Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ecadotril"'
Publikováno v:
JACC: Heart Failure. 2:663-670
Neprilysin is an enzyme that contributes to the breakdown of the biologically active natriuretic peptides and several other vasoactive compounds. Inhibiting neprilysin has been a therapeutic target for several compounds that have been tested in cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d0edfcbfc52e4ca26f5a2e25c2611a
https://doi.org/10.1016/j.jchf.2014.09.001
https://doi.org/10.1016/j.jchf.2014.09.001
Autor:
K. A Jayashree
Publikováno v:
Research Journal of Pharmacy and Technology. 11:2111
Cardiovascular diseases (CVD) continue to represent the major cause of death, morbidity and healthcare expenditure worldwide. Hypertension and heart failure, the most important cardiovascular disease entities, are associated with imbalance in neuroho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7311fb4beb8d6cc0fd10a4e6d703a4d
https://doi.org/10.5958/0974-360x.2018.00391.8
https://doi.org/10.5958/0974-360x.2018.00391.8
Autor:
Takayuki Mishima, Victor G. Sharov, George Suzuki, Sidney Goldstein, Anastassia Todor, Mitsuhiro Tanimura, Elaine J. Tanhehco, Hani N. Sabbah
Publikováno v:
Cardiovascular Drugs and Therapy. 16:209-214
Background. The diuretic actions of endogenously produced atrial natriuretic factor (ANF) may be beneficial in the treatment of chronic heart failure (CHF). Neutral endopeptidase (NEP) is the primary enzyme responsible for the degradation of ANF. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9daf3f9c466d3181cadaeb61952c6dbf
https://doi.org/10.1023/a:1020644304771
https://doi.org/10.1023/a:1020644304771
Autor:
Basil S. Lewis, Nader Khader, K. Uziel, David A. Halon, Moshe Y. Flugelman, Amnon Merdler, Nomi Gordon, Basheer Karkabi, Rita Yuval
Publikováno v:
European Journal of Heart Failure. 3:217-223
Background: Clinical trials, the gold standard for the evaluation of new therapeutic strategies, may prove a drug to be beneficial, harmful or neutral according to its effect on the end-point(s) under study. Aims: To study the reaction and perspectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44423ebc480b8b61e2fc86ed35bd3945
https://doi.org/10.1016/s1388-9842(00)00151-3
https://doi.org/10.1016/s1388-9842(00)00151-3
Autor:
Jean-Christophe Plaquevent, Jeanne-Marie Lecomte, Pierre Duhamel, Denis Danvy, Lucette Duhamel, Jean-Charles Schwartz, Thierry Monteil, Claude Gros
Publikováno v:
Synthetic Communications. 31:211-218
We describe herein a method providing access to both enantiomers of 3-acetylthio-2-benzylpropionic acid via enzymatic desymmetrization of 2-benzyl-1,3-propanediol. These compounds are respectively the starting materials for the synthesis of ecadotril
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::262c61b737d7c25469e52dc8c609b839
https://doi.org/10.1081/scc-100000201
https://doi.org/10.1081/scc-100000201
Publikováno v:
Journal of Hypertension. 18:927-933
Objective Cyclosporine (CysA), a potent immunosuppressant, is associated with hypertension and nephrotoxicity. Neutral endopeptidase (NEP) degrades vasoactive peptides, including the natriuretic peptides and endothelin-1 (ET-1). We conducted the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6a8005f758730282cbe6627d3210ba
https://doi.org/10.1097/00004872-200018070-00015
https://doi.org/10.1097/00004872-200018070-00015
Publikováno v:
American Journal of Veterinary Research. 61:425-429
Objective—To determine the toxicity of ecadotril in dogs. Animals—74 healthy 4- to 11-month-old Beagles. Procedure—To determine acute toxicity, ecadotril (2,000 mg/kg of body weight, PO) in a gelatin capsule was administered once to 2 dogs, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f186be4005d34400757f75258b220496
https://doi.org/10.2460/ajvr.2000.61.425
https://doi.org/10.2460/ajvr.2000.61.425
Publikováno v:
American Journal of Veterinary Research. 61:333-338
Objective—To evaluate short-term hemodynamic effects of ecadotril in a model of congestive heart failure in dogs. Animals—6 conscious adult male dogs. Procedures—Instruments were placed in dogs to measure left ventricular, aortic, and atrial bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a34b6338eab52dd842b2923f5b2255
https://doi.org/10.2460/ajvr.2000.61.333
https://doi.org/10.2460/ajvr.2000.61.333
Autor:
Uri Elkayam, Stuart D. Katz, Frank C. Messineo, Robert J. Cody, Sidney Goldstein, Christopher M. O'Connor, Edward K. Kasper, Barry M. Massie, James M. McKenney, Mihai Gheorghiade, Wendy A. Gattis, John C. Burnett, James R. Gilbert, Christopher B. Granger
Publikováno v:
American Heart Journal. 138:1140-1148
Objective To determine the short-term safety and tolerability of the addition of ecadotril to conventional therapy in patients with mild to moderate heart failure. Methods Fifty ambulatory patients, 18 to 75 years of age, with mild to moderate heart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7b194a09e0932c76190264b631d982e
https://doi.org/10.1016/s0002-8703(99)70081-5
https://doi.org/10.1016/s0002-8703(99)70081-5
Publikováno v:
Cardiovascular Research. 31:891-898
Objective: The aortovenocaval fistular (AVF) rat represents a model of heart failure caused by increased cardiac volume overload and reduced renal function. Both circulating vasoconstrictors like the renin-angiotensin-aldosterone system and vasodilat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47003dddcf8d90b4c1a41db448e911e8
https://doi.org/10.1016/s0008-6363(96)00062-4
https://doi.org/10.1016/s0008-6363(96)00062-4