Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants.

Autor: Beth Holder, David J C Miles, Steve Kaye, Sarah Crozier, Nuredin Ibrahim Mohammed, Nancy O Duah, Elishia Roberts, Olubukola Ojuola, Melba S Palmero, Ebrima S Touray, Pauline Waight, Matthew Cotten, Sarah Rowland-Jones, Marianne van der Sande, Hilton Whittle

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e14013 (2010)

BACKGROUND:Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are persistent herpesviruses that have various immunomodulatory effects on their hosts. Both viruses are usually acquired in infancy in Sub-Saharan Africa, a region where childhood vaccine

Externí odkaz: https://doaj.org/article/0e3c5922156b48968c9356a73f79aba5

Enhancement of cytokine‐driven NK cell IFN‐γ production after vaccination of HCMV infected Africans

Autor: Martin R. Goodier, Ed Clarke, Alansana Darboe, Ebrima Danso, Rita Wegmüller, Ebrima S. Touray, Ama Umesi, Eleanor M. Riley, Sophie E. Moore

Publikováno v: European Journal of Immunology
Darboe, A, Danso, E, Clarke, E, Umesi, A, Touray, E, Wegmuller, R, Moore, S E, Riley, E M & Goodier, M R 2017, ' Enhancement of cytokine-driven NK cell IFN-γ production after vaccination of HCMV infected Africans ', European Journal of Immunology, vol. 47, no. 6, pp. 1040-1050 . https://doi.org/10.1002/eji.201746974

Human cytomegalovirus (HCMV) infection drives the phenotypic and functional differentiation of NK cells, thereby influencing the responses of these cells after vaccination. NK cell functional differentiation is particularly advanced in African popula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a6084cd8c8517e6842d78b6177e6be
http://europepmc.org/articles/PMC5888140

Cytomegalovirus infection induces T-cell differentiation without impairing antigen-specific responses in Gambian infants

Autor: Melba S. Palmero, Samuel Nyamweya, Syed M. A. Zaman, Sarah Rowland-Jones, Ebrima S. Touray, Beth Holder, David Miles, Mariama Sanneh, Marianne A B van der Sande, Hilton Whittle, Sarah Crozier

Cytomegalovirus (CMV) infection induces profound differentiation of T cells, and is associated with impaired responses to other immune challenges. We therefore considered whether CMV infection and the consequent T-cell differentiation in Gambian infa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7944db0d9d31f7bb4019bcb2931b406
https://doi.org/10.1111/j.1365-2567.2007.02787.x

Effects of Antenatal and Postnatal Environments on CD4 T-Cell Responses toMycobacterium bovisBCG in Healthy Infants in The Gambia

Autor: Martin O. C. Ota, Sarah Rowland-Jones, Olubukola Ojuola, Arnaud Marchant, Melba S. Palmero, Mariama Sanneh, Ebrima S. Touray, Hilton Whittle, Sarah Crozier, Marianne A B van der Sande, David Miles

Publikováno v: Clinical and Vaccine Immunology. 15:995-1002

TheMycobacterium bovisBCG vaccine has a poor record of efficacy in low-income tropical settings. Against this background, we evaluated the immune response of infants to mycobacterial antigens over the 2 years following BCG vaccination at birth by mea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22928d0bda663af82a298e2b41a0eb45
https://doi.org/10.1128/cvi.00037-08

Placental malaria is associated with attenuated CD4 T-cell responses to tuberculin PPD 12 months after BCG vaccination

Autor: Melba S. Palmero, Katie L. Flanagan, Olubukola Ojuola, Pauline Waight, Marianne A B van der Sande, Ebrima S. Touray, David Miles, Hilton Whittle, Sarah Crozier, Brigitte Walther

Publikováno v: BMC Infectious Diseases, Vol 12, Iss 1, p 6 (2012)
BMC Infectious Diseases

Background Placental malaria (PM) is associated with prenatal malaise, but many PM+ infants are born without symptoms. As malaria has powerful immunomodulatory effects, we tested the hypothesis that PM predicts reduced T-cell responses to vaccine cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75eea4f2a49ad367537dfb7eeb456185
http://www.biomedcentral.com/1471-2334/12/6