonge, Patricia van Hamersveld, Mathias Müller, Pim J. Koelink, Rab K. Prinjha, Matthew J Bell, Olaf Welting, Leonie C. De Vries, Geert R. D'Haens, Manon E. Wildenberg, Inmaculada Rioja, Birgit Strobl
Publikováno v: Journal of Crohn's & Colitis
Journal of Crohn's & colitis, 15(4), 617-630. Elsevier
Background and Aims Tyrosine kinase 2 [TYK2] is required for the signalling of key cytokines in the pathogenesis of inflammatory bowel disease [IBD]. We assessed the efficacy of a novel selective TYK2 inhibitor [TYK2i] in experimental colitis, using
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7452d415a8b696ebbe9867210e2281ce
http://europepmc.org/articles/PMC8023831
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7
Early Postoperative Endoscopic Recurrence in Crohn’s Disease Is Characterised by Distinct Microbiota Recolonisation
Autor: André D'Hoore, Kathleen Machiels, Albert Wolthuis, João Sabino, Zixuan Xie, Severine Vermeire, Alba Santiago, Gert De Hertogh, Marc Ferrante, Chaysavanh Manichanh, Marta Pozuelo del Río, Victòria Pascal Andreu, Adrian Martinez-De la Torre, David Campos
Publikováno v: Journal of Crohn's & Colitis
Background and Aims Intestinal microbiota dysbiosis is implicated in Crohn’s disease [CD] and may play an important role in triggering postoperative disease recurrence [POR]. We prospectively studied faecal and mucosal microbial recolonisation foll
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b7dafea8b4c7d90b1ad45590d3d678
https://doi.org/10.1093/ecco-jcc/jjaa081
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8
Cell Therapy With Mesenchymal Stem Cells Induces an Innate Immune Memory Response That Attenuates Experimental Colitis in the Long Term
Autor: Rosario Hervas-Salcedo, Juan A. Bueren, María Fernández-García, Marina I. Garin, Mercedes Lopez-Santalla
Publikováno v: Journal of Crohn's & Colitis
Background and Aims Mesenchymal stem cells [MSCs] are used in preclinical and clinical studies for treatment of immune-mediated disorders, thanks to their immunomodulatory properties. Cell therapy with MSCs induces multiple effects in the immune syst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572565874fc6bcc6da7bc068030515f2
https://doi.org/10.1093/ecco-jcc/jjaa079
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9
Development of Gut-Selective Pan-Janus Kinase Inhibitor TD-1473 for Ulcerative Colitis: A Translational Medicine Programme
Autor: Raj Bhandari, M. Teresa Pulido-Rios, David T Beattie, Reuben Sana, Brihad Abhyankar, Jonathan A. Leighton, Jacky Woo, Richard Graham, Eva Situ, Ravi Ganeshappa, Erik Sandvik, Melanie A. Kleinschek, Whitney Krey, David L. Boyle, Deanna D Nguyen, Julián Panés, William J. Sandborn, Patrick Brassil
Publikováno v: Journal of Crohn's & Colitis
Journal of Crohn's & colitis, vol 14, iss 9
Background and Aims Oral systemic pan-Janus kinase [JAK] inhibition is effective for ulcerative colitis [UC] but is limited by toxicities. We describe preclinical to clinical translation of TD-1473—an oral gut-selective pan-JAK inhibitor—from in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5f63ccc3b54b28cf78acb55ba9f1eb
https://doi.org/10.1093/ecco-jcc/jjaa049
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10
Anaplastic Large Cell T Cell Lymphoma in a Patient With Severe Therapy-refractory Crohn's Disease on Long-standing Immunosuppressive Medication During Ustekinumab Treatment
Autor: Razvan L. Miclea, Fabienne G M Smeets, Marieke Pierik, Marjolein van der Poel, Paulien R Liedorp, Ad A.M. Masclee
Publikováno v: Journal of Crohn's & Colitis
Use of ustekinumab in Crohn’s disease was approved in 2016, and consequently data regarding its real-world safety are still limited. We here present a 29-year-old woman with severe therapy-refractory Crohn’s disease, who developed an anaplastic l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15179723402bf8e171572124d47fbb50
https://doi.org/10.1093/ecco-jcc/jjz084
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