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Akademický článek

A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens

Autor: Gemma L. Pearson, Natalie Mellett, Kwan Yi Chu, Ebru Boslem, Peter J. Meikle, Trevor J. Biden

Publikováno v: Molecular Metabolism, Vol 5, Iss 6, Pp 404-414 (2016)

Objective: Glucose promotes lipid remodelling in pancreatic β-cells, and this is thought to contribute to the regulation of insulin secretion, but the metabolic pathways and potential signalling intermediates have not been fully elaborated. Methods:

Externí odkaz: https://doaj.org/article/e7690088ab7b4cae98abb75ccb8be222

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Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential

Publikováno v: Carlessi, R, Denisenko, E, Boslem, E, Köhn-Gaone, J, Main, N, Abu bakar, N D B, Shirolkar, G D, Jones, M, Beasley, A B, Poppe, D, Dwyer, B J, Jackaman, C, Tjiam, M C, Lister, R, Karin, M, Fallowfield, J A, Kendall, T J, Forbes, S J, Gray, E S, Olynyk, J K, Yeoh, G, Forrest, A R R, Ramm, G A, Febbraio, M A & Tirnitz-Parker, J E E 2023, ' Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential ', Cell Genomics, pp. 100301 . https://doi.org/10.1016/j.xgen.2023.100301

Current approaches to stage chronic liver diseases have limited utility to predict liver cancer risk. Here, we employed single nucleus RNA sequencing (snRNA-seq) to characterize the cellular microenvironment of healthy and pre-malignant livers using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79b1e0fbed62d67780b4f1bbfca2265
https://doi.org/10.1016/j.xgen.2023.100301

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Single Nucleus RNA Sequencing of Pre-Malignant Liver Reveals Disease-Associated Hepatocyte State with HCC Prognostic Potential

SUMMARYCurrent approaches to stage chronic liver diseases have limited utility to directly predict liver cancer risk. Here, we employed single nucleus RNA sequencing (snRNA-seq) to characterize the cellular microenvironment of healthy and chronically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f6343e879a53fd2c88b13154acb2379
https://doi.org/10.1101/2022.03.25.485695

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Therapeutic Blockade of ER Stress and Inflammation Prevents High Fat Diet-Induced NASH and Progression to Hepatocellular Carcinoma

Autor: Ebru Boslem, Saskia Riebe, Benoit Smeuninx, Casey L. Egan, Surafel Tegegne, Emma McLennan, Max Nobis, Andre Mu, Cameron J. Nowell, Neil Horadagoda, Natalie A. Mellet, Rodrigo Carlessi, Paul Timpson, Janina EE Tirnitz-Parker, Peter J. Meikle, Stefan Rose-John, Michael Karin, Mark Anthony Febbraio

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef058022d54cea2d53a7256fa56cab83
https://doi.org/10.2139/ssrn.4001943

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Current and Future Treatments in the Fight against Non-Alcoholic Fatty Liver Disease

Autor: Ebru Boslem, Benoit Smeuninx, Mark A. Febbraio

Publikováno v: Cancers
Cancers, Vol 12, Iss 1714, p 1714 (2020)

Obesity is recognised as a risk factor for many types of cancers, in particular hepatocellular carcinoma (HCC). A critical factor in the development of HCC from non-alcoholic fatty liver disease (NAFLD) is the presence of non-alcoholic steatohepatiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7618ae796f05e0cec36e3c6ffedbb7
https://doi.org/10.3390/cancers12071714

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Cyto-Immuno-Therapy for Cancer: A Pathway Elicited by Tumor-Targeted, Cytotoxic Drug-Packaged Bacterially Derived Nanocells

Autor: John A. Boockvar, Ebru Boslem, Natasha Vanegas, Gemma E. Stubbs, Katarzyna Smolarczyk, Stephen Clarke, Jennifer A. MacDiarmid, Eva St. Clair, Sharon M. Sagnella, Lu Yang, Himanshu Brahmbhatt, Stacey L. Pattison, Estefania Martino-Echarri

Publikováno v: Cancer cell. 37(3)

Summary Immunotherapy has emerged as a powerful new chapter in the fight against cancer. However, it has yet to reach its full potential due in part to the complexity of the cancer immune response. We demonstrate that tumor-targeting EDV nanocells fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b76974c9a1270c0be273bfe2cb8229
https://pubmed.ncbi.nlm.nih.gov/32183951

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Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

Autor: P. Tess Whitworth, Laurène Vetterli, Kyle L. Hoehn, Le May Thai, Aimee Davenport, James Cantley, Natalie A. Mellett, Ebru Boslem, Peter J. Meikle, David E. James, Nandor J. Nemes, Trevor J. Biden

Publikováno v: Diabetologia

Aims/hypothesis Pancreatic beta cells secrete insulin to maintain glucose homeostasis, and beta cell failure is a hallmark of type 2 diabetes. Glucose triggers insulin secretion in beta cells via oxidative mitochondrial pathways. However, it also fee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c471bb8af08e94f78d0f5dfd10f4de66
https://pubmed.ncbi.nlm.nih.gov/30334081

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Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

Autor: Ebru Boslem, Nancy Sue, Kwan Yi Chu, Trevor J. Biden

Publikováno v: Trends in Endocrinology & Metabolism. 25:389-398

Failure of the unfolded protein response (UPR) to maintain optimal folding of pro-insulin in the endoplasmic reticulum (ER) leads to unresolved ER stress and β cell death. This contributes not only to some rare forms of diabetes, but also to type 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a85e3caf0122b76e8b27bce27ceed4
https://doi.org/10.1016/j.tem.2014.02.003

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