A Versatile Virus-Mimetic Engineering Approach for Concurrent Protein Nanocage Surface-Functionalization and Cargo Encapsulation.

Autor: Sheng Y; Faculty of Life Sciences and Medicine, Institute of Pharmaceutical Science, King's College London, London, SE1 9NH, UK., Chen Z; Faculty of Life Sciences and Medicine, Institute of Pharmaceutical Science, King's College London, London, SE1 9NH, UK., Cherrier MV; Univ. Grenoble Alpes, CEA, CNRS, IBS, Metalloproteins Unit, Grenoble, CS 10090, France., Martin L; Univ. Grenoble Alpes, CEA, CNRS, IBS, Metalloproteins Unit, Grenoble, CS 10090, France., Bui TTT; Randall Centre for Cell & Molecular Biophysics, King's College London, London, SE11UL, UK., Li W; Faculty of Life Sciences and Medicine, Institute of Pharmaceutical Science, King's College London, London, SE1 9NH, UK., Lynham S; Proteomics Core Facility, James Black Centre, King's College London, London, SE5 9NU, UK., Nicolet Y; Univ. Grenoble Alpes, CEA, CNRS, IBS, Metalloproteins Unit, Grenoble, CS 10090, France., Ebrahimi KH; Faculty of Life Sciences and Medicine, Institute of Pharmaceutical Science, King's College London, London, SE1 9NH, UK.

Publikováno v: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Aug; Vol. 20 (31), pp. e2310913. Date of Electronic Publication: 2024 May 10.

Ancient complexes of iron and sulfur modulate oncogenes and oncometabolism.

Autor: Nghi HT; Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Sciences, King's College London, London, United Kingdom., Shahmohammadi S; Institute of Pharmaceutical Chemistry, Interdisciplinary Excellence Center and Stereochemistry Research Group, Eötvös Loránd Research Network, Faculty of Pharmacy, University of Szeged, H-6720, Szeged, Hungary., Ebrahimi KH; Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Sciences, King's College London, London, United Kingdom. Electronic address: Kourosh.ebrahimi@kcl.ac.uk.

Publikováno v: Current opinion in chemical biology [Curr Opin Chem Biol] 2023 Oct; Vol. 76, pp. 102338. Date of Electronic Publication: 2023 Jun 07.

VITAS, a sensitive in vivo selection assay to discover enzymes producing antiviral natural products.

Autor: Alharbi AF; Institute of Pharmaceutical Science, King's College London, London, UK. Kourosh.ebrahimi@kcl.ac.uk., Kim H; Institute of Pharmaceutical Science, King's College London, London, UK. Kourosh.ebrahimi@kcl.ac.uk., Chumroo D; Institute of Pharmaceutical Science, King's College London, London, UK. Kourosh.ebrahimi@kcl.ac.uk., Ji Y; Institute of Pharmaceutical Science, King's College London, London, UK. Kourosh.ebrahimi@kcl.ac.uk., Hakil M; Institute of Pharmaceutical Science, King's College London, London, UK. Kourosh.ebrahimi@kcl.ac.uk., Ebrahimi KH; Institute of Pharmaceutical Science, King's College London, London, UK. Kourosh.ebrahimi@kcl.ac.uk.

Publikováno v: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 May 02; Vol. 59 (36), pp. 5419-5422. Date of Electronic Publication: 2023 May 02.

Radical-SAM dependent nucleotide dehydratase (SAND), rectification of the names of an ancient iron-sulfur enzyme using NC-IUBMB recommendations.

