Single-mitochondrion sequencing uncovers distinct mutational patterns and heteroplasmy landscape in mouse astrocytes and neurons.

Autor: Kadam PS; Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Yang Z; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA., Lu Y; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., Zhu H; Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Atiyas Y; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA., Shah N; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA., Fisher S; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., Nordgren E; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., Kim J; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., Issadore D; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA. issadore@seas.upenn.edu., Eberwine J; Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. eberwine@pennmedicine.upenn.edu.

Publikováno v: BMC biology [BMC Biol] 2024 Jul 29; Vol. 22 (1), pp. 162. Date of Electronic Publication: 2024 Jul 29.

CHEX-seq detects single-cell genomic single-stranded DNA with catalytical potential.

Autor: Lu Y; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., Lee J; Department of Systems Pharmacology and Translational Therapeutics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Li J; Department of Systems Pharmacology and Translational Therapeutics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Allu SR; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Wang J; Department of Systems Pharmacology and Translational Therapeutics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Kim H; Department of Systems Pharmacology and Translational Therapeutics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Bullaughey KL; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., Fisher SA; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., Nordgren CE; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., Rosario JG; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., Anderson SA; Department of Psychiatry, Children's Hospital of Philadelphia, ARC 517, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA., Ulyanova AV; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Brem S; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Chen HI; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Wolf JA; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Grady MS; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Vinogradov SA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Kim J; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., Eberwine J; Department of Systems Pharmacology and Translational Therapeutics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. eberwine@pennmedicine.upenn.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Nov 14; Vol. 14 (1), pp. 7346. Date of Electronic Publication: 2023 Nov 14.

Elk-1 Associates with the Mitochondrial Permeability Transition Pore Complex in Neurons

Autor: Barrett, L. E., Van Bockstaele, E. J., Sul, J. Y., Takano, H., Haydon, P. G., Eberwine, J. H.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2006 Mar . 103(13), 5155-5160.

Externí odkaz: https://www.jstor.org/stable/30048761

Subcellular omics: a new frontier pushing the limits of resolution, complexity and throughput.

Autor: Eberwine J; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. eberwine@pennmedicine.upenn.edu., Kim J; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA. Junhyong@sas.upenn.edu., Anafi RC; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Brem S; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bucan M; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Fisher SA; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Grady MS; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Herr AE; Department of Bioengineering, University of California at Berkeley, Berkeley, CA, USA., Issadore D; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Jeong H; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.; Department of Chemical and Biomolecular Engineering, , University of Pennsylvania, Philadelphia, PA, USA., Kim H; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lee D; Department of Chemical and Biomolecular Engineering, , University of Pennsylvania, Philadelphia, PA, USA., Rubakhin S; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Sul JY; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sweedler JV; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Wolf JA; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zaret KS; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zou J; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.

Publikováno v: Nature methods [Nat Methods] 2023 Mar; Vol. 20 (3), pp. 331-335.

Expression profiling of small cellular samples in cancer: less is more.

Autor: Glanzer, J. G.¹, Eberwine, J. H.¹ eberwine@pharm.med.upenn.edu

Publikováno v: British Journal of Cancer. 3/22/2004, Vol. 90 Issue 6, p1111-1114. 4p.