Autor: Ji Y; Institute of Pharmaceutical Science, King's College London, London, United Kingdom., Wei L; Institute of Pharmaceutical Science, King's College London, London, United Kingdom., Da A; Institute of Pharmaceutical Science, King's College London, London, United Kingdom., Stark H; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Düsseldorf, Duesseldorf, Germany., Hagedoorn PL; Department of Biotechnology, Delft University of Technology, Delft, Netherlands., Ciofi-Baffoni S; Magnetic Resonance Center (CERM), University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di Metalloproteine (CIRMMP), Florence, and Department of Chemistry, University of Florence, Florence, Italy., Cowley SA; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom., Louro RO; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República-EAN, Oeiras, Portugal., Todorovic S; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República-EAN, Oeiras, Portugal., Mroginski MA; Institute of Chemistry, Technische Universität Berlin, Berlin, Germany., Nicolet Y; Université Grenoble Alpes, Grenoble, France., Roessler MM; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, United Kingdom., Le Brun NE; Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich, United Kingdom., Piccioli M; Magnetic Resonance Center (CERM), University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di Metalloproteine (CIRMMP), Florence, and Department of Chemistry, University of Florence, Florence, Italy., James WS; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom., Hagen WR; Department of Biotechnology, Delft University of Technology, Delft, Netherlands., Ebrahimi KH; Institute of Pharmaceutical Science, King's College London, London, United Kingdom.

Publikováno v: Frontiers in molecular biosciences [Front Mol Biosci] 2022 Oct 21; Vol. 9, pp. 1032220. Date of Electronic Publication: 2022 Oct 21 (Print Publication: 2022).

Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics.

Autor: Quinn TM; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh., Gaughan EE; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh., Bruce A; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Antonelli J; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., O'Connor R; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Li F; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., McNamara S; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Koch O; Regional Infectious Disease Unit, NHS Lothian, UK., MacKintosh C; Regional Infectious Disease Unit, NHS Lothian, UK., Dockrell D; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Regional Infectious Disease Unit, NHS Lothian, UK., Walsh T; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh., Blyth KG; Institute of Cancer Sciences, University of Glasgow, UK., Church C; Department of Respiratory Medicine, Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde Health Board, Glasgow, UK., Schwarze J; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Boz C; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Valanciute A; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Burgess M; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Emanuel P; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Mills B; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Rinaldi G; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Hardisty G; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Mills R; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Findlay EG; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Jabbal S; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh., Duncan A; Regional Infectious Disease Unit, NHS Lothian, UK., Plant S; Regional Infectious Disease Unit, NHS Lothian, UK., Marshall ADL; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh., Young I; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Russell K; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Scholefield E; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Nimmo AF; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh., Nazarov IB; Latus Therapeutics, Oxford, UK; Department of Pharmacology, University of Oxford, Oxford, UK., Churchill GC; Department of Pharmacology, University of Oxford, Oxford, UK., McCullagh JSO; Department of Chemistry, University of Oxford, Oxford, UK., Ebrahimi KH; Institute of Pharmaceutical Science, King's College London, UK., Ferrett C; Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Templeton K; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh., Rannard S; Centre of Excellence for Long-acting Therapeutics, Materials Innovation Factory and Department of Pharmacology and Therapeutics, University of Liverpool, UK., Owen A; Centre of Excellence for Long-acting Therapeutics, Materials Innovation Factory and Department of Pharmacology and Therapeutics, University of Liverpool, UK., Moore A; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Finlayson K; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Shankar-Hari M; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK., Norrie J; Centre for Cardiovascular Science, Queen's Medical Research Institute, Bioquarter, University of Edinburgh, Edinburgh, UK., Parker RA; Edinburgh Clinical Trials Unit (ECTU), Usher Institute, University of Edinburgh, Edinburgh, UK., Akram AR; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh., Anthony DC; Department of Pharmacology, University of Oxford, Oxford, UK., Dear JW; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh,; Centre for Cardiovascular Science, Queen's Medical Research Institute, Bioquarter, University of Edinburgh, Edinburgh, UK., Hirani N; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh., Dhaliwal K; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh,. Electronic address: Kev.Dhaliwal@ed.ac.uk.

Publikováno v: EBioMedicine [EBioMedicine] 2022 Feb; Vol. 76, pp. 103856. Date of Electronic Publication: 2022 Feb 11.